Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Macrozamia communis
Australian cycad whose seeds were traditionally processed and eaten by Aboriginal peoples.
Macrozamia communis is an Australian cycad historically used as a starch food source by Aboriginal peoples after extensive detoxification, but it contains potent neurotoxins and hepatotoxins including cycasin, macrozamin, and BMAA. Its primary modern relevance is as a cautionary example of traditional processing to remove toxicity, with no safe medicinal applications in raw form.
The primary neurotoxic mechanism involves beta-methylamino-L-alanine (BMAA), a non-protein amino acid that can be misincorporated into proteins, leading to protein misfolding and neurodegeneration. Cycasin and macrozamin are glycosides that are metabolized to methylazoxymethanol (MAM), a potent alkylating agent causing DNA damage and hepatotoxicity. These compounds also inhibit glutamate transport and induce excitotoxicity via NMDA receptor overactivation.
Australian cycad whose seeds were traditionally processed and eaten by Aboriginal peoples.
Macrozamia communis is an Australian cycad historically used as a starch food source by Aboriginal peoples after extensive detoxification, but it contains potent neurotoxins and hepatotoxins including cycasin, macrozamin, and BMAA. Its primary modern relevance is as a cautionary example of traditional processing to remove toxicity, with no safe medicinal applications in raw form.
The primary neurotoxic mechanism involves beta-methylamino-L-alanine (BMAA), a non-protein amino acid that can be misincorporated into proteins, leading to protein misfolding and neurodegeneration. Cycasin and macrozamin are glycosides that are metabolized to methylazoxymethanol (MAM), a potent alkylating agent causing DNA damage and hepatotoxicity. These compounds also inhibit glutamate transport and induce excitotoxicity via NMDA receptor overactivation.