Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Contexte
Usages traditionnels
Composés actifs
Mécanisme d'action
Preuves cliniques
Bark extracts and specific lignans ((+)-galbelgin and meso-dihydroguaiaretic acid) significantly inhibited TSLP/TSLPR interaction and STAT5 phosphorylation in human mast cells [PMID: 34443392]
Topical treatment in hairless mice decreased skin/epidermis thickness and MDA levels while increasing SOD levels [PMID: 20127882]
Lignans including isoguaiacin, meso-dihydroguaiaretic acid, licarin A, and (+)-guaiacin protected rat cortical cells against glutamate-induced neurotoxicity [PMID: 14765301]
(-)-Acuminatin, (-)-isoguaiacin, and meso-dihydroguaiaretic acid reduced glutamic pyruvic transaminase release and preserved glutathione, SOD, glutathione peroxidase, and catalase in CCl4-injured rat hepatocytes [PMID: 11045899]
Arylnaphthalene type lignans (guaiacin, isoguaiacin, and isoguaiacin dimethylether) increased alkaline phosphatase activity, collagen synthesis, and calcium deposition in mouse osteoblasts [PMID: 17409528]
Interactions médicamenteuses
Synthèse des preuves
Sources PubMed
- 1.PMID: 34443392 (2021) — Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors. · Molecules (Basel, Switzerland)
- 2.PMID: 37965621 (2023) — Dataset on the compounds from the leaves of Vietnamese Machilus thunbergii and their anti-inflammatory activity. · Data in brief
- 3.PMID: 35038992 (2022) — More opportunities more species: Pleistocene differentiation and northward expansion of an evergreen broad-leaved tree species Machilus thunbergii (Lauraceae) in Southeast China. · BMC plant biology
- 4.PMID: 20127882 (2010) — Effects of Machilus thunbergii Sieb et Zucc on UV-induced photoaging in hairless mice. · Phytotherapy research : PTR
- 5.PMID: 26055126 (2015)