Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Katrafay work for pain and fatigue relief?
Katrafay (Cedrelopsis grevei) contains bioactive sesquiterpenes, including ishwarone, copaborneol, and cryptomerione, which are believed to provide its analgesic and anti-inflammatory effects. These compounds may modulate inflammatory pathways and offer muscle-relaxant properties, though the precise mechanism has not been fully established in clinical studies. Traditional use in Madagascar supports its application for muscle pain, rheumatism, and fatigue recovery. Evidence level: C (preliminary evidence from ethnobotanical and phytochemical studies).
Is Katrafay safe to use during pregnancy and breastfeeding?
Katrafay is contraindicated during pregnancy and breastfeeding. Traditional use includes post-partum recovery, suggesting potential effects on uterine function. The essential oil contains concentrated bioactive sesquiterpenes that may stimulate uterine contractions or pass into breast milk, posing risks to the developing fetus or nursing infant. Pregnant and nursing individuals should avoid all forms of Katrafay, including teas and topical applications. Evidence level: C, based on traditional contraindications.
Does Katrafay interact with any medications?
There is limited clinical data on Katrafay drug interactions. Due to its traditional use as a stimulant and restorative tonic, it may theoretically interact with medications affecting the central nervous system or drugs metabolized by hepatic pathways. The essential oil form may enhance effects of topical medications when applied concurrently. Patients taking prescription medications should consult a qualified healthcare provider before using Katrafay products. Evidence level: C.
What is the recommended dosage for Katrafay bark?
Traditional preparations of Katrafay bark typically use 2-3 grams of dried bark prepared as a decoction or tea, taken once or twice daily. For topical use, the essential oil should be properly diluted in a carrier oil at 2-5% concentration before massage application. There is no standardized clinical dosage established from controlled trials. Users should begin with lower amounts and adhere to traditional preparation methods. Evidence level: C.
What is Katrafay used for in traditional Malagasy medicine?
Katrafay bark has been used traditionally in Madagascar for fatigue, muscle pain, rheumatism, fever, and post-partum recovery. It is valued as a general tonic and restorative herb, commonly prepared as a tea or used topically as diluted essential oil for massage. The bark is traditionally believed to support physical recovery and reduce discomfort associated with muscular and joint conditions. Evidence level: C, based on ethnobotanical documentation.
What are the side effects of Katrafay essential oil?
Reported side effects of Katrafay are primarily skin irritation when the essential oil is applied undiluted or in high concentrations. Proper dilution in a carrier oil significantly reduces this risk. Internal use of the tea may cause mild gastrointestinal discomfort in sensitive individuals. There are no documented serious adverse effects in traditional use records, though comprehensive safety studies remain limited. Evidence level: C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 17 articles PubMed · modèle : gemma4:31b
Résumé
Cedrelopsis grevei is an aromatic medicinal plant from Madagascar used in folk medicine [PMID: 15032374, PMID: 23459148].
Contexte
Cedrelopsis grevei Baill. (Ptaeroxylaceae) is a plant native to Madagascar, with significant populations located in the south of the country [PMID: 24591320, PMID: 18325702].
Usages traditionnels
In Madagascar, the trunk bark extract is empirically used to treat various pathologies, including hypertension and persistent catarrh [PMID: 18325702].
Composés actifs
The plant contains various secondary metabolites: the bark contains coumarins (including isocedrelopsin, 3',4'-dihydrobraylin, microfolicoumarin, obliquin, 8-methoxyobliquin, aesculetin, cedrelopsin, scoparone, cedrecoumarin A and B, and norbraylin) [PMID: 14630167, PMID: 12453517], triterpenoid derivatives (cedashnine), and quassinoids (cedphiline, cedmiline) [PMID: 12943787]. Seeds contain chalcones such as uvangoletin, 5,7-dimethylpinocembrin, cardamonin, flavokawin B, 2'-methoxyhelikrausichalcone, cedreprenone, and cedrediprenone [PMID: 12648541]. Essential oils from the bark include beta-pinene, cis-sesquisabinene hydrate, caryophyllene oxide, 4-epi-cis-dihydroagarofuran, and ishwarol B [PMID: 15032374, PMID: 15248260, PMID: 15809968], while leaf essential oils are dominated by trans-beta-farnesene, beta-pinene, cis-sesquisabinene hydrate, and ar-curcumene [PMID: 15032374].
