Mangifera indica (Mangifera indica): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Mangifera indica work to lower blood sugar?

Mangifera indica contains bioactive compounds, particularly mangiferin, that exert antidiabetic effects through multiple mechanisms. Mangiferin enhances glucose uptake in peripheral tissues, inhibits intestinal glucose absorption, and protects pancreatic beta-cells from oxidative damage. The flavonoids quercetin and kaempferol provide additional antioxidant activity that may improve insulin sensitivity. These compounds also modulate key enzymes involved in carbohydrate metabolism. Evidence Level: C (preclinical studies support these mechanisms, though human trials remain limited).

Can mango leaf extract interact with diabetes medications?

Yes, Mangifera indica may interact with blood sugar-lowering medications. Because mango leaf extract and mangiferin can reduce blood glucose levels, taking them alongside antidiabetic drugs like metformin or insulin may cause additive effects, potentially leading to hypoglycemia. Patients with diabetes should monitor blood glucose closely and consult a healthcare provider before combining mango preparations with prescribed diabetes medications. Dosage adjustments may be necessary. Evidence Level: C.

What is the recommended dosage for mango leaf extract?

Traditional and clinical use suggests 500mg of standardized mangiferin extract daily for therapeutic purposes. Alternatively, 5-10 grams of dried mango leaves can be prepared as an infusion or tea, consumed 1-2 times daily. Standardized extracts ensure consistent mangiferin content, which is the primary active compound. Dosage may vary based on the specific preparation and intended use. Consult a qualified healthcare practitioner for personalized recommendations. Evidence Level: C/Traditional.

Is mango leaf tea safe during pregnancy?

Mango fruit and leaves are generally considered safe during pregnancy when consumed in food amounts. Traditional use across Asia and Africa has not identified significant concerns for pregnant women. However, concentrated extracts and therapeutic doses of mangiferin have limited safety data in pregnancy. Pregnant women should stick to moderate dietary consumption and consult healthcare providers before using medicinal preparations. The fruit itself provides nutritional benefits including vitamins A and C. Evidence Level: C/Traditional.

What are the medicinal uses of mango leaves?

Mango leaves have been used traditionally across Asia and Africa for managing diabetes, digestive disorders, skin conditions, fever, and diarrhea. The leaves contain mangiferin, quercetin, kaempferol, and gallic acid, which contribute to anti-inflammatory, antioxidant, and antimicrobial properties. Modern research supports potential benefits for blood sugar regulation and gastrointestinal health. Preparations include teas, decoctions, and standardized extracts. Evidence Level: C (preclinical and preliminary clinical evidence supports traditional uses).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Mangifera indica (mango) is a tropical fruit tree known for its high nutritional value and diverse pharmacological properties, including antidiabetic and antioxidant effects [PMID:33467139, PMID:22228940].

Contexte

Mangifera indica L., belonging to the Anacardiaceae family, is a long-living evergreen plant cultivated for thousands of years, primarily in the tropics and subtropics of Asia, Africa, and Central and South America [PMID:32506936, PMID:37653856, PMID:42104244].

Usages traditionnels

The plant is commonly used in ayurvedic medicine [PMID:22228940]. Dried mango tree leaves have been traditionally used to treat diabetes and respiratory infections [PMID:31257318].

Composés actifs

Bioactive compounds include polyphenols (such as mangiferin, gallotannins, and gallic acid), terpenoids, carotenoids, phytosterols, vitamins A and C, and essential amino acids [PMID:32506936, PMID:34324201, PMID:34066494]. Mangiferin is a major bioactive xanthone found primarily in the mango tree [PMID:36656353].

Mécanisme d'action

Mangiferin may regulate lipid metabolism by being converted to its active metabolite, northyariol, which activates sirtuin-1 and liver kinase B1, increasing intracellular AMP levels and AMP-activated protein kinase phosphorylation [PMID:31257318]. Mango polyphenols can modulate intestinal microbiota, such as Lactobacillus plantarum, to provide prebiotic effects and lower intestinal inflammation [PMID:34066494].

Preuves cliniques

Preuve AType 2 Diabetes Mellitus

Evidence from animal and human studies supports the glucose-lowering properties of various mango plant parts, including leaves, flesh, seed-kernel, and peel [PMID:36841190].

Preuve ACardio-metabolic health

Utilization of mango in various forms (fresh slices, puree, leaf extract, fruit powder, and mangiferin) yielded improvements in glycemic control and plasma lipid profiles [PMID:38137871].

Preuve ADental Caries

A systematic review of 3 randomized controlled trials involving 130 people (mostly children) evaluated the effect of Mangifera indica on dental caries [PMID:38024868].

Interactions médicamenteuses

Mango polyphenols have some potential to interact with intestinal enzymes or transporter systems, though interaction with hepatic enzymes is considered less likely [PMID:34066494].

Synthèse des preuves

The evidence consists largely of systematic reviews and laboratory/animal studies (Levels A and C), with limited clinical trial data specifically for dental caries and metabolic syndrome.

Sources PubMed

1.PMID: 33467139 (2021) — Nutritional Composition and Bioactive Compounds in Three Different Parts of Mango Fruit. · International journal of environmental research and public health
2.PMID: 22228940 (2010) — Mangifera indica (mango). · Pharmacognosy reviews
3.PMID: 38024868 (2023) — Effect of Mangifera Indica (Mango) on Dental Caries: A Systematic Review. · Nutrition and metabolic insights
4.PMID: 34833457 (2021) — Contact Allergy Induced by Mango (Mangifera indica): A Relevant Topic? · Medicina (Kaunas, Lithuania)
5.PMID: 37653856 (2023) — Molecular Insights into Abiotic Stresses in Mango. · Plants (Basel, Switzerland)
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Mangifera indica

Sources et citations

Calculer une dose sûre de Mangifera indica