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PubMed · <i>Paeonia × suffruticosa</i> (Moutan Peony)-A Review of the Chemical Composition, Traditional and Professional Use in Medicine, Position in Cosmetics Industries, and Biotechnological Studies. (2022)
How does Paeonia suffruticosa work to reduce inflammation?
Paeonia suffruticosa contains active compounds, primarily paeonol and paeoniflorin, which exert anti-inflammatory and blood-moving effects. Paeonol inhibits pro-inflammatory mediators and reduces oxidative stress, while paeoniflorin modulates blood circulation and provides analgesic properties. In Traditional Chinese Medicine, the herb clears heat from the blood and invigorates circulation to disperse stasis. Evidence level: C, based on preliminary pharmacological studies.
Can I take Paeonia suffruticosa with blood thinners like warfarin?
No, Paeonia suffruticosa should not be combined with anticoagulant or antiplatelet medications. The herb has documented anticoagulant and blood-moving properties that may increase bleeding risk when taken with drugs like warfarin, aspirin, clopidogrel, or heparin. This interaction is clinically significant and potentially dangerous. Patients on blood-thinning medications should avoid this herb entirely and consult a qualified healthcare provider for alternatives.
What is the recommended dosage for Paeonia suffruticosa?
The typical adult dosage is 6-12 grams daily as a decoction or 300mg of standardized extract taken twice daily. Traditional Chinese Medicine practitioners often adjust doses based on individual diagnosis and the specific condition being treated. The herb is typically decocted by boiling in water for 20-30 minutes. Standardized extracts should specify paeonol or paeoniflorin content. Always follow professional guidance rather than self-prescribing.
Is Paeonia suffruticosa safe during pregnancy?
No, Paeonia suffruticosa is contraindicated during pregnancy and should be strictly avoided. The herb has blood-moving and stasis-dispersing properties that may stimulate uterine contractions and increase bleeding risk, potentially causing miscarriage. Traditional Chinese Medicine classifies it as unsafe for pregnant women. Women who are pregnant, trying to conceive, or breastfeeding should not use this herb without explicit guidance from a qualified healthcare practitioner.
What is Paeonia suffruticosa used for in Traditional Chinese Medicine?
Paeonia suffruticosa is used for conditions involving blood heat and blood stasis. Primary applications include menstrual disorders such as dysmenorrhea and amenorrhea, skin conditions with heat signs including rashes and inflammation, and menopausal hot flashes of the excess heat type. It also treats traumatic injuries with bruising and pain. Evidence level: C, based primarily on traditional use and preliminary research.
What are the side effects of Paeonia suffruticosa?
Common side effects include gastrointestinal discomfort such as nausea, stomach upset, or loose stools. Due to its blood-moving properties, it can increase menstrual flow, which may be problematic for those with heavy periods. The herb is contraindicated in deficiency cold patterns, where it may worsen symptoms like cold extremities, fatigue, and pale complexion. Discontinue use if adverse effects occur and consult a healthcare provider.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Paeonia suffruticosa, also known as tree peony or Moutan cortex, is a medicinal plant used in traditional oriental medicine for its anti-inflammatory, antioxidant, and cardioprotective properties [PMID:36501418, PMID:31030097].
Contexte
Paeonia suffruticosa Andrews is a medicinal peony species whose root bark (Moutan cortex) is a standard herbal medicine in China, Japan, and Korea [PMID:36822345, PMID:42123880]. It has been introduced into the European Pharmacopoeia Supplement 9.4 in 2018 [PMID:36501418].
Usages traditionnels
Historically, it has been used to treat female genital disorders, extravasated blood, cardiovascular issues, stagnant blood disorders [PMID:36822345], heart disease, menstrual irregularities, uterine fibroids, arthritis, and cough [PMID:30000962], and for addressing women's ailments by replenishing kidney Yin [PMID:38493906].
