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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
PubMed · Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation. (2015)
PubMed · <i>Oroxylum indicum</i> (L.) kurz as a promising Anticancer resource: bridging ethnopharmacology, biotechnology, and conservation perspectives. (2026)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Oroxylum Indicum
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
Oroxylum indicum contains active flavonoids, primarily baicalein and chrysin, which exert anti-inflammatory and antioxidant effects. These compounds inhibit pro-inflammatory cytokines and oxidative stress markers, supporting the herb's traditional use for respiratory conditions and joint disorders. Evidence Level C suggests these mechanisms are observed in preclinical studies, though human clinical trials remain limited.
Can I take Oroxylum indicum with anticoagulants or blood thinners?
No, you should avoid Oroxylum indicum if you are taking anticoagulants. The herb contains flavonoids like baicalein that may possess anti-platelet properties, potentially increasing the risk of bleeding when combined with blood-thinning medications. This interaction is a recognized contraindication. Patients on warfarin or similar drugs should consult a physician before use.
What is the recommended dosage for Oroxylum indicum?
The standard adult dosage for Oroxylum indicum is 3 to 5 grams of bark or seed powder daily. This recommendation is based on traditional Ayurvedic and Thai medicine practices (Evidence Level D). Users should divide the dose throughout the day to minimize gastric irritation. It is advisable to start with a lower dose to assess individual tolerance.
Is Oroxylum indicum safe during pregnancy?
No, Oroxylum indicum is considered unsafe during pregnancy. Traditional use and safety classifications contraindicate its use for expectant mothers due to potential risks. The herb may stimulate uterine contractions or cause other complications. Breastfeeding women should also avoid this herb due to a lack of safety data regarding infant exposure.
What are the benefits of Oroxylum indicum for bone fractures?
Oroxylum indicum is widely used in Ayurveda to accelerate bone healing and treat fractures. Traditional practitioners believe it helps reunite broken bones, earning it names like 'Bone Knit.' While animal studies suggest potential osteoprotective effects, Evidence Level C indicates that robust human clinical trials are necessary to confirm these specific bone-healing properties.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Oroxylum indicum, also known as the Indian trumpet tree, is an Asian medicinal plant used in traditional systems like Ayurveda for various therapeutic purposes [PMID:25543018, PMID:41849733]. It is recognized for its wide range of pharmacological activities, including antioxidant, anti-inflammatory, and neuroprotective effects [PMID:33276419, PMID:41849733].
Contexte
Oroxylum indicum (L.) Kurz is an endangered medicinal species of the Bignoniaceae family widely distributed throughout Asia [PMID:33276419, PMID:41849733]. It is a key component of Ayurvedic formulations such as Dashamoola and Chyawanprash [PMID:41849733].
Usages traditionnels
It has been used for centuries in Asia to prevent and treat jaundice, arthritic and rheumatic problems, gastric ulcers, tumors, respiratory diseases, diabetes, diarrhea, dysentery, and non-healing ulcers [PMID:25543018, PMID:38805854].
Composés actifs
The plant is rich in flavonoids, most notably baicalein, baicalin, oroxylin A, chrysin, oroxin A, and oroxin B [PMID:33276419, PMID:41154001, PMID:41849733]. Other identified compounds include phenolic glycosides such as oroxylumosides A and B, darendoside A, leucosceptoside A, acteoside, and decaffeoylacteoside [PMID:33078632], as well as 5,6,7-trimethoxyflavone-8-O-β-D-glucopyranoside [PMID:25675364].
Mécanisme d'action
Pharmacological effects are mediated through the inhibition of NF-κB, modulation of ROS-mediated apoptosis, and glucose uptake modulation [PMID:41849733]. Specific compounds like oroxylin A modulate signaling pathways including MAPK, ERK1/2, Wnt/β-catenin, and PTEN/PI3K/Akt [PMID:36139025]. Other mechanisms include the upregulation of BDNF gene expression [PMID:38931243] and the targeting of Lactate Dehydrogenase A (LDHA) [PMID:36583135].
Preuves cliniques
Preuve BMild Cognitive Impairment
A 12-week randomized, double-blind, placebo-controlled trial found that 500 mg of standardized extract twice daily was associated with greater improvements in episodic memory and computer-based cognitive tasks compared to placebo [PMID:34531736]
Preuve BHepatocellular Carcinoma (HCC)
Oroxylin A tablets are currently undergoing phase Ib/IIa clinical trials for the treatment of HCC [PMID:40653321]
Preuve DChemotherapy-Induced Cognitive Impairment
In male C57BL/6J mice, Oroxylum indicum extract significantly prevented impairments in short-term cognitive performance, spatial learning, and memory following doxorubicin and cyclophosphamide treatment [PMID:34081735]
Preuve DDoxorubicin-Induced Cardiotoxicity
Root bark extract prevented cardiac damage in female Sprague Dawley rats by restoring redox balance [PMID:29398409]; extract (Sabroxy®) also showed cardioprotective effects against doxorubicin and cyclophosphamide in male mice [PMID:34623620]
Preuve DCancer (General/Solid Tumors)
Root bark extract inhibited solid and ascites tumors (DLA and EAC) and prevented DMBA-induced skin papilloma formation in mice [PMID:36500567]
Sécurité et effets indésirables
Toxicological studies indicate a wide safety margin [PMID:41849733]. Baicalin and baicalein have shown almost no toxicity to normal human epithelial, peripheral, and myeloid cells [PMID:28288320].
