Kantkari (Solanum xanthocarpum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Kantkari work for asthma and respiratory conditions?

Kantkari (Solanum xanthocarpum) exhibits bronchodilatory effects primarily through its alkaloid compounds, including solanine and solasonine. These compounds help relax bronchial smooth muscles, reducing airway resistance and easing breathing difficulty. The herb also demonstrates anti-inflammatory properties that may help reduce airway inflammation associated with asthma. Additionally, Kantkari contains saponins that contribute to its expectorant action, helping to clear mucus from respiratory passages. Evidence Level: C (preclinical studies support these mechanisms, though human clinical trials remain limited).

Does Kantkari interact with any medications?

Kantkari may interact with central nervous system depressants due to its potential sedative effects, which can cause drowsiness. Concurrent use with antihistamines, sedatives, or sleep medications may enhance drowsiness and should be approached with caution. The herb's steroidal compounds suggest potential interactions with corticosteroid medications, though clinical evidence is limited. Patients taking prescription bronchodilators should consult a healthcare provider before combining with Kantkari, as additive effects may occur. Always inform your healthcare provider about all herbal supplements.

What is the recommended dosage of Kantkari for adults?

The typical adult dosage of Kantkari is 2-4 grams of dried powder daily, or 500mg of standardized extract taken twice daily. In Ayurvedic practice, it is often administered as a decoction (kwath) or as part of the Dashamoola formulation. Dosage may vary based on the specific condition being treated and the form of preparation used. Children should only use Kantkari under professional supervision. Always follow manufacturer instructions on product labels or consult a qualified Ayurvedic practitioner for personalized dosing recommendations.

Is Kantkari safe during pregnancy and breastfeeding?

Kantkari is considered unsafe during pregnancy and should be strictly avoided. The herb contains steroidal alkaloids, including solanine, which may have uterine-stimulating properties and potentially cause harm to the developing fetus or trigger premature contractions. There is insufficient safety data regarding use during breastfeeding, so nursing mothers should also avoid this herb. Women who are pregnant, planning pregnancy, or breastfeeding should consult a qualified healthcare provider before using any herbal supplements containing Kantkari or Solanum xanthocarpum.

What are the main uses of Kantkari in Ayurvedic medicine?

Kantkari is primarily used in Ayurveda for respiratory conditions including asthma, chronic cough, and bronchitis. It is valued for its bronchodilatory and expectorant properties that help clear airways and ease breathing difficulties. The herb is also traditionally used to reduce fever and treat urinary disorders, including urinary tract infections and dysuria. As a key ingredient in the Dashamoola formulation, Kantkari contributes to broader anti-inflammatory and analgesic effects. Evidence Level: C (traditional use is well-documented, but clinical evidence remains limited).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Solanum xanthocarpum (Kantkari) is a traditional medicinal herb used in Ayurveda and Siddha systems, exhibiting anti-inflammatory, antiasthmatic, and antioxidant properties [PMID: 29568195, 28052238, 32397194].

Contexte

Solanum xanthocarpum is a member of the dashamula (ten roots) in the Ayurvedic system of medicine [PMID: 28052238]. It is a diffuse herb characterized by a prickly stem [PMID: 24991071].

Usages traditionnels

Traditionally used in Ayurveda and Siddha for treating respiratory diseases, cough, fever, heart disorders, skin infections, and inflammation [PMID: 10433479, 28052238, 38825191]. It is also used for relief of burning sensations in the feet with vesicular eruptions [PMID: 28052238].

Composés actifs

Phytochemicals include alkaloids, polyphenols, steroids, chlorogenic acid, and glycoalkaloids such as demissidine [PMID: 29984407, 38825191]. Specific isolated compounds include 18 bioactive lipids (sphingolipids, oxylipins, and phenolic lipids) [PMID: 35085725], various phenolic components [PMID: 37165597], and steroidal saponins (solasaponins A-H) [PMID: 35398090].

Mécanisme d'action

The herb demonstrates anti-inflammatory activity by inhibiting nitric oxide (NO) release in LPS-induced RAW 264.7 cells [PMID: 35085725, 37165597]. It also exhibits antioxidant effects and inhibits thrombin activity and generation [PMID: 23112535, 29568195].

Preuves cliniques

Preuve BBronchial Asthma

A single 300 mg dose of whole plant powder significantly improved pulmonary function parameters (FVC, FEV1, PEFR, FEF25-75%), though the effect was less than standard bronchodilators [PMID: 10433479].

Preuve BBronchial Asthma

Kantakari Avaleha and its granule form were evaluated for efficacy in managing mild to moderate bronchial asthma [PMID: 38075186].

Preuve DNephrolithiasis (Rat Model)

Fruit extract decreased hyperoxaluria, calcium, and uric acid, improved renal function, and produced antioxidant effects [PMID: 23112535].

Preuve DDiabetes (Rat Model)

Methanol leaf extracts (200 mg/kg bw) acted as efficient antihyperglycemic agents with potent antioxidant activity [PMID: 22014732].

Preuve DPsoriasis (Mouse Model/In Vitro)

Ethanolic stem extract showed anti-psoriatic potential in Imiquimod-induced mice [PMID: 28052238] and in human HaCaT keratinocytes [PMID: 39032661].

Preuve D

Sécurité et effets indésirables

In a pilot study for bronchial asthma, no untoward effects were reported [PMID: 10433479]. Stem extract safety was assessed via acute oral toxicity and skin irritability studies [PMID: 28052238].

Synthèse des preuves

Evidence is primarily based on preclinical animal models (D) and in vitro studies, with limited clinical pilot data (B) supporting its use in bronchial asthma.

Sources PubMed

1.PMID: 29568195 (2018) — Evaluation of Antithrombotic Activities of Solanum xanthocarpum and Tinospora cordifolia. · Pharmacognosy research
2.PMID: 37110723 (2023) — Bioprospective Role of Ocimum sanctum and Solanum xanthocarpum against Emerging Pathogen: Mycobacterium avium Subspecies paratuberculosis: A Review. · Molecules (Basel, Switzerland)
3.PMID: 23112535 (2012) — Antiurolithiatic Effects of Solanum xanthocarpum Fruit Extract on Ethylene-Glycol-Induced Nephrolithiasis in Rats. · Journal of young pharmacists : JYP
4.PMID: 39032661 (2024) — Anti-psoriatic potential of medicinal plants, Alstonia scholaris, Wrightia tinctoria, and Solanum xanthocarpum, using human HaCaT keratinocytes by multi-parametric analysis. · Journal of ethnopharmacology
5.PMID: 10433479 (1999) — A pilot study on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma.

Kantkari

Sources et citations

Calculer une dose sûre de Kantkari