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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Laburnum anagyroides
A European ornamental tree; all parts highly toxic; cytisine research for smoking cessation.
Cytisus laburnum (Laburnum anagyroides) is a highly toxic ornamental tree whose alkaloid cytisine has been repurposed as a partial agonist at nicotinic acetylcholine receptors for smoking cessation. Despite its historical use as an emetic and veterinary parasiticide, all parts of the plant are dangerous, and only purified pharmaceutical cytisine is used therapeutically.
Cytisine acts as a partial agonist at α4β2 nicotinic acetylcholine receptors (nAChRs) in the brain, reducing nicotine cravings and withdrawal symptoms by mimicking nicotine's effects with lower intrinsic efficacy. It also binds to other nAChR subtypes, contributing to its efficacy and side effect profile. The alkaloids sparteine and anagyrine are toxic and contribute to the plant's overall toxicity by blocking ganglionic nicotinic receptors and causing neuromuscular blockade.
A European ornamental tree; all parts highly toxic; cytisine research for smoking cessation.
Cytisus laburnum (Laburnum anagyroides) is a highly toxic ornamental tree whose alkaloid cytisine has been repurposed as a partial agonist at nicotinic acetylcholine receptors for smoking cessation. Despite its historical use as an emetic and veterinary parasiticide, all parts of the plant are dangerous, and only purified pharmaceutical cytisine is used therapeutically.
Cytisine acts as a partial agonist at α4β2 nicotinic acetylcholine receptors (nAChRs) in the brain, reducing nicotine cravings and withdrawal symptoms by mimicking nicotine's effects with lower intrinsic efficacy. It also binds to other nAChR subtypes, contributing to its efficacy and side effect profile. The alkaloids sparteine and anagyrine are toxic and contribute to the plant's overall toxicity by blocking ganglionic nicotinic receptors and causing neuromuscular blockade.