Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
JR
Not CommonGénéré par IA
Juglans Regia Herb
Juglans regia
skin conditions and fungal infections in European folk medicine
How does Juglans regia work as an antifungal and astringent?
Juglans regia contains juglone, a naphthoquinone compound with documented antimicrobial and antifungal properties that disrupt fungal cell metabolism. The high tannin content provides astringent effects by binding to proteins and tightening tissue, while ellagic acid and quercetin contribute anti-inflammatory and antioxidant activity. These compounds work synergistically to support the herb's traditional use for skin conditions and fungal infections. Evidence level: C.
Does Juglans regia interact with diabetes medications?
Juglans regia may have blood glucose-lowering effects and could potentially enhance the action of antidiabetic medications such as metformin, sulfonylureas, or insulin, increasing the risk of hypoglycemia. Patients managing diabetes should monitor blood sugar levels closely if using walnut leaf preparations and consult a healthcare provider before combining with conventional diabetes treatment. Evidence level: C based on preliminary research.
What is the recommended dosage for Juglans regia leaf tea?
The standard adult dosage for Juglans regia is 2-4 grams of dried leaf prepared as an infusion (tea) taken internally, or as a cooled topical wash for skin conditions. For external use, the prepared tea can be applied as a compress or wash to affected areas. Internal use should be limited to short durations. Consult a qualified healthcare practitioner for personalized dosing guidance.
Is Juglans regia safe during pregnancy and breastfeeding?
Juglans regia is considered unsafe during pregnancy and breastfeeding. The juglone content may stimulate uterine contractions and potentially affect fetal development. Insufficient safety data exists for lactation use. Pregnant and nursing individuals should avoid walnut leaf, hull, and bark preparations entirely. Those with a history of miscarriage should be particularly cautious. Consult a qualified healthcare provider for safer alternatives.
Can I use Juglans regia if I have a tree nut allergy?
Individuals with tree nut allergies should avoid Juglans regia preparations due to potential cross-reactivity. Walnut tree leaves, hulls, and bark contain proteins that may trigger allergic reactions in sensitive individuals, including skin reactions, respiratory symptoms, or anaphylaxis. Those with known walnut or pecan allergies should exercise particular caution and consult an allergist before use.
What are the side effects of Juglans regia leaf and hull preparations?
The most common side effect is skin staining from juglone, which produces a temporary brownish discoloration. Rare allergic reactions may occur, particularly in those with nut allergies. Internal use may cause gastrointestinal upset in some individuals. People with kidney disease should avoid internal use due to potential nephrotoxic effects. Discontinue use if rash, itching, or other adverse reactions develop.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Juglans regia (English or Persian walnut) is a widely cultivated tree valued for its edible nuts, high-quality wood, and traditional medicinal applications [PMID: 36477175, 27641607].
Contexte
Juglans regia L. is a temperate deciduous fruit tree known as the English or Persian walnut [PMID: 35185955, 27641607]. It is economically important worldwide for its nuts and hardwood [PMID: 36477175].
Usages traditionnels
Since ancient times, various parts of J. regia have been used in traditional medicine to treat microbial infections, stomach ache, thyroid dysfunctions, cancer, heart diseases, sinusitis, helminthiasis, diarrhea, arthritis, asthma, eczema, scrofula, skin disorders, diabetes mellitus, and anorexia [PMID: 30931854, 27641607].
Walnut-derived compounds may ameliorate inflammatory bowel disease by modulating intestinal mucosa permeability, regulating inflammatory pathways (NF-kB, COX/COX2, MAPCK/MAPK, and iNOS/NOS), relieving oxidative stress, and modulating gut microbiota [PMID: 39203780]. Neuroprotective effects are attributed to the decrease of oxidative stress, inflammation, apoptosis, proteolysis, beta-amyloid plaque accumulation, and acetylcholinesterase (AChE) activity [PMID: 39539440].
Preuves cliniques
Preuve BHyperlipidemia
Consumption of 20 g/day of Persian walnut for 8 weeks decreased plasma triglyceride levels by approximately 17% and significantly increased HDL-cholesterol [PMID: 16193197, 12934760].
Preuve CCardiovascular Risk Factors
Walnut bioactive ingredients (omega-3 fatty acids, antioxidants, fiber, and polyphenols) have been demonstrated to improve lipid profiles and blood pressure [PMID: 39803290].
Preuve DWound Healing
In a rat incision wound model, walnut green husk (WGH) extract demonstrated wound-healing potential [PMID: 32499880].
