Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Hedeoma pulegioides
North American mint-family herb with similar uses to European pennyroyal; used by Indigenous peoples as insect repellent and digestive herb.
Pennyroyal American (Hedeoma pulegioides) is a North American mint species traditionally used by Indigenous peoples as an insect repellent and digestive aid. Its primary active compound, pulegone, is a potent hepatotoxin and abortifacient, limiting modern use to topical application only. Despite historical use for headaches and menstrual regulation, the herb's significant toxicity contraindicates internal consumption.
Pulegone undergoes hepatic CYP450-mediated metabolism to reactive metabolites, including menthofuran, which deplete glutathione and cause centrilobular hepatic necrosis. The compound also exhibits GABA-A receptor antagonism, potentially explaining the convulsant effects observed in overdose. Additionally, pulegone stimulates uterine smooth muscle contraction via prostaglandin synthesis modulation, contributing to its emmenagogue and abortifacient properties.
North American mint-family herb with similar uses to European pennyroyal; used by Indigenous peoples as insect repellent and digestive herb.
Pennyroyal American (Hedeoma pulegioides) is a North American mint species traditionally used by Indigenous peoples as an insect repellent and digestive aid. Its primary active compound, pulegone, is a potent hepatotoxin and abortifacient, limiting modern use to topical application only. Despite historical use for headaches and menstrual regulation, the herb's significant toxicity contraindicates internal consumption.
Pulegone undergoes hepatic CYP450-mediated metabolism to reactive metabolites, including menthofuran, which deplete glutathione and cause centrilobular hepatic necrosis. The compound also exhibits GABA-A receptor antagonism, potentially explaining the convulsant effects observed in overdose. Additionally, pulegone stimulates uterine smooth muscle contraction via prostaglandin synthesis modulation, contributing to its emmenagogue and abortifacient properties.