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PubMed · Tagetes lucida Cav. essential oil and the mixture of its main compounds are antibacterial and modulate antibiotic resistance in multi-resistant pathogenic bacteria. (2022)
PubMed · Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties. (2016)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Tagetes lucida, also known as Mexican marigold, yauhtli, or pericón, is a medicinal plant native to America used primarily in traditional Mexican medicine for central nervous system and inflammatory disorders [PMID:30388858, 32961278, 36365258].
Contexte
Tagetes lucida (Mexican marigold) is a species of the Tagetes genus native to America [PMID:30388858]. It is widely utilized in folk medicine, particularly in Mexico, to treat various health problems including those related to the central nervous system, inflammation, and gastrointestinal issues [PMID:30388858, 34789033, 36365258].
Usages traditionnels
In traditional Mexican medicine, it is used to treat anxiety, depressant diseases, pain, hypertension, and disorders associated with inflammation [PMID:32961278, 34789033]. It is also used as a remedy for gastrointestinal disorders causing stomachaches, abdominal cramps, and diarrhea [PMID:33193797].
Composés actifs
Bioactive compounds include coumarins (such as herniarin, scoparone, dimethylfraxetin, 7-O-prenylscopoletin, 7-O-prenylumbelliferone, and umbelliferone) [PMID:30618303, 36365258, 33193797], flavonoids (quercetagetin, quercetin, and rutin) [PMID:19127719, 34789033], terpenes (including $\beta$-caryophyllene) [PMID:32033302], and essential oil components such as estragole, methyl eugenol, linalool, and geraniol [PMID:35419861, 35807645]. It also contains thiophenes, specifically 5-(3-buten-1-ynyl)-2,2'-bithienyl [PMID:20394003], and phenolic acids like gallic, chlorogenic, quinic, and shikimic acids [PMID:37446829].
Mécanisme d'action
Antidepressant-like effects are mediated by 5-HT(1A) and 5-HT(2A) receptors [PMID:26062718]. Some constituents act as monoamine oxidase A (MAO-A) inhibitors [PMID:37446829]. Antihypertensive effects involve vasorelaxant activity on aortic rings [PMID:32961278]. Antispasmodic activity has been observed in guinea pig ileum segments [PMID:33193797].
Preuves cliniques
Preuve DDepression
Aqueous extracts showed antidepressant-like effects in rat forced swimming tests, reducing immobility and increasing swimming [PMID:18782612, 22809029, 26062718].
Preuve DInflammation/Pain
Coumarins and aqueous extracts demonstrated anti-inflammatory and antinociceptive effects in mice and rat models of auricular oedema and gout-pain [PMID:30618303, 34789033, 41067319].
Preuve DHypertension
Ethanolic extract lowered systolic and diastolic blood pressure in SHR rats without modifying heart rate [PMID:32961278].
Preuve DGastrointestinal Disorders
Aqueous extract showed antispasmodic activity in guinea pig ileum and antidiarrheal activity in the charcoal meal test in mice [PMID:33193797].
Preuve DBacterial Infection
Essential oil and its main compounds exhibited antibacterial activity and modulated antibiotic resistance in S. aureus and P. aeruginosa [PMID:35419861].
Preuve D
Sécurité et effets indésirables
Acute toxicity of the aqueous extract was evaluated using OECD guideline 425 in mice [PMID:41067319]. No specific adverse effects were reported in the provided abstracts, though one study noted no adverse effects on male sexual behavior in rats [PMID:18782612].
Interactions médicamenteuses
Extracts and isolated coumarins (herniarin and dimethylfraxetin) from T. lucida were found to increase the cataleptic effect of haloperidol in mice [PMID:36297813].
Synthèse des preuves
The evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential antidepressant, anti-inflammatory, antihypertensive, and antibacterial properties. No human clinical trials were provided in the abstracts.
Sources PubMed
1.PMID: 30388858 (2018) — Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity. · Molecules (Basel, Switzerland)
2.PMID: 34789033 (2022) — Isolation, chemical characterization, and anti-inflammatory activity of coumarins, flavonoids, and terpenes from Tagetes lucida. · Natural product research
3.PMID: 36297813 (2022) — Herniarin, Dimethylfraxetin and Extracts from Tagetes lucida, in Psychosis Secondary to Ketamine and Its Interaction with Haloperidol. · Plants (Basel, Switzerland)
4.PMID: 32961278 (2021) — Antihypertensive and vasorelaxant mode of action of the ethanol-soluble extract from Tagetes lucida Cav. aerial parts and its main bioactive metabolites. · Journal of ethnopharmacology
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Root ethanol extract showed hepatoprotective effects in CCl4-induced hepatotoxicity in rats by ameliorating oxidative stress [PMID:34347571].
(2020)
— Anti-inflammatory activity of coumarins isolated from Tagetes lucida Cav.
· Natural product research
6.PMID: 26062718 (2015) — Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. · Journal of natural medicines
7.PMID: 36365258 (2022) — Pharmacokinetics and Tissue Distribution of Coumarins from Tagetes lucida in an LPS-Induced Neuroinflammation Model. · Plants (Basel, Switzerland)
8.PMID: 32033302 (2020) — Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil. · Molecules (Basel, Switzerland)
9.PMID: 35419861 (2022) — Tagetes lucida Cav. essential oil and the mixture of its main compounds are antibacterial and modulate antibiotic resistance in multi-resistant pathogenic bacteria. · Letters in applied microbiology
10.PMID: 41067319 (2026) — Antinociceptive effect of Tagetes lucida in an arthritic gout-pain model in rats. · Journal of ethnopharmacology
11.PMID: 22809029 (2012) — Antidepressant-like effect of Tagetes lucida Cav. extract in rats: involvement of the serotonergic system. · The American journal of Chinese medicine
12.PMID: 19127719 (2006) — Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). · Journal of agricultural and food chemistry
13.PMID: 33193797 (2020) — Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action. · Evidence-based complementary and alternative medicine : eCAM
14.PMID: 37446829 (2023) — Analysis of Antioxidant Constituents of Filtering Infusions from Oak (Quercus sideroxyla Bonpl. and Quercus eduardii Trel.) and Yerbaniz (Tagetes lucida (Sweet) Voss) as Monoamine Oxidase Inhibitors. · Molecules (Basel, Switzerland)
15.PMID: 18782612 (2008) — Antidepressant-like effects of Tagetes lucida Cav. in the forced swimming test. · Journal of ethnopharmacology
16.PMID: 34347571 (2021) — Hepatoprotective effects of Tagetes lucida root extract in carbon tetrachloride-induced hepatotoxicity in Wistar albino rats through amelioration of oxidative stress. · Pharmaceutical biology
17.PMID: 35807645 (2022) — Photoprotective Agents Obtained from Aromatic Plants Grown in Colombia: Total Phenolic Content, Antioxidant Activity, and Assessment of Cytotoxic Potential in Cancer Cell Lines of Cymbopogon flexuosus L. and Tagetes lucida Cav. Essential Oils. · Plants (Basel, Switzerland)
18.PMID: 20394003 (2010) — Thiophene occurrence in different Tagetes species: agricultural biomasses as sources of biocidal substances. · Journal of the science of food and agriculture