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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Common mullein (Verbascum thapsus L.) is a medicinal plant used traditionally for pulmonary, inflammatory, and wound-related conditions [PMID:16222647, PMID:35088467].
Contexte
Verbascum thapsus L., also known as great mullein or common mullein, is a biennial plant indigenous to Europe, northern Africa, and western and central Asia, and has been introduced to the Americas and Australia [PMID:35088467, PMID:37009556].
Usages traditionnels
It has been used to treat pulmonary problems, inflammatory diseases, asthma, spasmodic coughs, diarrhoea, migraine headaches [PMID:16222647], lung, skin, and throat disorders [PMID:35088467], and as an antispasmodic, anti-tubercular agent, and wormicide in tribal medicine [PMID:22463730]. Root extracts have been used for toothache, stiffness, and seizures [PMID:35088467], while other traditional uses include treating genitourinary infections [PMID:26239850] and whooping cough [PMID:39183880].
Composés actifs
Phytoconstituents include flavonoids, saponins, tannins, terpenoids, glycosides (iridoid, phenylethanoid, and phenylpropanoid), coumarin, hesperidin, and vitamin C [PMID:35088467, PMID:22463730]. Specific identified compounds include p-coumaric acid, ferulic acid, rutin [PMID:36297503], and acteoside [PMID:40549319].
Mécanisme d'action
Traditional uses may rely on the anti-inflammatory action of phytochemicals such as quercetin [PMID:34356473]. In vitro studies suggest the plant may induce apoptosis in Trichomonas vaginalis [PMID:26239850] and exhibit antioxidant activity via DPPH and ABTS radical scavenging [PMID:38279434, PMID:31456524].
Preuves cliniques
Preuve BEpisiotomy wound healing
A randomized, double-blind, controlled clinical trial evaluated the effect of Verbascum Thapsus on episiotomy wound healing in primiparous women [PMID:34103042].
Sécurité et effets indésirables
Toxicity to brine shrimp and radish seed germination was observed at higher concentrations of extracts [PMID:12241986].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal/plant bioassays, and reviews of traditional use, with one randomized controlled trial regarding wound healing. Overall clinical evidence in humans is limited.
Sources PubMed
1.PMID: 16222647 (2005) — Common mullein (Verbascum thapsus L.): recent advances in research. · Phytotherapy research : PTR
2.PMID: 35088467 (2022) — Health-promoting and disease-mitigating potential of Verbascum thapsus L. (common mullein): A review. · Phytotherapy research : PTR
3.PMID: 22463730 (2012) — Anthelmintic and relaxant activities of Verbascum Thapsus Mullein. · BMC complementary and alternative medicine
4.PMID: 36297503 (2022) — Gold Nanoparticles Synthesized with Common Mullein (Verbascum thapsus) and Castor Bean (Ricinus communis) Ethanolic Extracts Displayed Antiproliferative Effects and Induced Caspase 3 Activity in Human HT29 and SW480 Cancer Cells. · Pharmaceutics
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L.
· Medicinal chemistry (Shariqah (United Arab Emirates))
6.PMID: 12241986 (2002) — Biological activity of common mullein, a medicinal plant. · Journal of ethnopharmacology
7.PMID: 36082042 (2022) — The complete chloroplast genome of Verbascum thapsus L. (Scrophulariaceae) and its phylogenetic affinities. · Mitochondrial DNA. Part B, Resources
8.PMID: 37009556 (2023) — The Complete Genome Sequence of Verbascum thapsus (Scrophulariaceae, Lamiales), the Common Mullein. · Biodiversity genomes
9.PMID: 34356473 (2021) — Searching for Scientific Explanations for the Uses of Spanish Folk Medicine: A Review on the Case of Mullein (Verbascum, Scrophulariaceae). · Biology
10.PMID: 26239850 (2015) — Effect of Verbascum thapsus ethanol extract on induction of apoptosis in Trichomonas vaginalis in vitro. · Infectious disorders drug targets
11.PMID: 38279434 (2023) — Antioxidant, AChE inhibitory, and anticancer effects of Verbascum thapsus extract. · Cellular and molecular biology (Noisy-le-Grand, France)
12.PMID: 34103042 (2021) — The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial. · BMC complementary medicine and therapies
13.PMID: 39183880 (2024) — Bioassay-guided fractionation of Verbascum thapsus extract and its combination with polyvinyl alcohol in the form electrospun nanofibrous membrane for efficient wound dressing application. · Heliyon
14.PMID: 40549319 (2025) — Acteoside as a multifunctional natural glycoside: therapeutic potential across various diseases. · Inflammopharmacology