Mécanisme d'action
C. grevei may improve endothelial vasodilatation by increasing the participation of nitric oxide (NO) and increasing the protein expression of Cu/Zn superoxide dismutase (SOD) [PMID: 18325702, PMID: 14551050].
Preuves cliniques
Preuve DHypertension/Blood Pressure
Oral administration of C. grevei extract in rats prevented the increase of systolic blood pressure (SBP) in aged rats and induced a progressive decrease in SBP in normotensive rats [PMID: 18325702, PMID: 14551050]
Preuve DHepatotoxicity
Methanolic extract of C. grevei leaves demonstrated antioxidant and hepatoprotective effects against cypermethrin-induced oxidative stress and liver damage in male mice [PMID: 26209317]
Preuve DCancer (MCF-7 cell lines)
Leaf essential oil showed cytotoxic activity against human breast cancer cells (IC50=21.5 mg/L) [PMID: 23459148]
The current evidence consists primarily of in vitro studies and animal models (rats and mice), indicating potential antihypertensive, hepatoprotective, and cytotoxic properties. There are no human clinical trials provided.
Sources PubMed
1.PMID: 36364121 (2022) — Beyond the Bark: An Overview of the Chemistry and Biological Activities of Selected Bark Essential Oils. · Molecules (Basel, Switzerland)
2.PMID: 24591320 (2014) — Bark essential oil of Cedrelopsis grevei from Madagascar: investigation of steam-distillation conditions. · Chemistry & biodiversity
3.PMID: 14630167 (2003) — New coumarins from Cedrelopsis grevei. · Fitoterapia
5.PMID: 18325702 (2008) — Cedrelopsis grevei improves endothelial vasodilatation in aged rats through an increase of NO participation. · Journal of ethnopharmacology
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
7.PMID: 26209317 (2015) — Antioxidant activity and hepatoprotective potential of Cedrelopsis grevei on cypermethrin induced oxidative stress and liver damage in male mice. · BMC complementary and alternative medicine
8.PMID: 12648541 (2003) — Chalcones from the seed of Cedrelopsis grevei (Ptaeroxylaceae). · Phytochemistry
9.PMID: 15032374 (2004) — Comparative analysis by gas chromatography-mass spectrometry of the essential oils from bark and leaves of Cedrelopsis grevei Baill, an aromatic and medicinal plant from Madagascar. · Journal of chromatography. A
10.PMID: 12624830 (2003) — Vasorelaxing properties and bio-guided fractionation of Cedrelopsis grevei. · Planta medica
11.PMID: 15248260 (2004) — Dihydroagarofurans: the fourth isomer isolated from Cedrelopsis grevei bark oil. · Magnetic resonance in chemistry : MRC
12.PMID: 23459148 (2013) — Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
13.PMID: 14551050 (2004) — Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression. · American journal of physiology. Heart and circulatory physiology
14.PMID: 28122144 (2017) — Chemical Composition and Behavioral Effects of Five Plant Essential Oils on the Green Pea Aphid Acyrthosiphon pisum (Harris) (Homoptera: Aphididae). · Chemistry & biodiversity
15.PMID: 28279184 (2017) — The most used medicinal plants by communities in Mahaboboka, Amboronabo, Mikoboka, Southwestern Madagascar. · Journal of ethnobiology and ethnomedicine
16.PMID: 15809968 (2005) — Isolation and structure elucidation of ishwarol B. · Magnetic resonance in chemistry : MRC