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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Paeonia veitchii is a medicinal herb from the Qinghai-Tibet Plateau used in traditional Chinese medicine, primarily as a source of red peony root (Paeoniae Radix Rubra) [PMID:36698081, PMID:38850115].
Contexte
Paeonia veitchii Lynch is a well-known herb from the Qinghai-Tibet Plateau south of the Himalayas [PMID:36698081]. Its dried root is one of the botanical origins of the traditional Chinese medicine known as Paeoniae Radix Rubra (Chishao) [PMID:38114171, PMID:39329953, PMID:40946821].
Usages traditionnels
It is traditionally employed to clear heat, cool the blood, dispel blood stasis, and alleviate pain [PMID:38850115, PMID:39329953]. It is also commonly used to treat heart disease, menstrual irregularities, uterine fibroids, arthritis, and cough, though data supporting these specific uses is poor [PMID:30000962].
Composés actifs
The roots contain monoterpene glycosides (including paeoniflorin, albiflorin, benzoylpaeoniflorin, and the new glycosides paeonidanin I, J, and K), polyphenols (such as 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose, gallic acid, and naringin), and paeonols (including paeonol and paeonoside) [PMID:22070681, PMID:27268664, PMID:30000962, PMID:33155408]. Other constituents include flavonoids, proanthocyanidins, tannins, terpenoids, triterpenoids, and complex polysaccharides [PMID:30000962].
Mécanisme d'action
Paeoniflorin may enhance tubular repair by promoting dihydroorotate dehydrogenase-dependent epithelial cell proliferation [PMID:41475629] and inhibit melanogenesis by regulating melanin-related signal transduction [PMID:37288793]. Albiflorin may alleviate liver injury by inactivating the P38MAPK/NF-κB signaling pathway [PMID:38381358]. The herb's polyphenols are described as neuroprotectants, antioxidants, anti-inflammatory, and antithrombic agents [PMID:22070681].
Preuves cliniques
Preuve DHyperuricemia
Paeonia veitchii extract demonstrated a uric acid-lowering effect through inhibition of xanthine oxidase and regulation of renal urate transporters in mice and liver cells [PMID:38176275]
Preuve DVascular occlusive diseases
Paeoniae Radix Rubra (including P. veitchii) dose-dependently enhanced endothelial cell proliferation and migration, suggesting pro-angiogenic potential via ADAM10-NOTCH and VEGFR2-PI3K/AKT signaling [PMID:40946821]
Preuve CLiver Diseases
Paeoniflorin demonstrates hepatic protection, cholestasis alleviation, and liver fibrosis attenuation via multiple pathways including TLR4-NF-κB and PI3K/Akt/Nrf2 [PMID:32410996]
Sécurité et effets indésirables
Paeonia is generally well tolerated, but can occasionally cause gastrointestinal upset and allergic skin reactions, particularly when applied topically [PMID:30000962].
Grossesse et allaitement
Paeony can lower serum prolactin, which might suppress lactation; therefore, it is probably best to avoid during breastfeeding [PMID:30000962]. No data exist on the safety and efficacy of peony in nursing mothers or infants [PMID:30000962].
Synthèse des preuves
The evidence consists primarily of laboratory-based studies (cell cultures and animal models) and pharmacological reviews. There is a lack of high-level clinical trial data specifically for Paeonia veitchii, although some clinical data exists for the broader category of red peony root (Paeoniae Radix Rubra).
Sources PubMed
1.PMID: 30000962 (2006) — A Pharmacological Review of Bioactive Constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch. · Phytotherapy research : PTR
2.PMID: 27268664 (2017) — Monoterpene glycosides from Paeonia veitchii. · Journal of Asian natural products research
3.PMID: 36698081 (2023) — Illuminating the biosynthesis pathway genes involved in bioactive specific monoterpene glycosides in Paeonia veitchii Lynch by a combination of sequencing platforms. · BMC genomics
4.PMID: 22070681 (2011) — Polyphenols and neuroprotection against ischemia and neurodegeneration. · Mini reviews in medicinal chemistry
5.PMID: 38114171 (2023) — [Selection and validation of reference genes for quantitative real-time PCR analysis in Paeonia veitchii].
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
· Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
6.PMID: 30144752 (2018) — Advancement in the chemical analysis of Paeoniae Radix (Shaoyao). · Journal of pharmaceutical and biomedical analysis
7.PMID: 38133706 (2024) — Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs. · Journal of natural medicines
8.PMID: 32371143 (2020) — Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action. · Journal of ethnopharmacology
9.PMID: 40946821 (2026) — Network pharmacology and molecular docking reveal the multi-target mechanisms of Paeoniae Radix Rubra in functional angiogenesis: Synergistic regulation of ADAM10-NOTCH and VEGFR2-PI3K/AKT signaling. · Journal of ethnopharmacology
10.PMID: 39329953 (2024) — Progress in the Study of Chemical Structure and Pharmacological Effects of Total Paeony Glycosides Isolated from Radix Paeoniae Rubra. · Current issues in molecular biology
11.PMID: 33155408 (2020) — New Insights into the Impact of Ecological Factor on Bioactivities and Phytochemical Composition of Paeonia veitchii. · Chemistry & biodiversity
12.PMID: 32410996 (2020) — Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases-A Mini Review. · Frontiers in pharmacology
13.PMID: 38176275 (2024) — Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters. · Phytomedicine : international journal of phytotherapy and phytopharmacology
14.PMID: 38850115 (2024) — Paeoniae Radix Rubra: A Review of Ethnopharmacology, Phytochemistry, Pharmacological Activities, Therapeutic Mechanism for Blood Stasis Syndrome, and Quality Control. · Chemistry & biodiversity
15.PMID: 41475629 (2026) — Paeoniflorin enhances tubular repair by promoting dihydroorotate dehydrogenase-dependent epithelial cell proliferation in cisplatin-induced chronic kidney disease. · Journal of ethnopharmacology
16.PMID: 37288793 (2023) — Paeoniflorin found in Paeonia lactiflora root extract inhibits melanogenesis by regulating melanin-related signal transduction in B16F10 cells. · Journal of cosmetic dermatology
17.PMID: 38381358 (2024) — Albiflorin Alleviates Severe Acute Pancreatitis-Associated Liver Injury by Inactivating P38MAPK/NF-κB Signaling Pathway. · Biochemical genetics