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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Hibiscus rosa-sinensis is a tropical plant used in traditional medicine for its diverse pharmacological activities, including antidiabetic, antihypertensive, and antioxidant effects [PMID:37218183, 41323831].
Contexte
Hibiscus rosa-sinensis, commonly known as the shoe flower, is an ever-blossoming plant found in tropical and subtropical regions of Asia, Africa, and America [PMID:41323831, 37720793].
Usages traditionnels
It has been extensively used in conventional and folk medicine worldwide [PMID:37218183, 37720793], and is specifically used in Brazilian traditional medicine for the treatment of diabetes [PMID:28644857] and traditionally to treat hypertension [PMID:35352670].
Composés actifs
The plant contains flavonoids (including quercetin and kaempferol), anthocyanins (such as cyanidin-sophoroside), tannins, terpenoids, saponins, cyclopeptide alkaloids, vitamins, and phthalates [PMID:37218183, 41323831, 36838766, 37720793]. Roots specifically contain glycosides and phytosterols [PMID:37218183].
Mécanisme d'action
Bioactive compounds scavenge reactive oxygen and nitrogen species and modulate inflammatory markers (IL-6, TNF-α, PPAR-γ, cyclooxygenase) and oxidative markers (MDA, MPO, NO, SOD, GSH) [PMID:41323831]. Cardioprotective effects are linked to the regulation of PPAR-γ, SREBP-1c, acetyl-CoA carboxylase, and fatty acid synthase [PMID:41323831]. Antihypertensive activity is associated with Angiotensin-Converting Enzyme-2 (ACE-2) and Ca2+ channels pathways [PMID:35352670].
Preuves cliniques
Preuve DDiabetes/Dyslipidemia
Root extract (500 mg/kg) in diabetic rats significantly decreased blood glucose and plasma lipids and reactivated post heparin lipoprotein lipase activity [PMID:24381420].
Preuve DHypertension
Aqueous extract of flowers (100 mg/kg) in rats demonstrated antihypertensive and vasorelaxant activity [PMID:35352670].
Preuve DBacterial Infections
Chloroform and ethanol extracts showed potent inhibitory effects against Gram-positive and Gram-negative bacteria, including S. aureus and E. coli [PMID:40330800].
Preuve DFertility
Ethanolic root extract (400 mg/kg) showed 100% inhibition of implantation and uterotropic activity in rats [PMID:18317554].
Sécurité et effets indésirables
Hibiscus flowers are generally well tolerated, although allergic reactions are possible, including cross-reactions with other Malvaceae family members such as marshmallow and ambrette [PMID:30000942].
Grossesse et allaitement
No scientifically valid clinical trials support its use as a galactogogue, and no data exist on the safety and efficacy of Hibiscus for nursing mothers or infants [PMID:30000942].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), with a few review articles (Level C) summarizing phytochemical and pharmacological properties. There are no human clinical trials provided in the abstracts.
Sources PubMed
1.PMID: 37218183 (2024) — A Comprehensive Overview of Hibiscus rosa-sinensis L.: Its Ethnobotanical Uses, Phytochemistry, Therapeutic Uses, Pharmacological Activities, and Toxicology. · Endocrine, metabolic & immune disorders drug targets
2.PMID: 30000942 (2006) — Burden of knee osteoarthritis in China and globally: 1990-2045. · BMC musculoskeletal disorders
3.PMID: 35158612 (2022) — Hibiscus rosa-sinensis Forage as a Potential Feed for Animals: A Review. · Animals : an open access journal from MDPI
4.PMID: 41323831 (2025) — Hibiscus rosa-sinensis: A Multifunctional Flower Bridging Nutrition, Medicine, and Molecular Therapeutics. · Food science & nutrition
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Color, Antioxidant Capacity and Flavonoid Composition in Hibiscus rosa-sinensis Cultivars.
· Molecules (Basel, Switzerland)
6.PMID: 24381420 (2013) — Antidyslipidemic and Antioxidant Activities of Hibiscus rosa sinensis Root Extract in Alloxan Induced Diabetic Rats. · Indian journal of clinical biochemistry : IJCB
7.PMID: 38997637 (2024) — Review of Malaysian medicinal plants with potential wound healing activity. · BMC complementary medicine and therapies
8.PMID: 35352670 (2022) — Antihypertensive and Vasorelaxant Effects of Hibiscus rosa-sinensis through Angiotensin-Converting Enzyme-2 (ACE-2), and Ca2+ Channels Pathways. · Cardiovascular & hematological disorders drug targets
9.PMID: 40330800 (2025) — Phytochemical Analysis, Antibacterial, and Antitumor Potential of Hibiscus rosa-sinensis Linn. · Scientifica
10.PMID: 37720793 (2023) — Plant-Based Bioactive Phthalates Derived from Hibiscus rosa-sinensis: As In Vitro and In Silico Enzyme Inhibition. · ACS omega
11.PMID: 18317554 (2008) — Post-Coital Antifertility Activity of Hibiscus rosa-sinensis Linn. roots. · Evidence-based complementary and alternative medicine : eCAM
12.PMID: 28644857 (2017) — Beneficial effects of Hibiscus rosa-sinensis L. flower aqueous extract in pregnant rats with diabetes. · PloS one