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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Cynoglossum officinale
European biennial of disturbed ground; used in historical European folk medicine for skin conditions and wounds despite containing toxic pyrrolizidine alkaloids.
Hound's Tongue (Cynoglossum officinale) is a biennial plant historically used in European folk medicine for skin conditions and wound healing, but its use is severely limited by the presence of toxic pyrrolizidine alkaloids (PAs) that cause hepatotoxicity. Modern research focuses on the wound-healing properties of allantoin, while PA toxicology studies underscore the dangers of internal use. The plant also contains mucilage and tannins, which contribute to its traditional topical applications.
Allantoin promotes wound healing by stimulating cell proliferation and granulation tissue formation, possibly through activation of fibroblast growth factor receptors and increased collagen synthesis. Pyrrolizidine alkaloids are metabolized by hepatic cytochrome P450 enzymes (CYP3A4) to reactive pyrrole metabolites that form DNA and protein adducts, leading to sinusoidal obstruction syndrome and hepatocyte necrosis. Tannins and mucilage provide astringent and demulcent effects, reducing inflammation and forming a protective barrier on skin lesions.
European biennial of disturbed ground; used in historical European folk medicine for skin conditions and wounds despite containing toxic pyrrolizidine alkaloids.
Hound's Tongue (Cynoglossum officinale) is a biennial plant historically used in European folk medicine for skin conditions and wound healing, but its use is severely limited by the presence of toxic pyrrolizidine alkaloids (PAs) that cause hepatotoxicity. Modern research focuses on the wound-healing properties of allantoin, while PA toxicology studies underscore the dangers of internal use. The plant also contains mucilage and tannins, which contribute to its traditional topical applications.
Allantoin promotes wound healing by stimulating cell proliferation and granulation tissue formation, possibly through activation of fibroblast growth factor receptors and increased collagen synthesis. Pyrrolizidine alkaloids are metabolized by hepatic cytochrome P450 enzymes (CYP3A4) to reactive pyrrole metabolites that form DNA and protein adducts, leading to sinusoidal obstruction syndrome and hepatocyte necrosis. Tannins and mucilage provide astringent and demulcent effects, reducing inflammation and forming a protective barrier on skin lesions.