Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 21 articles PubMed · modèle : gemma4:31b
Résumé
Contexte
Usages traditionnels
Composés actifs
Mécanisme d'action
Preuves cliniques
Methanolic root extract (50 mg/kg) reduced blood glucose by up to 58.84% and promoted pancreatic beta-cell regeneration in diabetic rats [PMID:30636828]. Polyphenol leaf extract (150-300 mg/kg) reversed dexamethasone-induced hyperglycemia in rats [PMID:26215014].
Methanol root extract (200-400 mg/kg) protected rats in MES, PTZ, and INH-induced convulsion models [PMID:27379268].
Methanol extract (400 mg/kg) significantly reduced total cholesterol and triglycerides in triton WR-1339-induced and high-fat diet animals [PMID:21591834]. Active sub-fractions from leaves decreased lipid accumulation and body weight gain in HFD-induced obese mice [PMID:26602455].
Polyphenolic leaf extract increased the lifespan of animals with murine Ehrlich ascites carcinoma by 53.41% to 73.95% [PMID:17704739]. Root extracts and isolated triterpenes showed cytotoxicity against MCF-7, BEL-7402, SPC-A-1, and SGC-7901 cancer cell lines [PMID:24374448].
Root-derived phyto-steroids demonstrated anti-inflammatory and analgesic efficacy in vitro and in vivo [PMID:30217788].
Sécurité et effets indésirables
Synthèse des preuves
Sources PubMed
- 1.PMID: 37615387 (2024) — Phytochemical profiling and evaluation of the antidiabetic potential of Ichnocarpus frutescens (Krishna Sariva): kinetic study, molecular modelling, and free energy approach. · Journal of biomolecular structure & dynamics
- 2.PMID: 30636828 (2018) — Antidiabetic potential of active fraction obtained from methanolic extract of Ichnocarpus frutescens: A possible herbal remedy. · Indian journal of pharmacology
- 3.PMID: 27379268 (2014) — Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats. · International scholarly research notices
- 4.PMID: 21264156 (2008) — Antidiabetic activity of aqueous root extract of Ichnocarpus frutescens in streptozotocin-nicotinamide induced type-II diabetes in rats. · Indian journal of pharmacology
- 5.PMID: 23961196