Sécurité et effets indésirables
Walnuts contain major food allergens, including the 2S albumin seed storage protein Jug r 1, which can cause life-threatening allergic reactions in sensitized individuals [PMID: 11799381, 24382327]. Potential side effects of walnut consumption include rash and pruritus [PMID: 12934760].
Synthèse des preuves
Evidence ranges from traditional use and in vitro/in vivo animal studies (D) to clinical trials (B) specifically regarding lipid-lowering effects. Much of the pharmacological data is currently based on reviews (C) of phytochemical properties.
Sources PubMed
1.PMID: 35185955 (2021) — Persian Walnut (Juglans regia L.) Bud Dormancy Dynamics in Northern Patagonia, Argentina. · Frontiers in plant science
2.PMID: 11799381 (2002) — Linear IgE epitope mapping of the English walnut (Juglans regia) major food allergen, Jug r 1. · The Journal of allergy and clinical immunology
3.PMID: 36477175 (2022) — Domestication and selection footprints in Persian walnuts (Juglans regia). · PLoS genetics
4.PMID: 30931854 (2019) — Evaluation and Exploitation of Bioactive Compounds of Walnut, Juglans regia. · Current pharmaceutical design
5.PMID: 27641607 (2016) — Phytochemical profile and biological activity of Juglans regia. · Journal of integrative medicine
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
PMID: 36836737 (2023) — Juglans regia Linn.: A Natural Repository of Vital Phytochemical and Pharmacological Compounds. · Life (Basel, Switzerland)
7.PMID: 20586084 (2010) — Walnut (Juglans regia L.): genetic resources, chemistry, by-products. · Journal of the science of food and agriculture
8.PMID: 35807604 (2022) — Genetic Diversity and Structure of Persian Walnut (Juglans regia L.) in Pakistan: Implications for Conservation. · Plants (Basel, Switzerland)
9.PMID: 35539719 (2018) — Walnut (Juglans regia L.) shell pyroligneous acid: chemical constituents and functional applications. · RSC advances
10.PMID: 39203780 (2024) — Regulation of Intestinal Inflammation by Walnut-Derived Bioactive Compounds. · Nutrients
11.PMID: 39126687 (2024) — Preparation, characterization and microencapsulation of walnut (Juglans regia L.) peptides-zinc chelate. · Journal of food science
12.PMID: 24382327 (2014) — Walnut allergens: molecular characterization, detection and clinical relevance. · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
13.PMID: 36978850 (2023) — Phytochemicals and Biological Activities of Walnut Septum: A Systematic Review. · Antioxidants (Basel, Switzerland)
14.PMID: 30441778 (2018) — Natural Products to Fight Cancer: A Focus on Juglans regia. · Toxins
15.PMID: 42196369 (2026) — Evaluation of Antioxidant Activity and Physicochemical Characterization of Walnut (Juglans regia L.) Oil. · International journal of molecular sciences
16.PMID: 36369998 (2022) — Research progress on Walnut oil: Bioactive compounds, health benefits, extraction methods, and medicinal uses. · Journal of food biochemistry
17.PMID: 39539440 (2024) — Neuroprotective effects of walnut (Juglans regia L.) in nervous system disorders: A comprehensive review. · Iranian journal of basic medical sciences
18.PMID: 25388987 (2014) — Characterization of low molecular weight allergens from English walnut (Juglans regia). · Journal of agricultural and food chemistry
19.PMID: 36096735 (2022) — Genome-wide association analysis of 101 accessions dissects the genetic basis of shell thickness for genetic improvement in Persian walnut (Juglans regia L.). · BMC plant biology
20.PMID: 32499880 (2020) — Wound healing effects of Persian walnut (Juglans regia L.) green husk on the incision wound model in rats. · European journal of translational myology
21.PMID: 33050347 (2020) — Proteome Analysis of Walnut Bacterial Blight Disease. · International journal of molecular sciences
23.PMID: 39803290 (2025) — Nutritional Advantages of Walnut (Juglans regia L.) for Cardiovascular Diseases: A Comprehensive Review. · Food science & nutrition
24.PMID: 37528348 (2023) — Selecting the superior late-leafing genotypes of Persian walnut (Juglans regia L.) using morphological and pomological evaluations. · BMC plant biology
25.PMID: 36596107 (2023) — Phenolic compounds in walnut pellicle improve walnut (Juglans regia L.) protein solubility under pH-shifting condition. · Food research international (Ottawa, Ont.)
26.PMID: 33584750 (2020) — Genome-Wide Association Study Reveals Candidate Genes Involved in Fruit Trait Variation in Persian Walnut (Juglans regia L.). · Frontiers in plant science