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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Piper retrofractum
Indonesian medicinal pepper used in Jamu traditional medicine; similar to Indian long pepper.
Piper retrofractum, also known as Javanese long pepper, is a medicinal herb central to Indonesian Jamu traditional medicine, valued for its anti-inflammatory, antimicrobial, and bioavailability-enhancing properties. Its primary active compounds include piperine, retrofractamides A and B, and guineensine, which contribute to its diverse therapeutic effects. Modern research supports its use for digestive and respiratory conditions, though evidence remains limited (Level C).
Piperine, the major alkaloid, enhances bioavailability by inhibiting CYP3A4 and P-glycoprotein, thereby increasing absorption of co-administered drugs. It also activates TRPV1 receptors, contributing to thermogenic and analgesic effects, while retrofractamides exhibit antimicrobial activity through membrane disruption. Anti-inflammatory actions are mediated via suppression of COX-2, LOX, and NF-κB pathways, reducing pro-inflammatory cytokine production.
Indonesian medicinal pepper used in Jamu traditional medicine; similar to Indian long pepper.
Piper retrofractum, also known as Javanese long pepper, is a medicinal herb central to Indonesian Jamu traditional medicine, valued for its anti-inflammatory, antimicrobial, and bioavailability-enhancing properties. Its primary active compounds include piperine, retrofractamides A and B, and guineensine, which contribute to its diverse therapeutic effects. Modern research supports its use for digestive and respiratory conditions, though evidence remains limited (Level C).
Piperine, the major alkaloid, enhances bioavailability by inhibiting CYP3A4 and P-glycoprotein, thereby increasing absorption of co-administered drugs. It also activates TRPV1 receptors, contributing to thermogenic and analgesic effects, while retrofractamides exhibit antimicrobial activity through membrane disruption. Anti-inflammatory actions are mediated via suppression of COX-2, LOX, and NF-κB pathways, reducing pro-inflammatory cytokine production.