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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Khaya senegalensis
An African mahogany tree whose bark is widely used in West African traditional medicine for malaria and fever.
Khaya senegalensis, an African mahogany tree, is widely used in West African traditional medicine primarily as an antimalarial and anti-inflammatory agent. Its bark contains bioactive limonoids, including gedunin and khayanolides, which contribute to its antipyretic and anthelmintic properties. Clinical evidence remains limited, but traditional use and preliminary studies support its efficacy for fever and parasitic infections.
The antimalarial mechanism is attributed to gedunin, a limonoid that inhibits Plasmodium falciparum growth by targeting heat shock protein 90 (Hsp90) and disrupting parasite protein folding. Anti-inflammatory effects involve suppression of NF-κB and COX-2 pathways, reducing prostaglandin synthesis. Tannins and khayanolides provide antioxidant activity through free radical scavenging and modulation of Nrf2 signaling. Anthelmintic action likely results from disruption of worm neuromuscular function via tannin-induced protein precipitation.
An African mahogany tree whose bark is widely used in West African traditional medicine for malaria and fever.
Khaya senegalensis, an African mahogany tree, is widely used in West African traditional medicine primarily as an antimalarial and anti-inflammatory agent. Its bark contains bioactive limonoids, including gedunin and khayanolides, which contribute to its antipyretic and anthelmintic properties. Clinical evidence remains limited, but traditional use and preliminary studies support its efficacy for fever and parasitic infections.
The antimalarial mechanism is attributed to gedunin, a limonoid that inhibits Plasmodium falciparum growth by targeting heat shock protein 90 (Hsp90) and disrupting parasite protein folding. Anti-inflammatory effects involve suppression of NF-κB and COX-2 pathways, reducing prostaglandin synthesis. Tannins and khayanolides provide antioxidant activity through free radical scavenging and modulation of Nrf2 signaling. Anthelmintic action likely results from disruption of worm neuromuscular function via tannin-induced protein precipitation.