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Not CommonRésumée par IA
Hierba Santa
Piper auritum
Troubles digestifs en médecine populaire mexicaine
PubMed · Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition. (2024)
PubMed · A systematic review of botany, phytochemicals and pharmacological properties of "<i>Hoja sant</i> <i>a</i>" (<i>Piper auritum</i> Kunth). (2021)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Piper auritum, known as Hoja Santa or Hierba Santa, is a Mexican endemic plant used in cuisine and traditional medicine for its antioxidant, antidiabetic, and antimicrobial properties [PMID:32960783, PMID:38409305].
Contexte
Piper auritum Kunth is a large-leafed perennial plant endemic to Mexico and Central America [PMID:24082635, PMID:40137130]. It is characterized by a greenish stem without spots and is often used as a fresh vegetable or condiment in Mexican gastronomy [PMID:39353875, PMID:36417317].
Usages traditionnels
Traditionally used as an aphrodisiac [PMID:30545804], for treating diabetes [PMID:28704049], and as a general remedy in Mexican and Panamanian traditional medicine for various ailments [PMID:32960783, PMID:29428241].
Composés actifs
Phytochemical analysis reveals the presence of safrole (a major component), alpha-copaene, caryophyllene, beta-pinene, gamma-terpinene, and pentadecane [PMID:38520343]. Other identified compounds include benzoic acid derivatives, phenylpropanoids, triterpenoids, triterpene saponins, and nutraceuticals such as trigonelline, myo-inositol, betaine, and choline [PMID:32960783, PMID:36417317, PMID:30263262].
Mécanisme d'action
Antimutagenic effects are attributed to the inhibition of Cytochrome P450 (CYP1A1) activity and direct interaction between plant components and mutagens [PMID:38520343, PMID:40137130]. Antidiabetic effects involve the inhibition of alpha-amylase and alpha-glucosidase, as well as the reduction of oxidative stress by increasing antioxidant enzymes such as SOD, CAT, GPx, and GSH [PMID:30263262, PMID:24082635].
Preuves cliniques
Preuve DDiabetes/Hyperglycemia
Hexane extract significantly reduced blood glucose, serum cholesterol, and triglycerides while increasing HDL-cholesterol and antioxidant enzyme levels in STZ-induced diabetic rats [PMID:24082635, PMID:25141815].
Preuve DSexual Performance
Aqueous extract stimulated ejaculatory behavior and recovered sexual performance in sluggish male rats [PMID:30545804].
Preuve DMutagenesis
Ethanol extract demonstrated significant antimutagenic effects against food-borne aromatic amines and benzo[a]pyrene in Salmonella typhimurium strains [PMID:38520343, PMID:40137130].
Preuve DSnakebite Envenomation
Ethanolic extract neutralized the edematic and coagulant effects caused by Bothrops rhombeatus venom [PMID:31279070].
Preuve DOxidative Stress/Glycation
Hexane extract showed high antioxidant activity and inhibited the formation of advanced glycation end-products (AGEs) in vitro and in diabetic rat models [PMID:23047487, PMID:25141815].
Sécurité et effets indésirables
No specific adverse effects are detailed, though it is noted that some components like safrole are present [PMID:32960783, PMID:38520343].
Grossesse et allaitement
Piper auritum (referred to as anison) is reported as one of the most frequently ingested medicinal plants by pregnant women in primary care, often without medical indication, despite general warnings that some medicinal plants may have abortive or teratogenic potential [PMID:20141666].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (rats/mice), indicating strong potential for antidiabetic, antioxidant, and antimutagenic activities; however, there are no human clinical trials provided in the source material.
Sources PubMed
1.PMID: 38409305 (2024) — Biogenic Ag2O nanoparticles with "Hoja Santa" (Piper auritum) extract: characterization and biological capabilities. · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
2.PMID: 32960783 (2021) — A systematic review of botany, phytochemicals and pharmacological properties of "Hoja sant a" (Piper auritum Kunth). · Zeitschrift fur Naturforschung. C, Journal of biosciences
3.PMID: 36417317 (2022) — 1 H-NMR Metabolomics Profiling and Volatile Content of 'Hoja Santa' (Piper auritum Kunth): A Millenary Edible Plant Consumed in Mexico. · Chemistry & biodiversity
4.PMID: 38520343 (2024) — Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition. · Mutagenesis
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Total phenolics and antioxidant activity of Piper auritum and Porophyllum ruderale.
· Food chemistry
6.PMID: 30545804 (2019) — Piper auritum Kunth (Piperaceae) improves the sexual performance of sluggish male rats through enhancing ejaculation. · Journal of ethnopharmacology
7.PMID: 40137130 (2025) — Studies of Piper auritum Kuntz's Mutagenic and Antimutagenic Properties Using the Ames Test. · Metabolites
8.PMID: 30959974 (2019) — Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications. · Molecules (Basel, Switzerland)
9.PMID: 24082635 (2012) — Effect of the hexane extract of Piper auritum on insulin release from β-cell and oxidative stress in streptozotocin-induced diabetic rat. · Pharmacognosy magazine
10.PMID: 41154079 (2025) — Abiotic Stress Alters the Nutritional, Metabolomic, and Glycomic Profiles of Piper auritum Kunth. · Foods (Basel, Switzerland)
11.PMID: 28704049 (2017) — Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum. · Journal of natural products
12.PMID: 25141815 (2014) — Antidiabetic activity of Piper auritum leaves in streptozotocin-induced diabetic rat, beneficial effect on advanced glycation endproduct. · Chinese journal of integrative medicine
13.PMID: 31279070 (2019) — Edematic and coagulant effects caused by the venom of Bothrops rhombeatus neutralized by the ethanolic extract of Piper auritum. · Journal of ethnopharmacology
14.PMID: 39353875 (2024) — Utilization of Advanced Microscopy Techniques and Energy-dispersive X-ray Spectroscopy to Characterize Three Piper Species Related to Kava. · Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
15.PMID: 29428241 (2018) — Ethnomedical uses and pharmacological activities of most prevalent species of genus Piper in Panama: A review. · Journal of ethnopharmacology
16.PMID: 27695268 (2016) — Anti-Advanced Glycation End-product and Free Radical Scavenging Activity of Plants from the Yucatecan Flora. · Pharmacognosy research
17.PMID: 23047487 (2012) — Evaluation of the antioxidant and anti-glication effects of the hexane extract from Piper auritum leaves in vitro and beneficial activity on oxidative stress and advanced glycation end-product-mediated renal injury in streptozotocin-treated diabetic rats. · Molecules (Basel, Switzerland)
18.PMID: 40482065 (2025) — Piper auritum (Kunth) Fungal Endophytes: A Source of Metabolites to Inhibit the Formation of Advanced Glycation End Products. · Chemistry & biodiversity
19.PMID: 42108661 (2026) — Antifungal Potential of Essential Oils From Native Mexican Species: Chemical Composition and In Vitro Vapor-Phase Analyses. · Chemistry & biodiversity
20.PMID: 30263262 (2016) — Antidiabetic andantioxidant properties, and α-amylase and α-glucosidase inhibition effects of triterpene saponins from Piper auritum. · Food science and biotechnology
21.PMID: 40266814 (2025) — Insecticidal and Repellent Activity of Plant Powders on the Weevil (Sitophilus zeamais) in Stored Corn Grains in a Rural Community of Oaxaca, Mexico. · Insects
22.PMID: 20141666 (2009) — [Use of medicinal plants during pregnancy]. · Revista medica del Instituto Mexicano del Seguro Social