Pellitory Spanish (Anacyclus pyrethrum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Spanish Pellitory work for toothache relief?

Spanish Pellitory contains pyrethrin and pellitorine, which stimulate sensory nerve endings and increase local blood flow. These compounds act as counter-irritants, creating a warming sensation that can temporarily distract from deeper dental pain. The herb also functions as a sialagogue, stimulating salivation which may help cleanse the oral cavity. Evidence Level: C/Traditional.

Is Spanish Pellitory safe to take during pregnancy?

Spanish Pellitory is contraindicated in pregnancy and should be avoided. The pyrethrin compounds may stimulate uterine contractions and cause significant irritation to mucous membranes. There is insufficient safety data for use during breastfeeding, so it should also be avoided while nursing. Women who are pregnant or trying to conceive should consult a healthcare provider before using any herbal preparations. Evidence Level: C.

What is the recommended dosage for Spanish Pellitory root?

For dental pain, Spanish Pellitory root tincture is typically applied topically to the affected tooth or gum area using a cotton applicator. For internal use as a sialagogue, the traditional adult dosage is 0.5-1ml of tincture. Due to its intensely pungent properties and potential to cause burning sensations, internal use should be supervised by a qualified herbalist. Evidence Level: C/Traditional.

Does Spanish Pellitory interact with any medications?

Limited clinical data exists on drug interactions for Spanish Pellitory. Due to its effects on salivation and potential for gastrointestinal irritation, it may theoretically interact with anticholinergic medications or drugs affecting digestive function. Individuals with inflammatory gastrointestinal conditions should avoid internal use. Always consult a healthcare provider before combining herbal remedies with prescription medications. Evidence Level: C.

What are the side effects of Spanish Pellitory?

Spanish Pellitory commonly causes an intense burning sensation in the mouth and throat due to its pyrethrin content. Excessive salivation is another frequent side effect when taken internally. Topical application may cause local skin irritation in sensitive individuals. People with inflammatory gastrointestinal conditions, such as gastritis or ulcers, should avoid internal use as it may aggravate symptoms. Evidence Level: C.

What is Spanish Pellitory used for in herbal medicine?

Spanish Pellitory is traditionally used for toothache, facial paralysis, and stimulating salivation. In Unani and Berber medicine, it has been employed as a dental analgesic and for rheumatic conditions. The root's intensely pungent properties make it useful as a sialagogue and counter-irritant for localized pain. Current clinical evidence supporting these traditional uses is limited. Evidence Level: C/Traditional.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 29 articles PubMed · modèle : gemma4:31b

Résumé

Anacyclus pyrethrum is an annual medicinal herb used in traditional North African and Indian medicine, recognized for its antioxidant, anti-inflammatory, and antimicrobial properties [PMID:36235444, PMID:33776312].

Contexte

Anacyclus pyrethrum (L.) is an endemic and endangered medicinal species found in Morocco and Algeria [PMID:36235444, PMID:36079684]. It exists in varieties such as A. pyrethrum var. pyrethrum and A. pyrethrum var. depressus [PMID:37513251].

Usages traditionnels

It has been used in traditional North African and Indian medicine to treat cancer, rheumatism, epilepsy, diabetes, Alzheimer's disease, and inflammatory and painful diseases [PMID:33776312, PMID:28928658].

Composés actifs

The plant contains alkaloids (including pellitorin, pyracyclumines, and anacyquinolines), n-alkylamides, pyrethrins, sesamin, and essential oils [PMID:36235444, PMID:38692343, PMID:29775308, PMID:23047251]. The essential oil of the leaves is primarily composed of santolina alcohol (40.7%) and germacrene-D (8.9%) [PMID:39220961].

Mécanisme d'action

Active components such as anacyquinoline G and H inhibit nitric oxide (NO) production [PMID:38692343, PMID:39216630]. Ethanol extracts of the root may suppress the expression of TLR4 and NF-κB p65, thereby alleviating Th2 skewing and increasing Th1 response [PMID:36990039].

Preuves cliniques

Preuve DMale Infertility (Cadmium-induced)

Anacyclus pyrethrum extract (100mg/kg) protected male rats against cadmium reproductive toxicity and improved sperm functions [PMID:39604977]

Preuve DEpilepsy (Kainic acid-induced)

Aqueous and methanolic extracts of the root demonstrated anticonvulsive and neuroprotective effects in mice [PMID:31710948]

Preuve DParkinson's Disease-MCI

Ethanol extracts of the root (EEAP) showed potential effectiveness in treating a mouse model of PD-MCI [PMID:40253741]

Preuve DOpioid Addiction (Fentanyl withdrawal)

Aqueous extract of A. pyrethrum was investigated for its potential to mitigate adverse effects of Fentanyl withdrawal in a mouse model [PMID:38927359]

Preuve DCough-Variant Asthma (CVA)

Ethanol extract of the root reduced cough frequency, inflammatory effects, and oxidative stress in a rat model [PMID:37910337]

Preuve DBacterial Infection (E. coli)

Sécurité et effets indésirables

Acute toxicity studies in Swiss mice using hydroethanolic extracts of roots, seeds, leaves, and capitula at doses up to 2000 mg/kg induced no signs of toxicity or mortality [PMID:33776312].

Synthèse des preuves

The majority of evidence is derived from in vitro assays and animal models (Level D), with some systematic reviews (Level C) summarizing its general pharmacological potential. No human clinical trials were provided in the abstracts.

Sources PubMed

1.PMID: 30000694 (2006) — Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. · Annual review of entomology
2.PMID: 38692343 (2024) — Alkaloid constituents from Anacyclus pyrethrum. · Phytochemistry
3.PMID: 19445766 (2009) — Head lice. · BMJ clinical evidence
4.PMID: 40253741 (2025) — Integrated network pharmacology, metabolomics, and microbiome studies to reveal the therapeutic effects of Anacyclus pyrethrum in PD-MCI mice. · Phytomedicine : international journal of phytotherapy and phytopharmacology
5.PMID: 39216630 (2025) — Alkaloids from Anacyclus pyrethrum. · Phytochemistry
6.

Pellitory Spanish

Sources et citations

Calculer une dose sûre de Pellitory Spanish

Kunzea Ambigua

Chapéu de Couro

Angelica dahurica

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Pellitory Spanish

Sources et citations

Calculer une dose sûre de Pellitory Spanish

Plantes associées

Kunzea Ambigua

Chapéu de Couro

Angelica dahurica

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales