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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Mandragora officinarum
Mythical and toxic Mediterranean plant of ancient medicine used as a powerful sedative, aphrodisiac, and surgical anesthetic.
Mandragora officinarum (mandrake) is a highly toxic Mediterranean plant historically used as a surgical anesthetic, sedative, and aphrodisiac in ancient and folk medicine. Its primary active compounds are the tropane alkaloids scopolamine, hyoscyamine, and atropine, which exert potent anticholinergic effects. Modern evidence is limited to case reports and pharmacological studies, confirming its anticholinergic and sedative properties but also its narrow therapeutic index and severe toxicity.
The tropane alkaloids in Mandragora officinarum act as competitive antagonists at muscarinic acetylcholine receptors (M1–M5), blocking parasympathetic neurotransmission. This leads to anticholinergic effects including sedation, amnesia, mydriasis, tachycardia, and inhibition of secretions. Scopolamine is particularly active in the central nervous system, producing delirium and hallucinations at higher doses. The plant also contains cuscohygrine, a pyrrolidine alkaloid with weak anticholinergic activity.
Mythical and toxic Mediterranean plant of ancient medicine used as a powerful sedative, aphrodisiac, and surgical anesthetic.
Mandragora officinarum (mandrake) is a highly toxic Mediterranean plant historically used as a surgical anesthetic, sedative, and aphrodisiac in ancient and folk medicine. Its primary active compounds are the tropane alkaloids scopolamine, hyoscyamine, and atropine, which exert potent anticholinergic effects. Modern evidence is limited to case reports and pharmacological studies, confirming its anticholinergic and sedative properties but also its narrow therapeutic index and severe toxicity.
The tropane alkaloids in Mandragora officinarum act as competitive antagonists at muscarinic acetylcholine receptors (M1–M5), blocking parasympathetic neurotransmission. This leads to anticholinergic effects including sedation, amnesia, mydriasis, tachycardia, and inhibition of secretions. Scopolamine is particularly active in the central nervous system, producing delirium and hallucinations at higher doses. The plant also contains cuscohygrine, a pyrrolidine alkaloid with weak anticholinergic activity.