Murraya Paniculata (Murraya paniculata): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Murraya paniculata work medicinally?

Murraya paniculata contains bioactive compounds including murrayacoumarin, paniculatin, alkaloids, limonoids, and essential oils that contribute to its medicinal properties. These compounds are believed to exert analgesic and antimicrobial effects through anti-inflammatory pathways and direct antimicrobial action. The essential oils may provide additional therapeutic benefits. However, specific mechanisms have not been fully established in human clinical trials. Evidence Level: C.

Does Murraya paniculata interact with blood thinners?

Murraya paniculata is contraindicated for individuals taking blood thinners (anticoagulants) due to potential interactions. While specific clinical interaction studies are lacking, traditional use patterns and the presence of bioactive compounds suggest possible effects on blood clotting. Patients on warfarin, aspirin, or other anticoagulant medications should avoid this herb. Always consult a healthcare provider before combining herbal supplements with prescription blood thinners. Evidence Level: C.

What is the recommended dosage for Murraya paniculata?

The traditional adult dosage for Murraya paniculata is 2-4 grams of dried leaf or bark prepared as a tea, taken once daily. This dosing recommendation is based on traditional use in Malaysian and Indian folk medicine rather than standardized clinical trials. Commercial extracts or supplements may have different potency and dosing requirements. Consult a qualified healthcare provider or medical herbalist for personalized dosing guidance. Evidence Level: Traditional.

Is Murraya paniculata safe during pregnancy?

Murraya paniculata is considered unsafe during pregnancy and is contraindicated for pregnant women. Traditional medicine systems, including Malaysian and Ayurvedic practices, advise against its use in pregnancy. Clinical safety data in pregnant women is lacking, but the presence of bioactive alkaloids and other compounds raises potential concerns. Women who are pregnant or breastfeeding should avoid Murraya paniculata. Evidence Level: C.

What are the side effects of Murraya paniculata?

Reported side effects of Murraya paniculata include gastrointestinal upset and skin sensitization in some individuals. These effects are generally mild but may vary depending on dosage, preparation method, and individual sensitivity. Allergic skin reactions can occur with topical use. Discontinue use if adverse symptoms develop and seek medical advice if symptoms persist or worsen. Evidence Level: Traditional.

What is Murraya paniculata used for in traditional medicine?

Murraya paniculata is used in Malaysian traditional medicine, Ayurvedic folk remedies, and Indonesian herbal practice primarily for its analgesic (pain-relieving) and antimicrobial properties. The bark and leaves are traditionally prepared as teas or topical applications. Common traditional applications include treating minor pain, wounds, and infections. Scientific evidence supporting these uses is preliminary. Evidence Level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Murraya paniculata, commonly known as orange jasmine, is an evergreen plant of the Rutaceae family with diverse pharmacological properties including anti-diabetic, antioxidant, and cholinesterase inhibitory activities [PMID:37007290, PMID:36529712].

Contexte

Murraya paniculata (L.) Jack is an ornamental evergreen plant native to Asia and found in tropical and subtropical regions [PMID:37340448, PMID:30764113]. It is a member of the Rutaceae family and is closely related to the Citrus genus [PMID:37007290, PMID:30744239].

Usages traditionnels

Traditionally used in folk medicine as a remedy for cardiovascular, intestinal, and respiratory disorders [PMID:36529712]. In Traditional Chinese Medicine (as Murrayae Folium et Cacumen), it is used to treat stomach aches, rheumatism, toothaches, swelling, insect and snake bites, and to promote blood circulation and alleviate pain [PMID:38606170, PMID:40020792, PMID:34450164].

Composés actifs

The plant contains a wide range of phytochemicals including phenols, coumarins (such as murrmeranzin, murralonginal, and paniculatin), terpenoids, flavonoids, alkaloids, and trigonelline [PMID:36529712, PMID:18470803, PMID:25115081]. Essential oils from the leaves contain $\beta$-phellandrene, germacrene D, and $\delta$-elemene [PMID:37516925].

Mécanisme d'action

Total flavonoids from the leaves may prevent acetaminophen-induced liver injury by activating the Keap1/Nrf2 and PI3K/AKT/mTOR signaling pathways [PMID:40020792]. Certain coumarins act as mixed-type inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) [PMID:36969847]. Network pharmacology suggests potential targets for anti-obesity effects include EP300, PPARG, and PPARGC1A [PMID:39208245].

Preuves cliniques

Preuve DDiabetes

Hydroalcoholic extract of M. paniculata decreased glycemia, cholesterol, and triglyceride levels in alloxan-induced diabetic rats [PMID:28840616]

Preuve DAnxiety and Depression

Leaf extracts demonstrated antianxiety and antidepressant activity in animal models (elevated plus maze and forced swim test) [PMID:28659237]

Preuve DLiver Injury

Total flavonoids from leaves showed hepatoprotective effects against acetaminophen-induced acute liver injury in experimental animals [PMID:40020792]

Preuve DCholinesterase Inhibition

Leaf essential oils and specific coumarins showed strong inhibitory activity against AChE and BChE in vitro [PMID:37516925, PMID:36969847]

Preuve DBacterial/Fungal Infections

Essential oils demonstrated antibacterial and antifungal activity in vitro [PMID:27927082]

Synthèse des preuves

The current evidence is primarily based on in vitro studies, animal models, and literature reviews; there are no human clinical trials provided in the abstracts.

Sources PubMed

1.PMID: 37007290 (2023) — A Brief Review on Murraya paniculata (Orange Jasmine): pharmacognosy, phytochemistry and ethanomedicinal uses. · Journal of pharmacopuncture
2.PMID: 37340448 (2023) — Chromosome-level genome assembly of Murraya paniculata sheds light on biosynthesis of floral volatiles. · BMC biology
3.PMID: 36529712 (2023) — Diversity in Phytochemical Composition and Medicinal Value of Murraya paniculata. · Chemistry & biodiversity
4.PMID: 38657079 (2024) — Natural Infection of Murraya paniculata and Murraya sumatrana with 'Candidatus Liberibacter asiaticus' in Java. · Plant disease
5.PMID: 37516925 (2024) — Anticholinesterases activity of Murraya koenigii (L.) Spreng. and Murraya paniculata (L.) Jacq. essential oils with GC/MS analysis and molecular docking.

Murraya Paniculata

Sources et citations

Calculer une dose sûre de Murraya Paniculata