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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Nardostachys grandiflora
Himalayan herb closely related to jatamansi; used in Ayurveda, Unani, and historically as the biblical anointing oil spikenard.
Nardostachys grandiflora, also known as Nardus Indica or spikenard, is a Himalayan herb traditionally used in Ayurveda and Unani medicine as a nervine, cardiac tonic, and sedative. Its primary active compounds include nardosinone, nardostachone, and jatamansone, which contribute to its anxiolytic, sedative, and antifungal properties. Despite its historical and modern therapeutic applications, the herb is critically endangered due to overharvesting, and its use requires caution, especially during pregnancy and with concurrent sedative medications.
Nardostachys grandiflora exerts its anxiolytic and sedative effects primarily through modulation of GABAergic neurotransmission, with nardosinone and valeranone acting as positive allosteric modulators of GABA-A receptors, enhancing chloride ion conductance. Additionally, jatamansone exhibits dopaminergic and serotonergic receptor affinity, contributing to mood stabilization and cardiac tonic effects. The antifungal activity is attributed to sesquiterpenoids like nardostachone, which disrupt fungal cell membrane integrity. The herb also demonstrates antioxidant and anti-inflammatory actions via inhibition of NF-κB and COX-2 pathways.
Himalayan herb closely related to jatamansi; used in Ayurveda, Unani, and historically as the biblical anointing oil spikenard.
Nardostachys grandiflora, also known as Nardus Indica or spikenard, is a Himalayan herb traditionally used in Ayurveda and Unani medicine as a nervine, cardiac tonic, and sedative. Its primary active compounds include nardosinone, nardostachone, and jatamansone, which contribute to its anxiolytic, sedative, and antifungal properties. Despite its historical and modern therapeutic applications, the herb is critically endangered due to overharvesting, and its use requires caution, especially during pregnancy and with concurrent sedative medications.
Nardostachys grandiflora exerts its anxiolytic and sedative effects primarily through modulation of GABAergic neurotransmission, with nardosinone and valeranone acting as positive allosteric modulators of GABA-A receptors, enhancing chloride ion conductance. Additionally, jatamansone exhibits dopaminergic and serotonergic receptor affinity, contributing to mood stabilization and cardiac tonic effects. The antifungal activity is attributed to sesquiterpenoids like nardostachone, which disrupt fungal cell membrane integrity. The herb also demonstrates antioxidant and anti-inflammatory actions via inhibition of NF-κB and COX-2 pathways.