Phaseolus vulgaris (Phaseolus vulgaris): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Phaseolus vulgaris work for weight loss?

Phaseolus vulgaris works through its active compound, phaseolamin, which acts as an alpha-amylase inhibitor. This mechanism prevents the enzyme alpha-amylase from breaking down dietary starches into absorbable sugars (Evidence Level C). By blocking this digestion process, the body excrets a portion of consumed carbohydrates undigested, reducing overall caloric intake. This 'carb blocking' action is the primary reason it is used for weight management.

Does white kidney bean extract interact with diabetes medications?

While direct clinical interactions are not well-documented, Phaseolus vulgaris extracts may lower postprandial blood glucose by inhibiting starch absorption. This effect could theoretically enhance the blood-sugar-lowering effects of diabetes medications like insulin or metformin, potentially causing hypoglycemia (Evidence Level C). Individuals on antidiabetic medications should monitor blood sugar levels closely and consult a physician before adding this supplement to their regimen.

What is the recommended dosage for Phaseolus vulgaris extract?

For weight management, clinical trials typically utilize white kidney bean extract dosages ranging from 445 mg to 1500 mg daily (Evidence Level C). This dose should be taken immediately before or during meals containing complex carbohydrates to maximize the starch-blocking effect. As a food, beans are consumed freely, but raw beans are toxic and must be cooked to neutralize harmful lectins.

Is Phaseolus vulgaris safe during pregnancy?

Phaseolus vulgaris is considered safe during pregnancy when consumed as a thoroughly cooked food, offering protein, fiber, and essential vitamins. However, there is insufficient safety data regarding the use of concentrated white kidney bean extract supplements during pregnancy (Evidence Level C). Pregnant women should rely on dietary intake of cooked beans and consult a healthcare provider before using supplements for weight management.

What are the side effects of white kidney bean extract?

The most common side effects of white kidney bean extract are gastrointestinal, including bloating, flatulence, and stomach cramping (Evidence Level C). These occur because undigested starch ferments in the colon. Severe toxicity, including nausea and vomiting, arises from eating raw beans due to toxic lectins (phaseolus lectins). Proper cooking destroys these lectins, making the beans safe for consumption.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Phaseolus vulgaris, commonly known as the common or kidney bean, is a globally cultivated legume serving as a significant source of dietary protein and calories [PMID:39459901, PMID:33282144]. Certain extracts are utilized as nutraceuticals for weight management via the inhibition of alpha-amylase [PMID:38830962, PMID:35485365].

Contexte

Phaseolus vulgaris is a legume indigenous to the Americas and is now cultivated on all continents [PMID:32314065]. It is a major crop used for human nutrition, particularly as a protein source in developing countries [PMID:39459901, PMID:35540177].

Composés actifs

The herb contains proteins, carbohydrates, dietary fiber, and bioactive compounds such as anthocyanins, polyphenols, and flavonoids (e.g., quercetin), particularly in black bean varieties [PMID:37999428, PMID:28817105]. It also contains antinutrients including saponins, tannins, phytic acid, gossypol, and lectins [PMID:37999428].

Mécanisme d'action

Protein-based alpha-amylase inhibitors (α-AIs) in Phaseolus vulgaris reduce the activity of alpha-amylase through protein-protein interaction, which decreases the absorption rate of complex carbohydrates and reduces calorie intake [PMID:35485365, PMID:38830962].

Preuves cliniques

Preuve BOverweight and moderate obesity

A proprietary aqueous extract (Phase 2 WKBE) significantly reduced body weight, fat mass, BMI, and waist and hip circumference in a dose-dependent manner over 12 weeks [PMID:38830962].

Preuve CObesity and metabolic health

Clinical and preclinical evidence suggests potential for weight regulation, suppression of starch digestion, attenuation of postprandial glycemia, and hypolipidemic effects [PMID:41300098].

Sécurité et effets indésirables

Toxicity can be caused by lectins, saponins, phytates, and protease inhibitors, or through allergenicity induced by allergenic proteins [PMID:23410632]. Consumption may also lead to digestive system ailments and flatulence due to antinutrient content and oligosaccharides [PMID:37999428, PMID:32851056].

Posologie et administration

In one clinical trial, doses of 700 mg or 1000 mg of a proprietary aqueous extract were administered three times a day, 30 minutes before meals, for 12 weeks [PMID:38830962]. No PubMed data available. Consult a healthcare provider.

Synthèse des preuves

Evidence for weight loss is supported by one randomized controlled trial (Level B) and narrative reviews (Level C). Safety data regarding toxicity and antinutrients are provided in review formats (Level C).

Sources PubMed

1.PMID: 38830962 (2024) — Proprietary alpha-amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial. · Scientific reports
2.PMID: 39459901 (2024) — Interactions between Common Bean Viruses and Their Whitefly Vector. · Viruses
3.PMID: 33282144 (2017) — Viruses infecting common bean (Phaseolus vulgaris L.) in Tanzania: A review on molecular characterization, detection and disease management options. · African journal of agricultural research
4.PMID: 32314065 (2020) — The promiscuity of Phaseolus vulgaris L. (common bean) for nodulation with rhizobia: a review. · World journal of microbiology & biotechnology
5.PMID: 35485365 (2022) — Common bean (Phaseolus vulgaris L.) α-amylase inhibitors as safe nutraceutical strategy against diabetes and obesity: An update review.

Phaseolus vulgaris

Sources et citations

Calculer une dose sûre de Phaseolus vulgaris