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M
Not CommonVérifié
Marjolaine
Origanum majorana
Troubles digestifs en médecine européenne et unani
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Origanum majorana, known as sweet marjoram, is an aromatic medicinal plant from the Lamiaceae family used traditionally for various disorders and recognized for its wide range of pharmacological activities [PMID:27231340, PMID:36556347].
Contexte
Origanum majorana L. is an aromatic and medicinal plant distributed across Mediterranean countries, widely used both as a seasoning ingredient and for therapeutic purposes [PMID:32882360, PMID:34631774].
Usages traditionnels
Traditional and folklore medicine uses include the treatment of gastrointestinal, ocular, nasopharyngeal, respiratory, cardiac, rheumatologic, and neurological disorders [PMID:27231340], as well as allergies, hypertension, diabetes, stomach pain, and intestinal antispasmodic needs [PMID:32882360]. It is also locally reputed for regulating the menstrual cycle and restoring hormonal balance [PMID:25662759].
Composés actifs
Chemical constituents include essential oils containing monoterpene hydrocarbons, oxygenated monoterpenes (such as terpinen-4-ol, alpha-terpineol, and gamma-terpinene), and phenolic compounds [PMID:27231340, PMID:38420828, PMID:36144869, PMID:39537771]. Specific identified compounds include arbutin, apigenin 7-O-glucoside, rosmarinic acid, salvianolic acid B, and procumboside B [PMID:40457736, PMID:42123895, PMID:34631774].
Mécanisme d'action
Marjoram may induce vasorelaxation via the PI3-K/eNOS/cGMP pathway [PMID:31212721]. Its antidiarrheal and antispasmodic effects are associated with calcium channel inhibitory activity [PMID:38420828]. Antifungal activity is attributed to ergosterol complexation [PMID:31621419]. In cancer cells, it may decrease viability via induction of caspase 3/7-dependent cell death and downregulation of survivin [PMID:36182733].
Preuves cliniques
Preuve BPolycystic Ovary Syndrome (PCOS)
Marjoram tea significantly reduced DHEA-S and fasting insulin levels [PMID:25662759]
Preuve BParkinson's Disease
Consumption of Origanum majorana tea significantly increased superoxide dismutase (SOD) levels, indicating an effect on oxidative stress biomarkers [PMID:41052623]
Preuve DDiarrhea
Methanolic extract showed substantial inhibitory effect on diarrheal episodes in mice, with 80% protection at 400 mg/kg [PMID:38420828]
Preuve DNon-small cell lung cancer (NSCLC)
Essential oil significantly decreased cell viability in vitro and slowed tumor xenograft growth and metastasis in vivo [PMID:36182733]
Preuve DCutaneous sporotrichosis
Oral treatment with essential oil led to remission of cutaneous lesions and decreased fungal burden in systemic organs in rats [PMID:31621419]
Sécurité et effets indésirables
While data specifically for O. majorana is limited in the provided text, related Origanum species are generally recognized as safe (GRAS) as food ingredients, though rare reports of gastrointestinal upset and allergic skin reactions exist [PMID:30000904].
Synthèse des preuves
The evidence consists primarily of in vitro and in vivo animal studies (Level D) and small-scale randomized controlled pilot studies (Level B) in humans. There is strong preclinical evidence for antimicrobial, antioxidant, and antispasmodic activities, but limited large-scale clinical data.
2.PMID: 27231340 (2017) — Sweet Marjoram: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities. · Journal of evidence-based complementary & alternative medicine
3.PMID: 36556347 (2022) — Origanum majorana Essential Oil-A Review of Its Chemical Profile and Pesticide Activity. · Life (Basel, Switzerland)
4.PMID: 32882360 (2021) — Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L. · Journal of ethnopharmacology
5.PMID: 40457736 (2025) — Phenolic compounds from Origanum majorana with biofilm-inhibitory activity against methicillin-resistant Staphylococcus aureus and Escherichia coli strains.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 38420828 (2024) — Calcium Channel Inhibitory Effect of Marjoram (Origanum majorana L.): Its Medicinal Use in Diarrhea and Gut Hyperactivity. · Frontiers in bioscience (Landmark edition)
7.PMID: 34631774 (2021) — Origanum majorana L.: A Nutritional Supplement With Immunomodulatory Effects. · Frontiers in nutrition
8.PMID: 31212721 (2019) — Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway. · Biomolecules
9.PMID: 42123895 (2026) — Polyphenol Diversity and Chemotype Variation in Origanum majorana and Related Species: Implications for Chemotaxonomic Differentiation, Standardisation and Genotype Selection. · Molecules (Basel, Switzerland)
10.PMID: 25662759 (2016) — The effect of marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome: a randomised controlled pilot study. · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
11.PMID: 36144869 (2022) — Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal. · Molecules (Basel, Switzerland)
12.PMID: 36182733 (2022) — Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
13.PMID: 31621419 (2021) — In vivo protection of the marjoram (Origanum majorana Linn.) essential oil in the cutaneous sporotrichosis by Sporothrix brasiliensis. · Natural product research
14.PMID: 41052623 (2025) — Effect of Origanum majorana tea on oxidative stress biomarkers in Parkinson's disease: a randomized placebo-controlled pilot study. · Neuroscience
15.PMID: 39537771 (2024) — Comparative volatiles profiling of two marjoram products via GC-MS analysis in relation to the antioxidant and antibacterial effects. · Scientific reports