Synthèse des preuves
The evidence consists primarily of preclinical in vitro and in vivo animal studies (Level D) and systematic reviews (Level C). There is limited clinical evidence from one randomized controlled trial regarding cognitive function (Level B) and ongoing phase Ib/IIa trials for hepatocellular carcinoma (Level B).
Sources PubMed
1.PMID: 33078632 (2022) — Phenolic glycosides from Oroxylum indicum. · Natural product research
2.PMID: 25543018 (2015) — Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation. · Journal of ethnopharmacology
3.PMID: 33276419 (2020) — The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review. · Molecules (Basel, Switzerland)
4.PMID: 41849733 (2026) — Oroxylum indicum (L.) kurz as a promising Anticancer resource: bridging ethnopharmacology, biotechnology, and conservation perspectives. · Natural product research
5.PMID: 34623620 (2022) — Cardioprotective Effects of Oroxylum indicum Extract Against Doxorubicin and Cyclophosphamide-Induced Cardiotoxicity.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Seed extract significantly alleviated anhedonia and despair behaviors in a mouse model of unpredictable chronic mild stress by normalizing HPA axis function [PMID:38004136]
7.PMID: 41154001 (2025) — A Systematic Review of Evidence-Based Health Benefits of Oroxylum indicum and Its Functional Food Potential. · Foods (Basel, Switzerland)
8.PMID: 40650065 (2025) — The Neuroprotective Potential of Seed Extract from the Indian Trumpet Tree Against Amyloid Beta-Induced Toxicity in SH-SY5Y Cells. · International journal of molecular sciences
9.PMID: 25675364 (2015) — One new flavonoid from Oroxylum indicum. · Natural product research
10.PMID: 36139025 (2022) — Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases. · Biomolecules
11.PMID: 32733583 (2020) — Systematic Elucidation of the Mechanism of Oroxylum indicum via Network Pharmacology. · Evidence-based complementary and alternative medicine : eCAM
12.PMID: 38873988 (2024) — Molecular targets and therapeutic potential of baicalein: a review. · Drug target insights
13.PMID: 39124228 (2024) — A Comparative Study of Two Oroxylum indicum (L.) Kurz. Phenotypes Based on Phytochemicals and Antioxidant Effects, and the Anti-Inflammatory Activity of Leaf and Pod Extracts. · Plants (Basel, Switzerland)
14.PMID: 29434399 (2018) — Anti-viral Activities of Oroxylum indicum Extracts on Chikungunya Virus Infection. · Indian journal of microbiology
15.PMID: 38931243 (2024) — The Neuroprotective Effects of Oroxylum indicum Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression under LPS Induced Inflammation. · Nutrients
16.PMID: 37493468 (2024) — Identification of potential sclerostin inhibiting flavonoids from Oroxylum indicum: an insilico approach. · Journal of biomolecular structure & dynamics
17.PMID: 29398409 (2019) — Oroxylum indicum root bark extract prevents doxorubicin-induced cardiac damage by restoring redox balance. · Journal of Ayurveda and integrative medicine
18.PMID: 36583135 (2023) — Anticancer potential of phytochemicals from Oroxylum indicum targeting Lactate Dehydrogenase A through bioinformatic approach. · Toxicology reports
19.PMID: 38805854 (2024) — In-silico evaluation of Oroxylum indicum vent compounds in the plausible treatment and prevention of nasopharyngeal cancer. · Journal of Ayurveda and integrative medicine
20.PMID: 34531736 (2021) — Effects of an Oroxylum indicum Extract (Sabroxy®) on Cognitive Function in Adults With Self-reported Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Study. · Frontiers in aging neuroscience
21.PMID: 36500567 (2022) — Root Bark Extract of Oroxylum indicum Vent. Inhibits Solid and Ascites Tumors and Prevents the Development of DMBA-Induced Skin Papilloma Formation. · Molecules (Basel, Switzerland)
22.PMID: 38417609 (2024) — Cellular and molecular mechanisms of oroxylin A in cancer therapy: Recent advances. · European journal of pharmacology
23.PMID: 37046789 (2023) — Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives. · Cancers
24.PMID: 40650064 (2025) — Pharmacological Evaluation of a Traditional Thai Polyherbal Formula for Alzheimer's Disease: Evidence from In Vitro and In Silico Studies. · International journal of molecular sciences
25.PMID: 38004136 (2023) — Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress. · Nutrients
26.PMID: 40833599 (2026) — Oroxin A suppresses non-small cell lung cancer via the HSP90AA1/AKT signaling pathway. · Naunyn-Schmiedeberg's archives of pharmacology
27.PMID: 41385833 (2026) — Chrysin promotes the survival of flaps through the TLR4/NF-κB/NLRP3 signaling pathway. · Burns : journal of the International Society for Burn Injuries
28.PMID: 40653321 (2025) — First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research. · Chinese journal of natural medicines
29.PMID: 28288320 (2017) — Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. · European journal of medicinal chemistry
30.PMID: 35298472 (2022) — Bioprospecting of fungal endophytes from Oroxylum indicum (L.) Kurz with antioxidant and cytotoxic activity. · PloS one