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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Podophyllum peltatum
Eastern North American woodland plant used by Native peoples as a cathartic and topically for warts; source of podophyllin.
Podophyllum peltatum (mayapple) is a North American woodland plant historically used by Native Americans as a cathartic and topical wart treatment. Its primary active compound, podophyllotoxin, is a potent antimitotic agent that disrupts microtubule formation, and it serves as a precursor for semisynthetic anticancer drugs like etoposide. Modern uses are limited to topical application for genital warts under strict medical supervision due to severe systemic toxicity.
Podophyllotoxin binds to tubulin, inhibiting microtubule polymerization and arresting cell division in metaphase, which accounts for its antimitotic and antitumor activity. Topically, it causes necrosis of wart tissue by disrupting cellular microtubules and inducing apoptosis. The compound also inhibits topoisomerase II (via its semisynthetic derivatives), leading to DNA damage in rapidly dividing cells. Systemic absorption can cause severe neurotoxicity and gastrointestinal effects due to its potent cytotoxic action.
Eastern North American woodland plant used by Native peoples as a cathartic and topically for warts; source of podophyllin.
Podophyllum peltatum (mayapple) is a North American woodland plant historically used by Native Americans as a cathartic and topical wart treatment. Its primary active compound, podophyllotoxin, is a potent antimitotic agent that disrupts microtubule formation, and it serves as a precursor for semisynthetic anticancer drugs like etoposide. Modern uses are limited to topical application for genital warts under strict medical supervision due to severe systemic toxicity.
Podophyllotoxin binds to tubulin, inhibiting microtubule polymerization and arresting cell division in metaphase, which accounts for its antimitotic and antitumor activity. Topically, it causes necrosis of wart tissue by disrupting cellular microtubules and inducing apoptosis. The compound also inhibits topoisomerase II (via its semisynthetic derivatives), leading to DNA damage in rapidly dividing cells. Systemic absorption can cause severe neurotoxicity and gastrointestinal effects due to its potent cytotoxic action.