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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Nerium oleander
Mediterranean ornamental shrub; all parts extremely toxic (oleandrin); historical use in cancer treatment.
Nerium oleander is a highly toxic Mediterranean shrub historically used in traditional medicine for cancer, heart conditions, and skin ailments. Its primary active compound, oleandrin, is a cardiac glycoside that inhibits Na+/K+-ATPase, leading to increased cardiac contractility but also severe toxicity. Despite some limited research into its anticancer potential, the plant's extreme toxicity precludes any safe internal use.
Oleandrin and related cardiac glycosides bind to and inhibit the Na+/K+-ATPase pump, increasing intracellular sodium and calcium via the Na+/Ca2+ exchanger, resulting in positive inotropy and potential for fatal arrhythmias. Additionally, oleandrin may induce apoptosis in cancer cells through inhibition of NF-κB and activation of caspases, though these effects are inseparable from cardiotoxicity. The compound also exhibits anti-inflammatory and antiviral activities in vitro, but clinical translation is limited by narrow therapeutic index.
Mediterranean ornamental shrub; all parts extremely toxic (oleandrin); historical use in cancer treatment.
Nerium oleander is a highly toxic Mediterranean shrub historically used in traditional medicine for cancer, heart conditions, and skin ailments. Its primary active compound, oleandrin, is a cardiac glycoside that inhibits Na+/K+-ATPase, leading to increased cardiac contractility but also severe toxicity. Despite some limited research into its anticancer potential, the plant's extreme toxicity precludes any safe internal use.
Oleandrin and related cardiac glycosides bind to and inhibit the Na+/K+-ATPase pump, increasing intracellular sodium and calcium via the Na+/Ca2+ exchanger, resulting in positive inotropy and potential for fatal arrhythmias. Additionally, oleandrin may induce apoptosis in cancer cells through inhibition of NF-κB and activation of caspases, though these effects are inseparable from cardiotoxicity. The compound also exhibits anti-inflammatory and antiviral activities in vitro, but clinical translation is limited by narrow therapeutic index.