Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Contexte
Usages traditionnels
Composés actifs
Mécanisme d'action
Preuves cliniques
Oral administration of M. germanica L. leaf extract (50-200 mg/kg) in streptozotocin-induced diabetic mice significantly decreased serum glucose, oxidative stress, and lipid peroxidation [PMID:29301240].
Aqueous-methanolic extracts of leaves showed activity against Staphylococcus aureus, and stem bark was active against Enterococcus faecalis [PMID:41515347]. A compound extract of medlar and hawthorn was moderately sensitive to S. aureus and significantly inhibited Klebsiella pneumoniae [PMID:24146490].
Leaf flavone extract showed strong cytotoxicity on the HepG2 cell line, and leaf bound phenolic acids demonstrated strong cytotoxicity on the HeLa cell line [PMID:37395516].
Synthèse des preuves
Sources PubMed
- 1.PMID: 38586220 (2024) — Phytochemistry, nutritional composition, health benefits and future prospects of Mespilus germanica L. (Medlar): A review. · Food chemistry: X
- 2.PMID: 37628075 (2023) — Changes in the Fruit Quality Parameters of Medlar Fruit (Mespilus germanica L.) after Heat Treatment, Storage, Freezing or Hoarfrost. · Foods (Basel, Switzerland)
- 3.PMID: 41976516 (2026) — Underutilized Medlar (Mespilus germanica L.) Fruit as a Source of Dietary Fibers. · Foods (Basel, Switzerland)
- 4.PMID: 38850406 (2024) — Phenolic Contents, Antioxidant Activities, LCMS Profiles of Mespilus germanica Leaf Extract and Effects on mRNA Transcription Levels of Apoptotic, Autophagic, and Necrotic Genes in MCF7 and A549 Cancer Cell Lines. · Cell biochemistry and biophysics
- 5.PMID: 29301240