Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Phaleria macrocarpa
Indonesian medicinal tree from Papua whose fruit is used for diabetes, hypertension, and liver disease.
Mahkota Dewa (Phaleria macrocarpa) is a medicinal tree from Papua, Indonesia, traditionally used in Javanese royal medicine for diabetes, hypertension, and liver disease. Its fruit contains flavonoids such as kaempferol, quercetin, and myricetin, along with gallic acid and alkaloids, which contribute to its antidiabetic, antihypertensive, and hepatoprotective properties. Modern research suggests potential anticancer activity, though evidence remains limited (Level C).
The antidiabetic effects are attributed to flavonoid-induced activation of AMPK and PPARγ pathways, enhancing insulin sensitivity and glucose uptake. The antihypertensive action may involve inhibition of angiotensin-converting enzyme (ACE) and calcium channel blockade by gallic acid and quercetin. Hepatoprotective effects are mediated through antioxidant activity and suppression of pro-inflammatory cytokines via NF-κB inhibition. Additionally, alkaloids and flavonoids exhibit cytotoxic effects on cancer cells through induction of apoptosis and cell cycle arrest.
Indonesian medicinal tree from Papua whose fruit is used for diabetes, hypertension, and liver disease.
Mahkota Dewa (Phaleria macrocarpa) is a medicinal tree from Papua, Indonesia, traditionally used in Javanese royal medicine for diabetes, hypertension, and liver disease. Its fruit contains flavonoids such as kaempferol, quercetin, and myricetin, along with gallic acid and alkaloids, which contribute to its antidiabetic, antihypertensive, and hepatoprotective properties. Modern research suggests potential anticancer activity, though evidence remains limited (Level C).
The antidiabetic effects are attributed to flavonoid-induced activation of AMPK and PPARγ pathways, enhancing insulin sensitivity and glucose uptake. The antihypertensive action may involve inhibition of angiotensin-converting enzyme (ACE) and calcium channel blockade by gallic acid and quercetin. Hepatoprotective effects are mediated through antioxidant activity and suppression of pro-inflammatory cytokines via NF-κB inhibition. Additionally, alkaloids and flavonoids exhibit cytotoxic effects on cancer cells through induction of apoptosis and cell cycle arrest.