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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Sinopodophyllum hexandrum
Himalayan mayapple used in Ayurveda and Unani medicine as purgative and source of podophyllotoxin for cancer treatment.
Podophyllum hexandrum (Himalayan mayapple) is a potent medicinal plant used traditionally as a cathartic purgative and modernly as a source of podophyllotoxin, a lignan with antimitotic activity used in cancer chemotherapy. Its primary active compounds include podophyllotoxin, alpha-peltatin, beta-peltatin, and 4-demethylpodophyllotoxin, which inhibit microtubule assembly and topoisomerase II.
Podophyllotoxin binds to tubulin, preventing microtubule polymerization and arresting cells in metaphase, similar to colchicine. Its semisynthetic derivatives (e.g., etoposide) inhibit topoisomerase II, causing DNA strand breaks. The compound also inhibits nucleoside transport and induces apoptosis via mitochondrial pathways. Purgative action is due to irritation of intestinal mucosa, increasing peristalsis.
Himalayan mayapple used in Ayurveda and Unani medicine as purgative and source of podophyllotoxin for cancer treatment.
Podophyllum hexandrum (Himalayan mayapple) is a potent medicinal plant used traditionally as a cathartic purgative and modernly as a source of podophyllotoxin, a lignan with antimitotic activity used in cancer chemotherapy. Its primary active compounds include podophyllotoxin, alpha-peltatin, beta-peltatin, and 4-demethylpodophyllotoxin, which inhibit microtubule assembly and topoisomerase II.
Podophyllotoxin binds to tubulin, preventing microtubule polymerization and arresting cells in metaphase, similar to colchicine. Its semisynthetic derivatives (e.g., etoposide) inhibit topoisomerase II, causing DNA strand breaks. The compound also inhibits nucleoside transport and induces apoptosis via mitochondrial pathways. Purgative action is due to irritation of intestinal mucosa, increasing peristalsis.