How does Morinda officinalis work for joint health?

Morinda officinalis contains active compounds including morindaparvin, morindin, morindone, anthraquinones, and iridoid glycosides that contribute to its anti-arthritic properties. These compounds are believed to modulate inflammatory pathways and support joint tissue health. In traditional Malaysian medicine, the root is prepared as a decoction to address joint discomfort. The evidence level for these mechanisms is rated C, indicating limited but promising preclinical research. Traditional use across Southeast Asia supports its application for musculoskeletal conditions.

Does Morinda officinalis interact with any medications?

Morinda officinalis may interact with medications metabolized by the liver due to its anthraquinone content. Patients taking anticoagulants, antiplatelet drugs, or hormone therapies should exercise caution, as the herb may affect drug metabolism. Those with prostate conditions should avoid this herb entirely. Always consult a qualified healthcare provider before combining Morinda officinalis with prescription medications, particularly blood thinners or hormone-related treatments.

What is the recommended dosage for Morinda officinalis?

The typical adult dosage for Morinda officinalis is 5-15 grams of dried root prepared as a decoction daily, or approximately 500mg of standardized extract. Traditional preparations involve simmering the root in water for 15-20 minutes. Dosage should be adjusted based on individual tolerance and the specific condition being addressed. Start with lower doses to assess tolerance, as higher doses may cause gastrointestinal upset. Consult a qualified herbalist for personalized dosing recommendations.

Is Morinda officinalis safe during pregnancy?

Morinda officinalis is considered unsafe during pregnancy and should be strictly avoided. The herb contains anthraquinones and other compounds that may stimulate uterine contractions or affect fetal development. Traditional contraindications explicitly list pregnancy as a condition where this herb should not be used. Women who are pregnant, attempting to conceive, or breastfeeding should not use Morinda officinalis in any form. Always consult a healthcare provider before using any herbal supplement during pregnancy.

What is Morinda officinalis used for in traditional medicine?

Morinda officinalis has been used traditionally across Southeast Asia for joint and reproductive health. In Malaysian traditional medicine, it is valued as a joint herb for addressing arthritis and musculoskeletal discomfort. Vietnamese folk medicine employs it as a reproductive tonic, particularly for male reproductive health. Philippine traditional practices also incorporate this herb for similar purposes. The evidence level for these traditional uses is rated C, indicating limited clinical research but established ethnobotanical documentation supporting its applications.

Morinda Officinalis (Morinda officinalis (var.))

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Morinda officinalis is a traditional Chinese medicinal herb used for tonifying the kidney and treating inflammatory, neurodegenerative, and bone-related conditions [PMID:29126988, PMID:36158563].

Contexte

Morinda officinalis (also known as Ba-Ji-Tian) is a medicinal and edible herb belonging to the Rubiaceae family, widely consumed as a functional food and used in traditional medicines in China and northeast Asia [PMID:38382668, PMID:38521432, PMID:29126988].

Usages traditionnels

It has been used traditionally as a tonic for nourishing the kidney, strengthening the bone, and enhancing immunofunction, specifically in the treatment of impotence, osteoporosis, depression, and inflammatory diseases such as rheumatoid arthritis and dermatitis [PMID:29126988].

Composés actifs

Active components include oligosaccharides (such as nystose, bajijiasu, and inulin-type oligosaccharides) [PMID:37991722, PMID:41338111], anthraquinones (e.g., M13, 3-hydroxy-1,2-dimethoxy-anthraquinone) [PMID:39706062, PMID:21582815], iridoids [PMID:36158563], monoterpenes [PMID:38382668], methyl 2-naphthoates [PMID:36403943], and the cyclohexene ether terpene glycoside monotropein [PMID:42150287].

Mécanisme d'action

Mechanisms vary by compound: oligosaccharides may regulate Mfn2-mediated mitophagy [PMID:36765376], inhibit the NOX4/mitoGPX4 pathway [PMID:40491951], or act via the IGF-1/PI3K/mTOR signaling pathway [PMID:41561043]; monotropein inhibits the cGAS/STING signaling pathway [PMID:42150287]; and extracellular vesicle-like particles (MOEVLPs) activate the MAPK/YAP1 signaling pathway [PMID:40377182].

Preuves cliniques

Preuve DDepression

Oligosaccharides mitigated depression-like behaviors in hypertension rats [PMID:36765376] and monotropein exerted antidepressant effects in LPS-induced mouse models [PMID:42150287].

Preuve DOsteoporosis

Polysaccharides (MOPs) attenuated osteoporosis in ovariectomized rats by suppressing the PGC-1α/PPARγ pathway [PMID:36369661] and regulating miR-214-3p/NEDD4L [PMID:39198270].

Preuve DAlzheimer's Disease

Oligosaccharides ameliorated memory in APP/PS1 transgenic mice by improving gut microbiota [PMID:29962999].

Preuve DMale Infertility/Sperm Motility

Oligosaccharides improved sperm motility and quality in gossypol-induced asthenozoospermia mouse models [PMID:41561043].

Preuve DOsteoarthritis

The anthraquinone M13 alleviated progression of osteoarthritis via regulation of STAT3 [PMID:39706062], and nystose mitigated knee osteoarthritis by inhibiting the NLRP3 inflammasome [PMID:41338111].

Preuve D

Sécurité et effets indésirables

Fermented Morinda officinalis (FMO) showed no genotoxicity in Ames or micronucleus tests and was regarded as non-toxic in acute and 90-day subchronic toxicity studies in mice and rats at doses up to 20 g/kg BW [PMID:35413384].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant anti-inflammatory, neuroprotective, and osteoprotective potential, though human clinical trials are not provided in the abstracts.

Sources PubMed

1.PMID: 36765376 (2023) — Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy. · Journal of neuroinflammation
2.PMID: 38663117 (2024) — Morinda Officinalis-derived extracellular vesicle-like particles: Anti-osteoporosis effect by regulating MAPK signaling pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 40377182 (2025) — Morinda Officinalis-Derived Extracellular Vesicle-like Particles Promote Wound Healing via Angiogenesis. · ACS applied materials & interfaces
4.PMID: 21582815 (2009) — 3-Hydr-oxy-1,2-dimethoxy-anthraquinone. · Acta crystallographica. Section E, Structure reports online
5.PMID: 40450983

Morinda Officinalis

Sources et citations