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Propolis exerts antimicrobial activity through multiple mechanisms. Its active compounds—particularly flavonoids (pinocembrin), phenolic acids, and CAPE (caffeic acid phenethyl ester)—disrupt bacterial cell membranes, inhibit bacterial enzyme function, and prevent bacterial adherence to host tissues. These compounds also demonstrate antiviral properties by blocking viral entry into cells and inhibiting viral replication. Additionally, propolis modulates immune function by enhancing macrophage activity and reducing inflammatory cytokines. Evidence Level: C (preclinical and observational studies support these mechanisms, though robust clinical trials remain limited).
Can I take propolis with blood thinners like warfarin?
Propolis may interact with anticoagulant medications such as warfarin, potentially increasing bleeding risk. Some constituents in propolis, particularly flavonoids, may inhibit platelet aggregation and enhance anticoagulant effects. Patients taking blood thinners, antiplatelet drugs, or NSAIDs should consult a healthcare provider before using propolis supplements. This interaction is theoretical but clinically significant given propolis's documented effects on blood clotting factors. Evidence Level: C. Discontinue propolis at least two weeks before scheduled surgery to minimize bleeding complications.
What is the recommended dosage of propolis for adults?
The typical adult dosage of propolis is 500-1000mg of standardized extract daily, or 10-20 drops of tincture taken internally. For topical applications on wounds or cold sores, a 5-10% propolis preparation can be applied 2-3 times daily. For sore throat relief, propolis throat sprays or lozenges may be used every 2-3 hours as needed. Dosage may vary based on the specific formulation and concentration. Evidence Level: C. Always follow product label instructions and consult a healthcare provider for personalized dosing recommendations.
Is propolis safe during pregnancy and breastfeeding?
Propolis is generally considered safe during pregnancy and breastfeeding when used at recommended doses. No significant adverse effects have been reported in pregnant or nursing women in available studies. However, women with a history of bee or honey allergies should avoid propolis entirely, as allergic reactions could potentially harm both mother and baby. Evidence Level: C. As with any supplement during pregnancy, consult a qualified healthcare provider before use to ensure safety for your individual circumstances.
What are the side effects and allergic reactions to propolis?
Propolis is well-tolerated by most people, but allergic reactions can occur, particularly in individuals sensitive to bee products. Common side effects include contact dermatitis (skin rash), mouth irritation, and mild gastrointestinal upset. More severe allergic reactions—such as swelling, difficulty breathing, or anaphylaxis—are rare but possible, especially in those with asthma or bee allergies. Evidence Level: C. Discontinue use immediately if any allergic symptoms develop. People with known bee, honey, or pollen allergies should avoid propolis entirely.
What is propolis most commonly used for?
Propolis is traditionally used for sore throat relief, wound healing, dental health, cold sore treatment, and supporting immune function against infections. Research suggests antimicrobial activity against bacteria, viruses, and fungi, making it useful for oral health (gingivitis, plaque reduction) and topical wound care. Some evidence supports its use for recurrent cold sores (herpes labialis) and upper respiratory infections. Evidence Level: C (preliminary clinical evidence; more rigorous trials needed). Propolis should complement, not replace, conventional medical treatments for serious infections.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Propolis, also known as "bee glue," is a resinous substance produced by honeybees (Apis mellifera) that exhibits a broad spectrum of biological activities, including antimicrobial, antioxidant, and anti-inflammatory effects [PMID:33100868, PMID:36028892].
Contexte
Propolis is a complex, waxy resinous material produced by honeybees (Apis mellifera) by mixing plant exudates—such as tree buds, sap flows, leaves, branches, and barks—with beeswax and bee secretions [PMID:36079680, PMID:33100868]. Bees use it as a building material to seal cracks, repair combs, and as a defensive substance to protect the hive from microbial infections and decomposition of intruders [PMID:30053651, PMID:31762646, PMID:34444688]. Its composition varies significantly based on geographical location, climatic zone, honeybee species, and local flora [PMID:36079680, PMID:34444688, PMID:35883906].
Usages traditionnels
Propolis has been used in folk and traditional medicine for centuries globally to treat purulent disorders, improve wound healing, and as a general remedy for improving health and treating various diseases [PMID:36028892, PMID:31648904, PMID:32679731].
Composés actifs
Propolis contains a complex mixture of over 300 compounds, including resins, waxes, polyphenols, flavonoids, polysaccharides, volatile materials, aromatic acids, essential oils, amino acids, and steroids [PMID:33100868, PMID:31762646, PMID:16629510]. Specific bioactive constituents include caffeic acid phenethyl ester (CAPE), artepillin C, chrysin, nemorosone, galangin, and cardanol [PMID:35754701, PMID:25723108].
Mécanisme d'action
Antimicrobial activity is possibly attributable to high flavonoid content [PMID:2182860]. In the context of cancer, mechanisms include the inhibition of matrix metalloproteinases, anti-angiogenesis, prevention of metastasis, cell-cycle arrest, and induction of apoptosis [PMID:25723108]. Against Leishmania, it inhibits promastigote proliferation and produces anti-inflammatory effects by inhibiting nitric oxide (NO) production while increasing macrophage activation and production of TLR-2, TNF-α, IL-4, and IL-17 [PMID:32691360].
