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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Iceland Moss (Cetraria islandica) is a lichen used traditionally for respiratory and digestive conditions, demonstrating antioxidant, immunomodulating, and antiviral properties in experimental studies [PMID:35956939, 37298969].
Contexte
Cetraria islandica is a fruticose or subfoliose lichen primarily distributed in the Northern Hemisphere across North America and Eurasia [PMID:35956939]. It is a symbiotic organism composed of a fungus and a photosynthesizing partner, such as a green alga [PMID:23833245, 29535321].
Usages traditionnels
It has been widely employed in folk medicine for treating digestive and respiratory diseases, specifically as a demulcent for mouth and throat irritations, dry cough, and temporary loss of appetite [PMID:35956939, 36630529]. It is consumed as tea, food ingredients (e.g., soup or bread), and herbal medicines [PMID:29287470].
Composés actifs
Identified compounds include depsidones (fumarprotocetraric and protocetraric acids), depsides, dibenzofuran derivatives (usnic acid), fatty acids (lichesterinic and protolichesterinic acids), and polysaccharides such as lichenan, isolichenan, and galactomannan [PMID:35956939, 36630529, 7646581].
Mécanisme d'action
Lichenan induces terminal cellular differentiation of primary human keratinocytes by upregulating gene clusters related to MAPK signaling [PMID:30031897]. Protolichesterinic acid demonstrates activity against Helicobacter pylori [PMID:8980785]. Polysaccharides exhibit immunostimulating activity by enhancing granulocytic phagocytosis [PMID:7809205, 23195981].
Preuves cliniques
Preuve DInfluenza (A/H3N2 and A/H5N1)
Ethanol and aqueous extracts exhibited in vitro antiviral activity, with ethanol extracts being more potent at lower concentrations [PMID:37464197]
Preuve DOxidative Stress/Diabetes
Aqueous extracts showed ameliorative effects against diabetes-induced genetic and oxidative damage in human blood cells [PMID:23987663] and had no detrimental effects on liver histopathology in diabetic rats [PMID:24193057]
Preuve DGastric/Duodenal Ulcer (H. pylori)
Protolichesterinic acid showed in vitro susceptibility of Helicobacter pylori with MIC ranges of 16 to 64 micrograms/ml [PMID:8980785]
Preuve DGeneral Antioxidant Activity
Aqueous extracts demonstrated higher antioxidant activity and superoxide anion radical scavenging than alpha-tocopherol in linoleic acid emulsions [PMID:11849836]
Sécurité et effets indésirables
Untreated or shortly boiled lichens were found to be lethally toxic to mice [PMID:3468923]. Lichens can concentrate heavy metals and airborne radionuclides (e.g., 210Po), which may pose health risks [PMID:28882460, 3468923]. Methanol extracts have been shown to increase micronucleus frequency in a dose-dependent manner in peripheral blood lymphocytes [PMID:24590925].
Posologie et administration
Traditionally used as decoctions, tinctures, aqueous extracts, and infusions [PMID:35956939]. Pretreatment methods such as ash-soaking have been used to reduce toxicity in animal models [PMID:3468923]. No PubMed data available. Consult a healthcare provider.
Synthèse des preuves
The evidence is primarily based on in vitro studies, animal models, and phytochemical reviews (Level C and D). There are no human clinical trials (Level B) or meta-analyses (Level A) provided in the source material.
Sources PubMed
1.PMID: 35956939 (2022) — The Genus Cetraria s. str.-A Review of Its Botany, Phytochemistry, Traditional Uses and Pharmacology. · Molecules (Basel, Switzerland)
2.PMID: 37464197 (2023) — Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments. · Bulletin of experimental biology and medicine
3.PMID: 29287470 (2018) — Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS chemical profiling and DNA barcoding. · Food chemistry
4.PMID: 37298969 (2023) — Ultrastructural, Energy-Dispersive X-ray Spectroscopy, Chemical Study and LC-DAD-QToF Chemical Characterization of Cetraria islandica (L.) Ach. · Molecules (Basel, Switzerland)
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— Two-step isolation of the two major paraconic acids of Cetraria islandica.
· Journal of separation science
6.PMID: 18053625 (2008) — Susceptibility to acidic precipitation contributes to the decline of the terricolous lichens Cetraria aculeata and Cetraria islandica in central Europe. · Environmental pollution (Barking, Essex : 1987)
7.PMID: 7809205 (1994) — Immunologically active polysaccharide from Cetraria islandica. · Planta medica
8.PMID: 28482319 (2017) — Is there a risk of trace element contamination in herbal preparations? A test study on the lichen Cetraria islandica. · Chemosphere
9.PMID: 23987663 (2013) — The ameliorative effect of Cetraria islandica against diabetes-induced genetic and oxidative damage in human blood. · Pharmaceutical biology
10.PMID: 27064003 (2016) — Secondary metabolites from cetrarioid lichens: Chemotaxonomy, biological activities and pharmaceutical potential. · Phytomedicine : international journal of phytotherapy and phytopharmacology
11.PMID: 33391192 (2020) — The Total and Active Bacterial Community of the Chlorolichen Cetraria islandica and Its Response to Long-Term Warming in Sub-Arctic Tundra. · Frontiers in microbiology
12.PMID: 11849836 (2002) — Determination of antioxidant activity of lichen Cetraria islandica (L) Ach. · Journal of ethnopharmacology
13.PMID: 3468923 (1986) — Toxicity of Iceland lichen and reindeer lichen. · Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
14.PMID: 23833245 (2015) — The effects of Cetraria islandica and Pseudevernia furfuracea extracts in normal and diabetic rats. · Toxicology and industrial health
16.PMID: 24590925 (2014) — Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica. · Cytotechnology
17.PMID: 8980785 (1997) — In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica. · Antimicrobial agents and chemotherapy
18.PMID: 24193057 (2016) — The biochemical and histological effects of lichens in normal and diabetic rats. · Toxicology and industrial health
19.PMID: 38233688 (2024) — Non-photochemical quenching may contribute to the dominance of the pale mat-forming lichen Cladonia stellaris over the sympatric melanic Cetraria islandica. · Oecologia
20.PMID: 40807358 (2025) — Cyclodextrin-Based Systems of Cetraria islandica Extracts: A Novel Approach to Improve Solubility and Biological Activity of Lichen-Derived Natural Products. · Molecules (Basel, Switzerland)
21.PMID: 23195981 (1998) — Immunomodulating polysaccharides from aqueous extracts of Cetraria islandica (Iceland moss). · Phytomedicine : international journal of phytotherapy and phytopharmacology
22.PMID: 24660683 (2014) — Antitrypanosomal activity & docking studies of isolated constituents from the lichen Cetraria islandica: possibly multifunctional scaffolds. · Current topics in medicinal chemistry
23.PMID: 7646581 (1995) — Rational approach to fractionation, isolation, and characterization of polysaccharides from the lichen Cetraria islandica. · Arzneimittel-Forschung
24.PMID: 30031897 (2018) — β-1,3/1,4-Glucan Lichenan from Cetraria islandica (L.) ACH. induces cellular differentiation of human keratinocytes. · Fitoterapia
25.PMID: 33804278 (2021) — Diversity and Physiological Characteristics of Antarctic Lichens-Associated Bacteria. · Microorganisms
26.PMID: 28882460 (2018) — Elemental and radiological characterization of commercial Cetraria islandica (L.) Acharius pharmaceutical and food supplementation products. · The Science of the total environment