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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Oenanthe crocata, also known as hemlock water dropwort, is a highly toxic plant found in Western Europe and North America, often resulting in fatal poisonings when roots are mistaken for edible plants [PMID: 657757, 32473868].
Contexte
Oenanthe crocata is a member of the Apiaceae family that grows in humid grasslands and wet meadows of Western Europe, including the British Isles and France [PMID: 32473868, 945171, 657757]. It is considered one of the most poisonous plants in the British Isles [PMID: 657757, 32539046].
Composés actifs
The primary toxins are polyacetylenes, specifically oenanthotoxin and its hydrogenated metabolite, 2,3-dihydro-oenanthotoxin [PMID: 35189181, 16730246, 32539046]. The aerial parts contain an essential oil composed mainly of monoterpene hydrocarbons, including trans-β-ocimene, sabinene, and cis-β-ocimene [PMID: 24012643, 19347799]. A non-toxic crystalline principle called crocatone has also been identified [PMID: 13240334].
Mécanisme d'action
Oenanthotoxin and dihydro-oenanthotoxin act as proconvulsants by blocking GABAergic responses and antagonizing the γ-aminobutyric acid (GABA) system in the human brain, which normally provides inhibitory neuronal action [PMID: 19245244, 32539046, 22445880].
Preuves cliniques
Preuve DPlant Poisoning
Ingestion of roots can lead to prolonged convulsions, severe metabolic acidosis, respiratory distress, cardiac arrest, and death [PMID: 3671269, 32473868].
Preuve DHIV-1 Activity
Essential oils of O. crocata inhibited HIV-1 reverse transcriptase RNA-dependent DNA polymerase (RDDP) activity in biochemical assays [PMID: 19347799].
Preuve DInflammation/Fungal Infection
Essential oil demonstrated antifungal activity against dermatophytes and Cryptococcus neoformans, and anti-inflammatory activity via nitric oxide production inhibition [PMID: 24012643].
Sécurité et effets indésirables
The plant is extremely toxic, particularly the roots [PMID: 657757]. Adverse effects include vomiting, diarrhea, abdominal pain, confusion, drowsiness, headache, myosis, ophthalmoplegia, rhabdomyolysis, and severe convulsions [PMID: 18206356, 3671269, 32473868]. Fatalities have been reported in humans and animals (e.g., Arabian horses) [PMID: 35189181, 32473868].
Synthèse des preuves
The available evidence consists primarily of case reports of poisoning (Level D), biochemical assays (Level D), and toxicological reviews (Level C). There are no RCTs or systematic reviews regarding therapeutic use.
Sources PubMed
1.PMID: 35189181 (2022) — Analytical documentation of an Arabian horse fatality related to Oenanthe crocata poisoning. · Toxicon : official journal of the International Society on Toxinology
2.PMID: 3671269 (1987) — Hemlock water dropwort poisoning. · Postgraduate medical journal
4.PMID: 32473868 (2020) — Oenantha Crocata: A Case Report of Multiple Poisoning with Fatal Outcome. · The Journal of emergency medicine
5.PMID: 16730246 (2006) — Application of liquid chromatography-mass spectrometry to the investigation of poisoning by Oenanthe crocata.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
· Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
6.PMID: 24012643 (2013) — Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oil. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
7.PMID: 945171 (1976) — [Fatal poisoning by water dropwort (Oenanthe crocata)]. · European journal of toxicology and environmental hygiene. Journal europeen de toxicologie
8.PMID: 19347799 (2009) — HIV-1-inhibiting activity of the essential oil of Ridolfia segetum and Oenanthe crocata. · Planta medica
9.PMID: 19245244 (2009) — Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus. · Journal of natural products
10.PMID: 13240334 (1955) — [Crocatone, the non-toxic crystalline principle from Oenanthe crocata L. (Umbelliferae)]. · Bulletin de la Societe de chimie biologique
11.PMID: 22445880 (2012) — Inhibitory effects of oenanthotoxin analogues on GABAergic currents in cultured rat hippocampal neurons depend on the polyacetylenes' polarity. · European journal of pharmacology
12.PMID: 32539046 (2020) — Three poisonous plants (Oenanthe, Cicuta and Anamirta) that antagonise the effect of γ-aminobutyric acid in human brain. · The journal of the Royal College of Physicians of Edinburgh
13.PMID: 18206356 (2008) — [Child poisoning after ingestion of a wild apiaceae: a case report]. · Archives de pediatrie : organe officiel de la Societe francaise de pediatrie