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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Picrasma excelsa
Caribbean and South American tree with intensely bitter wood used as a tonic digestive and antimalarial; one of the most bitter known plants.
Picrasma excelsa, a Caribbean and South American tree, yields intensely bitter wood used traditionally as a digestive tonic and antimalarial. Its primary active compounds include quassinoids (quassin, neoquassin, isoquassin, 18-hydroxyquassin) and beta-carboline alkaloids, which contribute to its bitter taste and pharmacological effects. Modern research supports its use for antimalarial, digestive stimulant, and antiparasitic applications, though evidence is limited to preliminary studies.
Quassinoids from Picrasma excelsa activate bitter taste receptors (TAS2Rs) in the oral cavity and gastrointestinal tract, stimulating gastric acid secretion, bile flow, and digestive enzyme release via vagal reflexes. Additionally, quassinoids inhibit protein synthesis in Plasmodium species by binding to the 80S ribosome, exerting antimalarial effects. They also suppress NF-κB signaling, contributing to anti-inflammatory and antiparasitic actions. Beta-carboline alkaloids may inhibit monoamine oxidase (MAO) and interact with GABA receptors, potentially affecting mood and appetite.
Caribbean and South American tree with intensely bitter wood used as a tonic digestive and antimalarial; one of the most bitter known plants.
Picrasma excelsa, a Caribbean and South American tree, yields intensely bitter wood used traditionally as a digestive tonic and antimalarial. Its primary active compounds include quassinoids (quassin, neoquassin, isoquassin, 18-hydroxyquassin) and beta-carboline alkaloids, which contribute to its bitter taste and pharmacological effects. Modern research supports its use for antimalarial, digestive stimulant, and antiparasitic applications, though evidence is limited to preliminary studies.
Quassinoids from Picrasma excelsa activate bitter taste receptors (TAS2Rs) in the oral cavity and gastrointestinal tract, stimulating gastric acid secretion, bile flow, and digestive enzyme release via vagal reflexes. Additionally, quassinoids inhibit protein synthesis in Plasmodium species by binding to the 80S ribosome, exerting antimalarial effects. They also suppress NF-κB signaling, contributing to anti-inflammatory and antiparasitic actions. Beta-carboline alkaloids may inhibit monoamine oxidase (MAO) and interact with GABA receptors, potentially affecting mood and appetite.