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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Hu Zhang (Reynoutria japonica), also known as Japanese knotweed, is a traditional Chinese medicinal herb used for inflammatory diseases, infections, and respiratory disorders [PMID:41046083, PMID:35770098].
Contexte
Reynoutria japonica Houtt. (synonym Fallopia japonica) is a perennial herbaceous plant native to East Asia and is recognized as one of the world's most destructive invasive species [PMID:35009007, PMID:39993002]. It is a mixed auto-/allooctoploid plant characterized by aggressive growth and strong adaptability [PMID:39993002].
Usages traditionnels
In traditional Chinese medicine, it is used to invigorate blood, cool heat, resolve toxicity, clear heat in the body, improve blood and qi circulation, eliminate phlegm, and relieve cough [PMID:35770098, PMID:35281919]. It has been traditionally used to treat favus, jaundice, scald, constipation, and liver cancer [PMID:35770098, PMID:40524029].
Composés actifs
The plant contains stilbenes (notably resveratrol and polydatin), anthraquinones (including emodin and emodin-6-O-β-D-glucoside), flavonoids (such as luteolin), and proanthocyanidins/flavan-3-ols (including (-)-epicatechin and procyanidin B2) [PMID:35770098, PMID:34961091, PMID:24114447, PMID:33672472, PMID:31963589].
Mécanisme d'action
Resveratrol inhibits the activation of NLRP3 inflammasomes by promoting mitophagy [PMID:34335041]. Luteolin targets AKT1 to inhibit macrophage apoptosis and mitochondrial damage in the context of acute lung injury [PMID:41046083]. Emodin-6-O-β-D-glucoside attenuates high-glucose-induced vascular inflammation by reducing vascular permeability, monocyte adhesion, ROS formation, and NF-κB activation [PMID:24114447].
Preuves cliniques
Preuve DGouty Arthritis
Resveratrol from R. japonica significantly improves gait score and synovitis in rat models and inhibits MSU-induced peritoneal inflammation [PMID:34335041]
Preuve AAcute Respiratory Tract Infections
A systematic review was conducted to evaluate the effect of R. japonica as a single herb or in formulas for RTIs [PMID:35281919]
Preuve DAcute Lung Injury
Luteolin from R. japonica protects against acute lung injury by inhibiting macrophage apoptosis and mitochondrial damage via AKT1 [PMID:41046083]
Preuve DSARS-CoV-2
A 70% ethanolic extract of the rhizome bark showed a statistically significant antiviral effect against wild-type SARS-CoV-2 in vitro [PMID:36134975]
Preuve CHyperuricemia
R. japonica is identified as a single medicine effective for lowering uric acid [PMID:37193181]
Sécurité et effets indésirables
Hu Zhang has been listed among herbal traditional Chinese medicine products associated with potential hepatotoxicity [PMID:26357619].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (Level D), and systematic reviews of existing trials (Level A), with some general pharmacological reviews (Level C). Most findings are preclinical.
Sources PubMed
1.PMID: 34335041 (2021) — Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes. · Journal of inflammation research
2.PMID: 35281919 (2022) — Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: A Systematic Review. · Frontiers in pharmacology
3.PMID: 35009007 (2021) — Allelopathy of Knotweeds as Invasive Plants. · Plants (Basel, Switzerland)
4.PMID: 34961091 (2021) — New Approaches on Japanese Knotweed (Fallopia japonica) Bioactive Compounds and Their Potential of Pharmacological and Beekeeping Activities: Challenges and Future Directions. · Plants (Basel, Switzerland)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
7.PMID: 33672472 (2021) — Flavan-3-ols and Proanthocyanidins in Japanese, Bohemian and Giant Knotweed. · Plants (Basel, Switzerland)
8.PMID: 26357619 (2014) — Traditional Chinese Medicine Induced Liver Injury. · Journal of clinical and translational hepatology
9.PMID: 35770098 (2022) — The Invasive Species Reynoutria japonica Houtt. as a Promising Natural Agent for Cardiovascular and Digestive System Illness. · Frontiers in pharmacology
10.PMID: 37193181 (2023) — The potential of Chinese medicines in the treatment of hyperuricemia. · American journal of translational research
11.PMID: 41046083 (2026) — Mechanism of Reynoutria Japonica Houtt and its active component luteolin in treating acute lung injury by targeting AKT1 to inhibit macrophage apoptosis and mitochondrial damage. · Journal of ethnopharmacology
12.PMID: 40524029 (2025) — To reveal the key mechanism of Citri Reticulatae Pericarpium-Reynoutria japonica Houtt in the treatment of liver cancer and its correlation with lipid metabolism: synergetic effect with network pharmacology, molecular docking and bioinformatics. · Discover oncology
13.PMID: 36134975 (2022) — Japanese Knotweed Rhizome Bark Extract Inhibits Live SARS-CoV-2 In Vitro. · Bioengineering (Basel, Switzerland)
14.PMID: 31963589 (2020) — Leaves of Invasive Plants-Japanese, Bohemian and Giant Knotweed-The Promising New Source of Flavan-3-ols and Proanthocyanidins. · Plants (Basel, Switzerland)