Korean Angelica Root (Angelica gigas): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Korean Angelica Root work in the body?

Korean Angelica Root contains active compounds called decursin and decursinol, which are responsible for many of its therapeutic effects. These compounds exhibit anti-inflammatory properties by modulating inflammatory pathways in the body. The herb also contains nodakenin and umbelliferone, which contribute to its blood-tonic and circulatory-supporting actions. In Traditional Korean Medicine (Hanbang), it is classified as a blood-moving herb that promotes circulation and nourishes blood. Evidence Level: C.

Can I take Korean Angelica Root with blood thinners or anticoagulants?

Korean Angelica Root should not be taken with anticoagulant medications such as warfarin, heparin, or antiplatelet drugs. As a blood-moving herb, it may enhance the effects of blood-thinning medications and increase the risk of bleeding. This interaction is significant because the herb promotes blood circulation and may affect clotting factors. If you are taking prescription anticoagulants, consult your healthcare provider before using this herb. Evidence Level: Traditional/Contraindicated.

What is the recommended dosage for Korean Angelica Root?

The typical adult dosage for Korean Angelica Root is 3-9 grams of dried root prepared as a decoction, or approximately 500mg of standardized extract daily. The dried root can be simmered in water for 15-20 minutes to create a therapeutic tea. Dosage may vary depending on the specific condition being addressed and individual factors such as age and overall health status. Always follow the guidance of a qualified herbalist or healthcare practitioner for personalized dosing recommendations. Evidence Level: Traditional.

Is Korean Angelica Root safe to take during pregnancy?

Korean Angelica Root is not safe during pregnancy and should be avoided. In Korean Hanbang medicine, it is classified as a blood-moving herb, which means it stimulates blood circulation and uterine activity. This action can potentially cause uterine contractions and increase the risk of miscarriage or premature labor. Pregnant women should not use this herb in any form, including teas, extracts, or supplements. Women who are breastfeeding should also exercise caution and consult a healthcare provider before use. Evidence Level: Traditional/Contraindicated.

What are the traditional uses of Korean Angelica Root?

Korean Angelica Root (Angelica gigas) has been used for centuries in Korean Hanbang medicine primarily as a blood tonic and women's health herb. Traditional applications include treating menstrual disorders such as irregular periods and menstrual pain, supporting recovery after childbirth, and addressing joint pain and inflammation. The herb is valued for its ability to nourish and move blood throughout the body, making it particularly beneficial for conditions associated with blood stagnation. Modern research has explored its anti-inflammatory properties. Evidence Level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Angelica gigas Nakai (AGN) is a medicinal herb native to Korea and Far-East countries, utilized for its anti-inflammatory, neuroprotective, and anticancer properties [PMID:29215592, PMID:39286287].

Contexte

Angelica gigas Nakai, also known as Korean Dang-gui or Cham Dang Gui, is a crucial oriental medicinal herb primarily grown in Korea [PMID:29215592, PMID:39949365]. It is often distinguished from other species like A. sinensis and A. acutiloba through chemical profiling [PMID:37310353, PMID:35486828].

Usages traditionnels

Traditionally used in Southeast Asia and Korea to treat anemia, pain, infection, articular rheumatism, and blood-deficiency-related disorders [PMID:22583405, PMID:32983252]. It is also referred to as 'female ginseng' due to its role in treating gynecological problems [PMID:29215592]. Other traditional uses include as a sedative, tonic, and to promote blood flow [PMID:28452965, PMID:39286287].

Composés actifs

The root contains pyranocoumarins (specifically decursin, decursinol angelate, and decursinol), polyacetylenes, essential oils, and the furanocoumarin nodakenin [PMID:29215592, PMID:39779619, PMID:12877552].

Mécanisme d'action

Mechanisms include the activation of PI3K/AKT/mTOR and MAPK signaling pathways for neuroprotection [PMID:34062098], induction of ferroptosis via the NRF2/GPX4/SLC11A2 axis in hepatocellular carcinoma [PMID:41496356], and inhibition of melanogenesis via the ERK/MSK1 pathway [PMID:37138409]. It also modulates the AR/ERK signaling pathway for benign prostatic hyperplasia [PMID:41270388] and targets the inflammasome and neutrophil extracellular traps (NETs) in acute lung injury when used in the SH003 formula [PMID:39128302].

Preuves cliniques

Preuve BSkin wrinkles

A double-blinded clinical study demonstrated that A. gigas Nakai root extract (ARE) lotion significantly improved anti-wrinkle properties and increased type I collagen production by 40% in vitro [PMID:35460310]

Preuve CCancer

The multi-herbal formula SH003 (containing A. gigas) has shown potential as a chemotherapeutic agent in in vitro and in vivo studies, with a clinical trial performed to identify the maximum tolerated dose in solid cancer patients [PMID:35205836, PMID:40295067]

Preuve DIschemic Brain Injury

Methanol extracts of A. gigas root significantly reduced infarction volumes and morphological deterioration in mouse models of stroke [PMID:32983252, PMID:34062098]

Preuve DVascular Dysfunction

A. gigas extract restored diminished vascular relaxation responses to acetylcholine in high fat diet rats [PMID:38095615]

Sécurité et effets indésirables

The root is considered safe in humans [PMID:34062098].

Synthèse des preuves

The evidence is primarily based on in vitro and in vivo animal models (Level D) and narrative reviews (Level C), with limited clinical trial data (Level B) specifically for cosmetic applications.

Sources PubMed

1.PMID: 39128302 (2024) — The multi-herbal decoction SH003 alleviates LPS-induced acute lung injury by targeting inflammasome and extracellular traps in neutrophils. · Phytomedicine : international journal of phytotherapy and phytopharmacology
2.PMID: 39779619 (2025) — Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy - active Phytochemicals and In Vivo Molecular Targets. · Pharmaceutical research
3.PMID: 29215592 (2017) — Natural Korean Medicine Dang-Gui: Biosynthesis, Effective Extraction and Formulations of Major Active Pyranocoumarins, Their Molecular Action Mechanism in Cancer, and Other Biological Activities. · Molecules (Basel, Switzerland)
4.PMID: 28452965 (2017) — Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review. · Scientia pharmaceutica
5.PMID: 30652050

Korean Angelica Root

Sources et citations

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