Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Notopterygium root contains active compounds including notopterol, isoimperatorin, and bergapten that exhibit anti-inflammatory and analgesic properties. These compounds work by inhibiting inflammatory mediators and improving microcirculation in affected tissues. In Traditional Chinese Medicine theory, the herb releases exterior cold and expels wind-cold-damp pathogens, addressing the underlying cause of pain. It has a particular affinity for the upper body, making it especially effective for neck, shoulder, and upper back pain. Evidence level: C.
Does Notopterygium root interact with any medications?
Notopterygium root may interact with anticoagulant and antiplatelet medications due to its effects on blood circulation. The herb contains furanocoumarins such as bergapten, which can affect liver enzyme activity and potentially alter the metabolism of certain pharmaceutical drugs. Patients taking blood thinners like warfarin or aspirin should exercise caution and consult a healthcare provider. The herb's sweating-promoting properties may also compound effects with diuretics. Evidence level: C.
What is the recommended dosage for Notopterygium root?
The standard adult dosage for dried Notopterygium root is 3-9 grams per day, typically prepared as a decoction boiled in water. For acute conditions such as cold-induced headaches or upper body pain, practitioners may recommend doses toward the higher end of this range. The herb is commonly combined with other wind-expelling herbs in formulated prescriptions. Always consult a qualified herbalist for personalized dosing, as individual constitution affects appropriate amounts. Evidence level: Traditional.
Is Notopterygium root safe during pregnancy?
Notopterygium root is considered unsafe during pregnancy and should be avoided. The herb has strong exterior-releasing and sweat-promoting properties that may disrupt pregnancy. Its active compounds, including notopterol and various coumarins, may stimulate uterine activity or affect fetal development. The herb's blood-moving and dispersing qualities pose additional risks during gestation. Breastfeeding women should also avoid this herb due to insufficient safety data. Pregnant patients should consult their healthcare provider for appropriate alternatives. Evidence level: C.
What is Notopterygium root used for in TCM?
Notopterygium root is used in Traditional Chinese Medicine to release exterior cold and expel wind-cold-damp from the body. It is particularly effective for upper body pain, including neck stiffness, shoulder discomfort, and upper back aches. The herb also treats headaches caused by cold patterns, especially those affecting the occipital region or accompanied by body aches. Its anti-inflammatory properties make it useful for joint pain associated with cold-damp conditions. Evidence level: C.
What are the side effects of taking Notopterygium root?
The most common side effect of Notopterygium root is nausea, particularly when taken in doses exceeding the recommended 3-9 gram range. Overdose may cause excessive sweating, dizziness, or digestive discomfort. The herb is contraindicated for individuals with blood deficiency without wind, as its dispersing properties can further deplete blood and yin. Those with excessive sweating disorders should avoid this herb. Some individuals may experience photosensitivity due to furanocoumarin content. Evidence level: Traditional.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Notopterygium incisum (Qianghuo) is a Chinese endemic herb used in traditional medicine for its anti-inflammatory, analgesic, and antipyretic properties [PMID:39064831, PMID:39094757].
Contexte
Notopterygium incisum is a plant of the Apiaceae (Umbelliferae) family endemic to China, typically growing in high-altitude regions such as Tibet, Gansu, Qinghai, and Sichuan [PMID:39064831, PMID:28336469, PMID:32211172]. The medicinal parts are the roots and rhizomes [PMID:39064831, PMID:19781618].
Usages traditionnels
It is used in traditional Chinese medicine to treat headaches, colds, rheumatoid arthritis, and inflammatory conditions [PMID:39064831, PMID:39094757, PMID:31908072]. It is specifically used to disperse 'cold' and treat wind-cold exterior syndrome and wind-cold-damp bi-syndromes [PMID:28336469, PMID:36587876]. It is a primary component of Qianghuo Yufeng Decoction used for dementia, mental paralysis, and liver/kidney insufficiency [PMID:39094757].
Composés actifs
The root contains over 500 compounds, including volatile oils, coumarins (such as notopterol and isoimperatorin), enynes, sesquiterpenes, flavonoids, organic acids, esters, and polysaccharides [PMID:39064831, PMID:40020461, PMID:41053923, PMID:37143438]. Specific bioactive constituents include ferulic acid derivatives and phenolic compounds [PMID:38685511, PMID:35926428].
Mécanisme d'action
Mechanisms include inhibition of the TLR4-NF-κB pathway in neuroinflammation [PMID:39094757], regulation of TRPA1 to alleviate cold allodynia [PMID:36587876], and inhibition of the PI3K/Akt/GPX4-mediated ferroptosis in osteoarthritis [PMID:40020461]. Other identified pathways include the cAMP signaling pathway [PMID:41053923], JAK/STAT3 signaling [PMID:37143438], and the PI3K/AKT pathway [PMID:38867371].
Preuves cliniques
Preuve DAlzheimer's Disease (Mice)
Root extract (NRE) may inhibit Aβ release, tau activation, and alleviate neuroinflammation via the TLR4-NF-κB pathway [PMID:39094757].
Preuve DEpilepsy (Mice)
NRE (1 g/kg/d) ameliorated epileptiform symptoms and improved cognitive dysfunction in PTZ-induced acute seizure mice [PMID:35388767].
Preuve DNeuropathic Pain (Mice)
Water extract reduced cold allodynia by regulating TRPA1 [PMID:36587876].
