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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Ludwigia octovalvis is an aquatic plant used in traditional medicine for conditions such as diabetes, hypertension, and wound management [PMID:28666833, 37447139, 39345301].
Contexte
Ludwigia octovalvis (also known as willow primrose) is a globally distributed wetland plant belonging to the Onagraceae family [PMID: 27856583, 28695387].
Usages traditionnels
Historically consumed as a healthful drink for treating edema, nephritis, hypotension, diabetes, dysentery, diarrhea, and headache [PMID: 28666833, 26091966, 22705121]. It is also used traditionally in parts of Asia for wound management [PMID: 39345301] and as a diuretic [PMID: 19963029].
Composés actifs
The plant contains oleanane-type triterpenes including (23Z)-feruloylhederagenin, (23E)-feruloylhederagenin, beta-amyrin acetate, and beta-amyrin palmitate [PMID: 17365192], as well as (23Z)-coumaroylhederagenin, (23E)-coumaroylhederagenin, (3Z)-coumaroylhederagenin, oleanolic acid, and ursolic acid [PMID: 14738395]. Other identified constituents include chlorophyll a [PMID: 19963029], polyphenols, flavonoids [PMID: 24338263], beta-sitosterol, 2alpha-hydroxy ursolic acid, tormentic acid, daucosterol, maltol, luteolin, quercetin, apigenin, methyl brevifolincarboxylate, gallic acid, and ellagic acid [PMID: 16494025].
Mécanisme d'action
Chlorophyll a from L. octovalvis activates the CD95 (APO-1/CD95) system and AMPK pathway in 3T3-L1 cells [PMID: 19963029]. Extracts may regulate lifespan through a dietary restriction (DR)-related pathway and activate AMPK [PMID: 24338263, 28666833]. The plant also contains compounds capable of inhibiting digestive enzymes, including alpha-amylase, alpha-glucosidase, lipase, and pepsin [PMID: 37835184, 30105075].
Preuves cliniques
Preuve DDiabetes/Hyperglycemia
Extracts improved glycemic control in streptozotocin-induced and high fat diet-induced diabetic mice [PMID: 28666833] and decreased fasting glycemia in a murine model of metabolic syndrome [PMID: 37447139].
Preuve DCognitive Decline/Memory
Extracts attenuated age-related memory deficits in Drosophila melanogaster and SAMP8 mice [PMID: 24338263, 28666833].
Preuve DMetabolic Syndrome/Obesity
Hydroalcoholic extract and ethyl acetate fraction significantly decreased body weight gain, systolic and diastolic blood pressure, and insulin resistance (TyG index) in hypercaloric diet mice [PMID: 37447139].
Preuve DExercise Performance
Oral administration in mice dose-dependently increased endurance swimming time and increased gastrocnemius muscle glycogen content [PMID: 29962382].
Preuve DWound Healing
Ethanolic extract was investigated for wound healing potential using an excision wound model in Sprague-Dawley rats [PMID: 39345301].
Preuve D
Sécurité et effets indésirables
In an acute toxicity study in BALB/c mice, a single oral dose of 5000 mg/kg showed no mortality or toxic symptoms over 14 days [PMID: 22705121]. Subacute toxicity (up to 800 mg/kg daily for 28 days) was also evaluated [PMID: 22705121].
Synthèse des preuves
The evidence is primarily based on in vitro studies and animal models (mice, rats, and Drosophila), indicating potential anti-hyperglycemic, anti-obesity, and neuroprotective effects. No human clinical trials were provided.
Sources PubMed
1.PMID: 17365192 (2007) — Oleanane-type triterpenes from Ludwigia octovalvis. · Journal of Asian natural products research
3.PMID: 28666833 (2017) — Ludwigia octovalvis extract improves glycemic control and memory performance in diabetic mice. · Journal of ethnopharmacology
4.PMID: 24338263 (2014) — The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice. · Age (Dordrecht, Netherlands)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Screening of Formosan plant drugs showed significant antihepatotoxic activity against cytotoxicity produced by carbon tetrachloride and D-galactosamine [PMID: 3586694].
Preuve DImmune Response
Methanolic extract significantly increased IgA serum levels in Balb/c mice following E. coli O157:H7 infection [PMID: 26091966].
— Chemical Characterization, Antilipidemic Effect and Anti-Obesity Activity of Ludwigia octovalvis in a Murine Model of Metabolic Syndrome.
· Plants (Basel, Switzerland)
6.PMID: 39345301 (2024) — Wound Healing and Acute Dermal Toxicity Studies of Ludwigia octovalvis (Jacq.) P. H. Raven (Onagraceae) in Sprague-Dawley Rats. · Journal of tropical medicine
7.PMID: 3586694 (1987) — Antihepatotoxic actions of Formosan plant drugs. · Journal of ethnopharmacology
8.PMID: 29962382 (2019) — Ludwigia octovalvis (Jacq.) raven extract supplementation enhances muscle glycogen content and endurance exercise performance in mice. · The Journal of veterinary medical science
9.PMID: 26091966 (2015) — Immune-stimulating properties of 80% methanolic extract of Ludwigia octovalvis against Shiga toxin-producing E. coli O157:H7 in Balb/c mice following experimental infection. · Journal of ethnopharmacology
10.PMID: 22705121 (2012) — Toxicological evaluation of 80% methanol extract of Ludwigia octovalvis (Jacq.) P.H. Raven leaves (Onagraceae) in BALB/c mice. · Journal of ethnopharmacology
11.PMID: 19963029 (2010) — Chlorophyll a, an active anti-proliferative compound of Ludwigia octovalvis, activates the CD95 (APO-1/CD95) system and AMPK pathway in 3T3-L1 cells. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
12.PMID: 30105075 (2018) — Identification of Digestive Enzyme Inhibitors from Ludwigia octovalvis (Jacq.) P.H.Raven. · Evidence-based complementary and alternative medicine : eCAM
13.PMID: 14738395 (2004) — Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. · Journal of natural products
14.PMID: 23082084 (2012) — In vitro screening of medicinal plants used in Mexico as antidiabetics with glucosidase and lipase inhibitory activities. · Evidence-based complementary and alternative medicine : eCAM
15.PMID: 27856583 (2016) — Complete Plastome Sequence of Ludwigia octovalvis (Onagraceae), a Globally Distributed Wetland Plant. · Genome announcements
16.PMID: 16494025 (2005) — [Studies on the chemical constituents in herb of Ludwigia octovalvis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica