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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Aristolochia contorta
A TCM herb historically used for lung heat cough - now rarely used due to aristolochic acid toxicity.
Ma Dou Ling (Aristolochia contorta) is a traditional Chinese herb historically used for lung heat cough, but its use is now severely restricted due to aristolochic acid (AA) content, which causes irreversible nephrotoxicity and urothelial carcinoma. Active compounds include aristolochic acid, magnoflorine, and allantoin. Despite anti-inflammatory and antitussive properties, its clinical use is limited to professional settings with extreme caution.
Aristolochic acid (AA) is metabolically activated by nitroreduction to form DNA adducts, leading to mutations in the TP53 gene and promoting urothelial carcinoma. AA also induces proximal tubular cell apoptosis via mitochondrial dysfunction and oxidative stress, resulting in chronic kidney disease. Magnoflorine exhibits anti-inflammatory effects through inhibition of NF-κB and COX-2 pathways, but these benefits are overshadowed by AA toxicity.
A TCM herb historically used for lung heat cough - now rarely used due to aristolochic acid toxicity.
Ma Dou Ling (Aristolochia contorta) is a traditional Chinese herb historically used for lung heat cough, but its use is now severely restricted due to aristolochic acid (AA) content, which causes irreversible nephrotoxicity and urothelial carcinoma. Active compounds include aristolochic acid, magnoflorine, and allantoin. Despite anti-inflammatory and antitussive properties, its clinical use is limited to professional settings with extreme caution.
Aristolochic acid (AA) is metabolically activated by nitroreduction to form DNA adducts, leading to mutations in the TP53 gene and promoting urothelial carcinoma. AA also induces proximal tubular cell apoptosis via mitochondrial dysfunction and oxidative stress, resulting in chronic kidney disease. Magnoflorine exhibits anti-inflammatory effects through inhibition of NF-κB and COX-2 pathways, but these benefits are overshadowed by AA toxicity.