Preuve DOsteoarthritis (Mice/Rats)
Notopterol inhibited PI3K/Akt/GPX4-mediated ferroptosis, reducing pain and cartilage degradation [PMID:40020461]; Isoimperatorin reduced synovial inflammation via the cAMP pathway [PMID:41053923].
Preuve DRheumatoid Arthritis (Rats/Cells)
N. incisum polysaccharides (NIP) relieved toe redness and swelling and inhibited NF-κB and JAK/STAT3 pathways [PMID:37143438].
Preuve DColorectal Cancer (Cell lines)
Synthèse des preuves
The current evidence is based primarily on in vitro cell studies and in vivo animal models (mice/rats), indicating strong pharmacological potential for anti-inflammatory and neuroprotective effects, but lacks human clinical trial data.
Sources PubMed
1.PMID: 39064831 (2024) — Phytochemistry and Biological Profile of the Chinese Endemic Herb Genus Notopterygium. · Molecules (Basel, Switzerland)
2.PMID: 39094757 (2024) — Notopterygium incisum roots extract (NRE) alleviates neuroinflammation pathology in Alzheimer's disease through TLR4-NF-κB pathway. · Journal of ethnopharmacology
4.PMID: 36587876 (2023) — Water extract of Notopterygium incisum alleviates cold allodynia in neuropathic pain by regulation of TRPA1. · Journal of ethnopharmacology
5.PMID: 28336469 (2017) — A review of the ethnopharmacology, phytochemistry and pharmacology of Notopterygium incisum.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Notopterol (20 mg/kg) improved exercise capacity and suppressed P2X7R and pyroptosis signals [PMID:36986461].
· Journal of ethnopharmacology
6.PMID: 32211172 (2020) — Potential distribution of Notopterygium incisum Ting ex H. T. Chang and its predicted responses to climate change based on a comprehensive habitat suitability model. · Ecology and evolution
7.PMID: 38685511 (2024) — Chemical constituents from Notopterygium incisum and their anti-neuroinflammatory activity. · Fitoterapia
8.PMID: 38867371 (2024) — Two Undescribed Coumarins from Notopterygium Incisum with Anti-Inflammatory Activity. · Chemistry & biodiversity
9.PMID: 31908072 (2020) — Rapid discrimination of Notopterygium incisum and Notopterygium franchetii based on characteristic compound profiles detected by UHPLC-QTOF-MS/MS coupled with multivariate analysis. · Phytochemical analysis : PCA
10.PMID: 40020461 (2025) — Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis. · International immunopharmacology
11.PMID: 32106026 (2020) — Rapid and intelligent discrimination of Notopterygium incisum and Notopterygium franchetii by infrared spectroscopic fingerprints and electronic olfactory fingerprints. · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
12.PMID: 39220882 (2024) — The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins. · Acta pharmaceutica Sinica. B
13.PMID: 38967889 (2024) — Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer. · Current medical science
14.PMID: 35926428 (2022) — Nitric oxide inhibitory phenolic constituents isolated from the roots and rhizomes of Notopterygium incisum. · Bioorganic chemistry
15.PMID: 37143438 (2023) — Structure Characterization and Anti-Rheumatoid Arthritis Activity of a Polysaccharide from Notopterygium incisum. · Molecular nutrition & food research
16.PMID: 41053923 (2025) — Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway. · Journal of cellular and molecular medicine
18.PMID: 37719850 (2023) — Active metabolites and potential mechanisms of Notopterygium incisum against obstructive sleep apnea Syndrome (OSAS): network analysis and experimental assessment. · Frontiers in pharmacology
19.PMID: 19781618 (2009) — Quantitative analysis of chemical constituents in different commercial parts of Notopterygium incisum by HPLC-DAD-MS. · Journal of ethnopharmacology
20.PMID: 30195388 (2018) — Notopterygium incisum extract and associated secondary metabolites inhibit apple fruit fungal pathogens. · Pesticide biochemistry and physiology
21.PMID: 35390234 (2023) — A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways. · Journal of basic and clinical physiology and pharmacology
22.PMID: 42174439 (2026) — Phenotyping elucidates the association between traits and bioactive components in Notopterygium incisum. · BMC plant biology
23.PMID: 21856104 (2011) — Discrimination of the seeds of Notopterygium incisum and Notopterygium franchetii by validated HPLC-DAD-ESI-MS method and principal component analysis. · Journal of pharmaceutical and biomedical analysis
24.PMID: 2285981 (1990) — Isolation of two new coumarin glycosides from Notopterygium forbesii and evaluation of a Chinese crude drug, qiang-huo, the underground parts of N. incisum and N. forbesii, by high-performance liquid chromatography. · Chemical & pharmaceutical bulletin
25.PMID: 27669203 (2016) — Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. · Molecules (Basel, Switzerland)
26.PMID: 32599231 (2020) — Structural analyses of the HG-type pectin from notopterygium incisum and its effects on galectins. · International journal of biological macromolecules
27.PMID: 40122302 (2025) — Bioactive coumarins from Notopterygium incisum root: A step toward natural ant-infammatory candidates. · Fitoterapia
28.PMID: 41920256 (2026) — Mechanistic Topology of Notopterygium incisum Essential Oil against Rheumatoid Arthritis: Machine Learning-Guided CASP1 Screening and Nanoemulsion Evaluation. · Chinese journal of integrative medicine
29.PMID: 29890940 (2018) — Molecular mechanism of seed dormancy release induced by fluridone compared with cod stratification in Notopterygium incisum. · BMC plant biology