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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Machilus thunbergii
Evergreen tree of coastal East Asia from Japan to China with large leaves, used in traditional Japanese and Chinese medicine.
Machilus thunbergii is an evergreen tree used in traditional Japanese Kampo and Chinese medicine for pain, inflammation, rheumatism, and skin conditions. Its bark and leaves contain lignans such as machilin and magnolenin, along with flavonoids and tannins, which contribute to its anti-inflammatory, analgesic, antimicrobial, and wound-healing properties. Evidence is limited to preclinical and traditional use, with no high-quality human trials available.
The anti-inflammatory effects are attributed to machilin and magnolenin, which inhibit cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), reducing prostaglandin and leukotriene synthesis. Flavonoids and tannins provide antioxidant activity by scavenging reactive oxygen species and chelating metal ions, while also modulating nuclear factor-kappa B (NF-κB) signaling. Antimicrobial action involves disruption of bacterial cell membranes and inhibition of biofilm formation, likely due to phenolic compounds. Analgesic effects may involve peripheral opioid receptors and transient receptor potential (TRP) channel modulation.
Evergreen tree of coastal East Asia from Japan to China with large leaves, used in traditional Japanese and Chinese medicine.
Machilus thunbergii is an evergreen tree used in traditional Japanese Kampo and Chinese medicine for pain, inflammation, rheumatism, and skin conditions. Its bark and leaves contain lignans such as machilin and magnolenin, along with flavonoids and tannins, which contribute to its anti-inflammatory, analgesic, antimicrobial, and wound-healing properties. Evidence is limited to preclinical and traditional use, with no high-quality human trials available.
The anti-inflammatory effects are attributed to machilin and magnolenin, which inhibit cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), reducing prostaglandin and leukotriene synthesis. Flavonoids and tannins provide antioxidant activity by scavenging reactive oxygen species and chelating metal ions, while also modulating nuclear factor-kappa B (NF-κB) signaling. Antimicrobial action involves disruption of bacterial cell membranes and inhibition of biofilm formation, likely due to phenolic compounds. Analgesic effects may involve peripheral opioid receptors and transient receptor potential (TRP) channel modulation.