Jin Qian Cao (Lysimachia christinae): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Jin Qian Cao work to treat gallstones?

Jin Qian Cao (Lysimachia christinae) contains active compounds including flavonoids, phenolic acids, and triterpenoids that promote bile secretion and relax smooth muscle in the biliary tract. These compounds help dissolve cholesterol-based gallstones and facilitate their passage. The herb also exhibits anti-inflammatory and diuretic properties, which support urinary stone expulsion. Traditional Chinese Medicine classifies it as clearing damp-heat, explaining its dual action on both gallbladder and urinary systems. Evidence Level: C.

Does Jin Qian Cao interact with any medications?

Jin Qian Cao may interact with medications affecting the liver or gallbladder, including cholesterol-lowering drugs and bile acid sequestrants. Due to its diuretic properties, it could potentially enhance the effects of diuretic medications, affecting electrolyte balance. Limited pharmacokinetic data exists for this herb, so patients taking prescription medications should consult a qualified healthcare provider before use. Always disclose all supplements to your physician to prevent potential interactions. Evidence Level: Traditional/C.

What is the correct dosage for Jin Qian Cao?

The typical adult dosage for Jin Qian Cao is 15-60 grams of fresh herb or 30-60 grams of dried herb when prepared as a decoction. Lower doses are used for mild conditions, while higher doses may be prescribed for acute stone expulsion. The herb is commonly boiled in water and consumed as tea. Dosage should be individualized by a qualified TCM practitioner based on your specific condition, constitution, and other treatments. Evidence Level: Traditional.

Is Jin Qian Cao safe during pregnancy?

Jin Qian Cao is contraindicated during pregnancy and should be avoided. The herb promotes downward movement and stimulates smooth muscle contraction, which may pose a risk of miscarriage or premature labor. Additionally, its strong draining properties may deplete qi and fluids, which are essential to maintain during pregnancy. Women who are pregnant, nursing, or attempting to conceive should not use this herb without explicit guidance from a qualified healthcare provider. Evidence Level: Traditional.

Can Jin Qian Cao dissolve gallstones naturally?

Jin Qian Cao has been traditionally used to help expel gallstones and may support the dissolution of smaller cholesterol-based stones. Its active compounds promote bile flow and relax biliary smooth muscle, potentially aiding stone passage. However, clinical evidence remains limited (Level C), and this herb should not replace medical treatment for large or symptomatic gallstones. Patients with gallbladder disease should work with a healthcare provider to determine appropriate treatment options.

What are the side effects of Jin Qian Cao?

Jin Qian Cao is generally well-tolerated at recommended doses. The most commonly reported side effect is mild gastrointestinal upset, particularly at higher doses. The herb's draining nature may cause fatigue or weakness in individuals with Spleen qi deficiency, who should avoid this herb. Prolonged use at high doses may deplete body fluids. Discontinue use if you experience persistent digestive discomfort, dizziness, or other adverse reactions. Evidence Level: Traditional.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Jin Qian Cao (Lysimachia christinae) is a traditional Chinese medicinal herb used primarily for treating urinary disorders, kidney and gallstones, and liver-related conditions [PMID:33553641, 25794804, 40692330].

Contexte

Lysimachia christinae Hance is a medicinal plant widely distributed in subtropical China at elevations from 500-2300m [PMID:33553641]. It is a member of the Primulaceae family [PMID:33553641, 37452336].

Usages traditionnels

Traditionally used in Chinese medicine for treating jaundice, urinary disorders, the liver, cholelithiasis (gallstones), and for its diuretic, detumescent, and detoxifying effects [PMID:33553641, 25794804, 29636055].

Composés actifs

Active components include polysaccharides [PMID:37419267], triterpene saponins (such as lysichriside A and B) [PMID:18335347], flavonoids (specifically rutin and quercetin) [PMID:33133573, 22621991], and chlorogenic acid [PMID:36963520].

Mécanisme d'action

Mechanisms include modulating the gut microbes-mediated FXR-FGF15 signaling pathway to reduce hyperlipidemia [PMID:37419267], inhibiting the PI3K/Akt/mTOR pathway to ameliorate renal injury [PMID:40692330], suppressing NADPH oxidase subunits and enhancing eNOS phosphorylation for vascular relaxation [PMID:31055581], and activating the Nrf2/ARE antioxidant pathway to protect renal tissue [PMID:34603474].

Preuves cliniques

Preuve DCholelithiasis (Gallstones)

Aqueous extract almost entirely eliminated preestablished cholesterol gallstones in mice and promoted bile secretion [PMID:25794804].

Preuve DNephrolithiasis (Kidney Stones)

Aqueous extract and rutin reduced renal calcium oxalate deposition and renal tissue injury in rat and mouse models [PMID:40692330, 40063111, 42193124].

Preuve DHyperlipidemia

Polysaccharides reduced cholesterol and triglyceride levels in high-fat diet mice via gut microbiota modulation [PMID:37419267].

Preuve DHyperuricemia

Aqueous extract elicited dose-dependent hypouricemic effects in oxonate-induced hyperuricemic mice [PMID:12776538].

Preuve DAlcohol-induced liver injury

Ethanolic extract and quercetin significantly reduced serum ALT and AST activities in mice [PMID:22621991].

Preuve DBreast Cancer (In vitro)

Extract and rutin decreased proliferation and viability of MCF-7 and HCC38 human breast cancer cells [PMID:33133573].

Sécurité et effets indésirables

In mice, a single dose of aqueous extract up to 50g material/kg body weight did not lead to death or significant changes in body weight, visceral organ indexes, or blood biochemical indexes [PMID:25794804].

Interactions médicamenteuses

Used in combination with Tripterygium wilfordii Hook. f. to reduce the toxicity of triptolide and mitigate multi-organ injury [PMID:36339610, 36963520, 29950302].

Synthèse des preuves

The current evidence is based primarily on in vitro studies and animal models (mice, rats, guinea pigs), indicating a low overall clinical evidence level (Level D). No human clinical trials were provided.

Sources PubMed

1.PMID: 37419267 (2023) — Lysimachia christinae polysaccharide attenuates diet-induced hyperlipidemia via modulating gut microbes-mediated FXR-FGF15 signaling pathway. · International journal of biological macromolecules
2.PMID: 18335347 (2008) — Triterpene saponins from Lysimachia christinae. · Journal of Asian natural products research
3.PMID: 31055581 (2019) — The Effects of Lysimachia christinae Hance Extract Fractions on Endothelium-Dependent Vasodilatation. · Pharmacology
4.PMID: 25794804 (2015) — Lysimachia christinae Hance regresses preestablished cholesterol gallstone in mice. · Journal of ethnopharmacology
5.PMID: 29636055 (2018) — Evaluation of the antioxidant and endothelial protective effects of Lysimachia christinae Hance (Jin Qian Cao) extract fractions.

Jin Qian Cao

Sources et citations

Calculer une dose sûre de Jin Qian Cao

Curcuma wenyujin

Dictamnus Albus

Gmelina Arborea

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Jin Qian Cao

Sources et citations

Calculer une dose sûre de Jin Qian Cao

Plantes associées

Curcuma wenyujin

Dictamnus Albus

Gmelina Arborea

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales