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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Lobelia inflata
North American herb used by Native Americans and Eclectic physicians; powerful respiratory antispasmodic.
Lobelia inflata (Indian tobacco) is a North American herb historically used by Native Americans and Eclectic physicians as a powerful respiratory antispasmodic. Its primary active compound, lobeline, acts as a partial agonist at nicotinic acetylcholine receptors, contributing to bronchodilation, expectoration, and potential smoking cessation effects. However, the plant also contains other alkaloids (lobelanine, lobelanidine) and has a narrow therapeutic index, with significant toxicity risks including nausea, vomiting, and respiratory depression.
Lobeline is a partial agonist at α4β2 and α3β4 nicotinic acetylcholine receptors (nAChRs), modulating neurotransmitter release (dopamine, norepinephrine) and respiratory drive. It also inhibits dopamine and norepinephrine reuptake, which may underlie its effects on addiction and mood. Additionally, lobeline exhibits antispasmodic activity on bronchial smooth muscle via calcium channel antagonism and possibly through muscarinic receptor interactions. The alkaloids lobelanine and lobelanidine stimulate gastric and respiratory reflexes, contributing to expectorant and emetic actions.
North American herb used by Native Americans and Eclectic physicians; powerful respiratory antispasmodic.
Lobelia inflata (Indian tobacco) is a North American herb historically used by Native Americans and Eclectic physicians as a powerful respiratory antispasmodic. Its primary active compound, lobeline, acts as a partial agonist at nicotinic acetylcholine receptors, contributing to bronchodilation, expectoration, and potential smoking cessation effects. However, the plant also contains other alkaloids (lobelanine, lobelanidine) and has a narrow therapeutic index, with significant toxicity risks including nausea, vomiting, and respiratory depression.
Lobeline is a partial agonist at α4β2 and α3β4 nicotinic acetylcholine receptors (nAChRs), modulating neurotransmitter release (dopamine, norepinephrine) and respiratory drive. It also inhibits dopamine and norepinephrine reuptake, which may underlie its effects on addiction and mood. Additionally, lobeline exhibits antispasmodic activity on bronchial smooth muscle via calcium channel antagonism and possibly through muscarinic receptor interactions. The alkaloids lobelanine and lobelanidine stimulate gastric and respiratory reflexes, contributing to expectorant and emetic actions.