Composés actifs
Key bioactive compounds include paeonol, paeoniflorin, and 1,2,3,4,6-penta-O-galloyl-beta-D-glucose [PMID:36501418, PMID:22070681]. Other constituents include albiflorin, benzoylpaeoniflorin, liquiritin, flavonoids, proanthocyanidins, tannins, terpenoids, triterpenoids, complex polysaccharides [PMID:30000962], and alpha-linolenic acid [PMID:42123880]. Suffruticosol A is also isolated from this species [PMID:35852295].
Mécanisme d'action
Paeonol acts as a natural radical scavenger with antioxidant and anti-inflammatory effects [PMID:40124777]. It may modulate the GPR30 receptor to alleviate neuropsychiatric symptoms [PMID:38493906] and regulate the AMPK/Nrf2/GPX4 pathway to ameliorate chondrocyte ferroptosis [PMID:40124777]. Paeoniflorin may induce apoptosis and inhibit proliferation in tumors via NF-kappaB, Bcl-2, and MAPK signaling pathways [PMID:35279012]. Root extracts may regulate the IRS1/PI3K/FOXO pathway to ameliorate photoaging [PMID:40115263].
Preuves cliniques
Preuve CInflammation and Pain
Paeonol injections have been successfully applied in China for nearly 50 years for inflammation and pain-related indications [PMID:31030097].
Paeonol ameliorated anxiety, depression, and cognitive impairments in ovariectomized mice [PMID:38493906].
Preuve DOsteoblast Differentiation
Suffruticosol A increased osteogenic alkaline phosphatase activity and RUNX2 levels in pre-osteoblasts [PMID:35852295].
Sécurité et effets indésirables
The herb is generally well tolerated, though it can occasionally cause gastrointestinal upset and allergic skin reactions, particularly with topical application [PMID:30000962].
Grossesse et allaitement
Paeony may lower serum prolactin and potentially suppress lactation; therefore, it is probably best to avoid during breastfeeding [PMID:30000962]. No data exist on the safety and efficacy of peony in nursing mothers or infants [PMID:30000962].
Synthèse des preuves
Evidence consists primarily of review articles and preclinical animal or in vitro studies (Levels C and D). Clinical application of paeonol for inflammation is noted in China, but broader clinical trial data for other conditions are limited.
Sources PubMed
1.PMID: 30000962 (2006) — Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeonia suffruticosa (tree peony). · Phytochemistry
2.PMID: 36501418 (2022) — Paeonia × suffruticosa (Moutan Peony)-A Review of the Chemical Composition, Traditional and Professional Use in Medicine, Position in Cosmetics Industries, and Biotechnological Studies. · Plants (Basel, Switzerland)
3.PMID: 40115263 (2025) — Paeonia suffruticosa Andrews root extract ameliorates photoaging via regulating IRS1/PI3K/FOXO pathway. · Frontiers in pharmacology
4.PMID: 38493906 (2024) — Paeonol alleviates postmenopause-induced neuropsychiatric symptoms through the modulation of GPR30 in ovariectomized mice. · Journal of ethnopharmacology
5.PMID: 31030097 (2019) — Paeonol: pharmacological effects and mechanisms of action.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 40124777 (2025) — Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway. · Frontiers in pharmacology
7.PMID: 36822345 (2023) — Traditional uses, phytochemistry, pharmacology, and pharmacokinetics of the root bark of Paeonia x suffruticosa andrews: A comprehensive review. · Journal of ethnopharmacology
8.PMID: 22070681 (2011) — Polyphenols and neuroprotection against ischemia and neurodegeneration. · Mini reviews in medicinal chemistry
9.PMID: 42123880 (2026) — Pharmacological Effects and Development Prospects of the Main Active Compounds of Paeonia × suffruticosa Andrews in the Treatment of Panvascular Diseases. · Molecules (Basel, Switzerland)
10.PMID: 35852295 (2023) — Suffruticosol A elevates osteoblast differentiation targeting BMP2-Smad/1/5/8-RUNX2 in pre-osteoblasts. · BioFactors (Oxford, England)
11.PMID: 35279012 (2022) — The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
12.PMID: 34443563 (2021) — Biological Activities of Paeonol in Cardiovascular Diseases: A Review. · Molecules (Basel, Switzerland)