Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 28 articles PubMed · modèle : gemma4:31b
Résumé
Huang Qi Bei (Astragalus membranaceus var. mongholicus) is a widely used traditional Chinese medicinal plant, primarily utilized for its roots [PMID:30691074, PMID:36244068].
Contexte
Astragalus membranaceus var. mongholicus is a perennial herbaceous plant of the Leguminosae family cultivated in Northwest China [PMID:38276773, PMID:36307985]. The dried roots, known as Astragali Radix, are the primary medicinal part [PMID:35609680, PMID:36307985].
Usages traditionnels
It is used as a traditional Chinese medicine (TCM) and is a component in formulas used to treat insomnia, fatigue, and loss of appetite [PMID:31644940, PMID:36244068].
Composés actifs
Main bioactive constituents include flavonoids (such as calycosin and formononetin), phenolic acids, saponins (including astragalosides), and cycloartane-type triterpenoids [PMID:31890338, PMID:32654511, PMID:36244068, PMID:28501748]. Additionally, pterocarpans and apiosyl-containing pterocarpan glycosides have been isolated from the root [PMID:35609680].
Mécanisme d'action
Some isolated pterocarpans exhibit alpha-glucosidase inhibitory function [PMID:35609680]. Calycosin is associated with antioxidative activity [PMID:36244068]. TCM herbs including A. membranaceus var. mongholicus are reported to modulate the Th17/Treg axis in immune-mediated inflammatory diseases [PMID:32345031].
Preuves cliniques
Preuve AImmune-mediated inflammatory diseases
A systematic review indicates that TCM prescriptions containing A. membranaceus var. mongholicus (found in 5.20% of assessed prescriptions) may modulate the Th17/Treg axis [PMID:32345031]
Preuve DType 1 diabetes mellitus
Integrative TCM therapy, where Huang-qi is a common single herb used, is associated with a reduced risk of diabetic ketoacidosis [PMID:27340102]
Sécurité et effets indésirables
In a toxicological study of the Bei Qi Wu Jia formula (containing Radix Astragali), no evidence of acute toxicity was observed in mice, and no deaths or changes in general behavior were noted in rats during a 28-day subacute study [PMID:31644940].
Synthèse des preuves
The available evidence consists primarily of phytochemical characterizations, genomic studies, and animal-based toxicological assessments. Clinical evidence is limited to systematic reviews of TCM prescriptions and observational data.
Sources PubMed
- 1.PMID: 35609680 (2022) — Bioactive pterocarpans from the root of Astragalus membranaceus var. mongholicus. · Phytochemistry
- 2.PMID: 32654511 (2020) — Cycloartane-type triterpenoids from the root of Astragalus membranaceus var. mongholicus. · Journal of Asian natural products research
- 3.PMID: 30691074 (2019) — Flowers of Astragalus membranaceus var. mongholicus as a Novel High Potential By-Product: Phytochemical Characterization and Antioxidant Activity. · Molecules (Basel, Switzerland)
- 4.PMID: 36244068 (2023) — Identification of characteristic markers for monofloral honey of Astragalus membranaceus var. mongholicus Hsiao: A combined untargeted and targeted MS-based study. · Food chemistry
- 5.PMID: 31890338 (2019) — Comparative analysis of twenty-five compounds in different parts of Astragalus membranaceus var. mongholicus and Astragalus membranaceus by UPLC-MS/MS.