Preuves cliniques
Preuve CBacterial Infections
Propolis demonstrates a broad spectrum of antibacterial activity, particularly against Gram-positive bacteria (such as Staphylococcus aureus and human tubercle bacillus), with more limited activity against Gram-negative bacilli [PMID:33100868, PMID:2182860, PMID:37372501]. It has been noted to enhance the efficacy of conventional antibiotics [PMID:33100868].
Preuve CProtozoan Parasitic Infections
Propolis inhibits parasitemia in Plasmodium and Trypanosoma and inhibits the proliferation of promastigotes in Leishmania [PMID:32691360].
Preuve CCancer
Propolis and its constituents (CAPE, artepillin C, chrysin) show efficacy against various cancers, including brain, breast, liver, prostate, and colon cancers, through apoptotic events and mitochondrial membrane depolarization [PMID:25723108, PMID:34603594].
Preuve CMild Cognitive Impairment
Brazilian green propolis improves cognitive functions in patients with mild cognitive impairments living at high altitude via antioxidant properties [PMID:34444688].
Sécurité et effets indésirables
Propolis is generally considered relatively non-toxic, with a no-effect level (NOEL) of 1400 mg/kg body weight/day in a 90-mouse study [PMID:9651052]. However, allergic reactions are not uncommon [PMID:9651052], and there have been reports of propolis-induced erythema multiforme [PMID:33757675] and an increased prevalence of positive patch test reactions [PMID:40111761].
Synthèse des preuves
The evidence is primarily based on review articles and in vitro/in vivo preclinical studies (Level C and D), indicating strong potential for antimicrobial and anticancer activity, though large-scale human clinical trials are not detailed in the provided abstracts.
Sources PubMed
1.PMID: 30053651 (2018) — The phytochemistry of the honeybee. · Phytochemistry
2.PMID: 36079680 (2022) — Plants: Sources of Diversity in Propolis Properties. · Plants (Basel, Switzerland)
3.PMID: 33757675 (2021) — Bee propolis-induced erythema multiforme. · Journal of the Formosan Medical Association = Taiwan yi zhi
4.PMID: 33100868 (2020) — Propolis as a novel antibacterial agent. · Saudi journal of biological sciences
5.PMID: 2182860 (1990) — Antibacterial properties of propolis (bee glue). · Journal of the Royal Society of Medicine
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
9.PMID: 31762646 (2019) — Composition and functional properties of propolis (bee glue): A review. · Saudi journal of biological sciences
10.PMID: 34444688 (2021) — Experimental Evidence for Therapeutic Potentials of Propolis. · Nutrients
11.PMID: 19554760 (2009) — Effects of stingless bee and honey bee propolis on four species of bacteria. · Genetics and molecular research : GMR
12.PMID: 36028892 (2022) — Propolis: An update on its chemistry and pharmacological applications. · Chinese medicine
13.PMID: 34611369 (2021) — How diverse is the chemistry and plant origin of Brazilian propolis? · Apidologie
14.PMID: 33593461 (2021) — The effects of crude propolis, its volatiles and ethanolic extracts on the ecto-parasitic mite, Varroa destructor and health of the African savannah honey bee, Apis mellifera scutellata. · Parasitology
15.PMID: 35911197 (2022) — Phytochemical composition and bio-functional properties of Apis mellifera propolis from Kenya. · Royal Society open science
16.PMID: 35754701 (2022) — An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms. · Evidence-based complementary and alternative medicine : eCAM
17.PMID: 31648904 (2021) — Propolis of stingless bees: A phytochemist's guide through the jungle of tropical biodiversity. · Phytomedicine : international journal of phytotherapy and phytopharmacology
18.PMID: 25723108 (2016) — Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. · Journal of dietary supplements
19.PMID: 34603594 (2021) — Stingless Bee Propolis: New Insights for Anticancer Drugs. · Oxidative medicine and cellular longevity
20.PMID: 34832943 (2021) — Use of Stingless Bee Propolis and Geopropolis against Cancer-A Literature Review of Preclinical Studies. · Pharmaceuticals (Basel, Switzerland)
21.PMID: 32679731 (2020) — Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components. · International journal of molecular sciences
22.PMID: 34742143 (2022) — Anti-fungal and antioxidant properties of propolis (bee glue) extracts. · International journal of food microbiology
23.PMID: 35883906 (2022) — Chemical Profiling, Antioxidant, and Antimicrobial Activity of Saudi Propolis Collected by Arabian Honey Bee (Apis mellifera jemenitica) Colonies. · Antioxidants (Basel, Switzerland)
24.PMID: 27069724 (2016) — Drug leads agents from methanol extract of Nigerian bee (Apis mellifera) propolis. · Journal of intercultural ethnopharmacology
25.PMID: 9651052 (1998) — Review of the biological properties and toxicity of bee propolis (propolis). · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
26.PMID: 30347819 (2018) — Cytoprotective Effects of Natural Compounds against Oxidative Stress. · Antioxidants (Basel, Switzerland)
27.PMID: 36829972 (2023) — Honey's Antioxidant and Antimicrobial Properties: A Bibliometric Study. · Antioxidants (Basel, Switzerland)
28.PMID: 16629510 (2006) — Biological activity of bee propolis in health and disease. · Asian Pacific journal of cancer prevention : APJCP
29.PMID: 40906303 (2025) — Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy. · Natural products and bioprospecting