Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
MW
Not CommonRésumée par IA
Mondia whitei
Mondia whitei
Aphrodisiaque masculin en médecine africaine de l'Est
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Mondia whitei is an aromatic medicinal plant native to sub-Saharan Africa, primarily recognized for its traditional use as an aphrodisiac and antidepressant [PMID:23039023, PMID:39002656].
Contexte
Mondia whitei, also known as African ginger or mondia, is an aromatic plant native to sub-Saharan Africa [PMID:23039023, PMID:39002656]. It is considered an important endangered medicinal and commercial plant in South Africa [PMID:27752244].
Usages traditionnels
Traditional uses in Africa include treatment for libido enhancement, appetite improvement, antidepressant properties, and as a galactagogue to stimulate milk production in lactating mothers [PMID:23039023, PMID:20161964]. It is also used to treat hypertension, diabetes, erectile dysfunction, premature ejaculation, pain, and fever [PMID:39002656, PMID:28480400].
Composés actifs
The plant contains reducing sugars, triterpenes, steroids, alkaloids, saponins, tannins, phenolics, hydrogen cyanide, carotenoids, and oxalates [PMID:39002656]. Specific identified compounds include the chlorinated coumarinolignan 5-chloropropacin [PMID:15771890], as well as rutin, quercetin, and kaempferol in fruit extracts [PMID:41970634].
Mécanisme d'action
In rabbits, Mondia whitei crude extract increased nitric oxide synthase (NOS) activity, leading to increased levels of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) [PMID:21461152]. In vitro studies suggest it may inhibit acetylcholinesterase (AChE) [PMID:27752244, PMID:38651748] and inhibit mitochondrial permeability transition (mPT) pores [PMID:30386748].
Preuves cliniques
Preuve DSexual Function (Animal Models)
Extracts significantly improved intromission, ejaculation, and erection in sexually inexperienced male rats [PMID:20162070].
Preuve DSperm Motility (In Vitro)
Aqueous extract significantly enhanced total and progressive motility of human spermatozoa in a time-dependent manner [PMID:18570264].
Preuve DSpermatogenesis (Animal Models)
Chronic administration (400 mg/kg/day for 55 days) in rats caused reversible cessation of spermatogenesis and partial antifertility effects [PMID:11180518].
Preuve DAntibacterial Activity (In Vitro)
Ethanolic extract showed activity against Streptococcus mutans [PMID:39381078].
Sécurité et effets indésirables
The plant is reasonably expected to be safe when prepared and used according to traditional practices [PMID:23039023]. However, chronic high-dose administration in rats (400 mg/kg/day for 55 days) resulted in testicular lesions and reversible antifertility effects [PMID:11180518]. Analysis of herbs marketed in Malawi showed Mondia whitei contained the highest mean cobalt (Co) concentrations among the studied herbs [PMID:37538931].
Grossesse et allaitement
Used traditionally as a galactagogue to stimulate milk production in lactating mothers [PMID:20161964].
Synthèse des preuves
The current evidence is primarily based on in vitro studies, animal models (rats, rabbits, mice), and literature reviews. There is a lack of human clinical trials to validate traditional claims.
Sources PubMed
1.PMID: 23039023 (2012) — Mondia whitei, a medicinal plant from Africa with aphrodisiac and antidepressant properties: a review. · Journal of dietary supplements
2.PMID: 39002656 (2024) — Ethnomedicinal, phytochemical, pharmacological and toxicological profile of Mondia whitei: A review. · Fitoterapia
3.PMID: 39381078 (2024) — A Preliminary Evaluation of the Antibacterial Activity of Lemon Fruit Juice, Mondia whitei Ethanolic Extract, and Their Combination Against Streptococcus mutans. · Infection and drug resistance
4.PMID: 30386748 (2018) — Mondia whitei, an African Spice Inhibits Mitochondrial Permeability Transition in Rat Liver. · Preventive nutrition and food science
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Effects of the aqueous and hexane extracts of Mondia whitei on the sexual behaviour and some fertility parameters of sexually inexperienced male rats.
· African journal of traditional, complementary, and alternative medicines : AJTCAM
6.PMID: 18570264 (2008) — The in vitro effects of Mondia whitei on human sperm motility parameters. · Phytotherapy research : PTR
7.PMID: 37538931 (2023) — Health risk assessment of toxic metal(loids) (As, Cd, Pb, Cr, and Co) via consumption of medicinal herbs marketed in Malawi. · Toxicology reports
8.PMID: 38651748 (2025) — Phytochemical analysis and antioxidant potential of Mondia whitei and Guibourtia tessmannii against H2O2-induced cytotoxicity in PC3 cells. · Journal of biomolecular structure & dynamics
9.PMID: 20161964 (2008) — Market survey of Mondia whytei (mulondo) roots in Kampala City, Uganda. · African journal of traditional, complementary, and alternative medicines : AJTCAM
10.PMID: 28480400 (2017) — ISOLATION OF NOVEL PARA-PENTYL PHENYL BENZOATE FROM MONDIA WHITEI. (HOOK.F.) SKEELS (PERIPLOCACEAE), ITS STRUCTURE, SYNTHESIS AND NEUROPHARMACOLOGICAL EVALUATION. · African journal of traditional, complementary, and alternative medicines : AJTCAM
11.PMID: 15771890 (2005) — A chlorinated coumarinolignan from the African medicinal plant, Mondia whitei. · Phytochemistry
12.PMID: 41970634 (2026) — In silico docking and in vivo assessment of Mondia whitei fruit extract in attenuating CdCl2-Induced neurodegeneration in rat. · Biochemistry and biophysics reports
13.PMID: 11180518 (2001) — Reversible antispermatogenic and antifertility activities of Mondia whitei L. in male albino rat. · Phytotherapy research : PTR
14.PMID: 27752244 (2016) — Acetylcholinesterase-Inhibition and Antibacterial Activity of Mondia whitei Adventitious Roots and Ex vitro-Grown Somatic Embryogenic-Biomass. · Frontiers in pharmacology
15.PMID: 21461152 (2010) — Modulation of penile erection in rabbits by Mondia whitei: possible mechanism of action. · African journal of traditional, complementary, and alternative medicines : AJTCAM