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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Protium heptaphyllum is a South American tree of the Burseraceae family known for producing a resin with diverse pharmacological activities, including anti-inflammatory and analgesic effects [PMID:30003594, 33800018].
Contexte
Protium heptaphyllum (also known as 'almecegueira', 'almacega', or 'white pitch') is a tree native to the tropical regions of South America, particularly Brazil's Atlantic Forest [PMID:30003594, 33800018, 42026118]. It produces an amorphous resin and essential oils used in various applications [PMID:30003594, 28143669].
Usages traditionnels
In Brazilian folk medicine, it is used to treat inflammatory conditions, hasten wound repair, and as an analgesic [PMID:30499330, 39056728, 14643690]. In quilombola communities, the resin is burned as incense to treat headaches via inhalation of the smoke [PMID:33932517].
Composés actifs
The resin contains a mixture of alpha- and beta-amyrin, taraxastan-3-oxo-20-ol, and sitostenonein [PMID:30003594, 11543977]. Essential oils are rich in volatile monoterpenes, including terpinolene, p-cymene, p-cymen-8-ol, myrcene, alpha-pinene, and beta-phellandrene [PMID:28143669, 30499330, 37667500, 31780877]. The plant is also noted for its richness in flavonoids and terpenes [PMID:39452080].
Mécanisme d'action
The alpha- and beta-amyrin mixture may act via a naloxone-reversible manner and is associated with the TRPV1 antagonist pathway in visceral nociception [PMID:16450293]. In hepatocytes, the gum resin extract regulates proteins involved in cholesterol metabolism, including HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR [PMID:33800828]. Essential oils may disrupt bacterial cell membranes, leading to the leakage of intracellular constituents [PMID:31780877]. Alpha- and beta-amyrin have also demonstrated the ability to inhibit the NorA efflux protein in certain bacterial strains [PMID:34528866].
Preuves cliniques
Preuve DVisceral Nociception
Alpha- and beta-amyrin showed dose-related significant antinociception against cyclophosphamide-induced bladder pain and mustard oil-induced nociception in mice [PMID:16450293]
Preuve DObesity
Alpha- and beta-amyrin treatment in mice resulted in lower high-fat diet-induced increases in body weight and visceral fat content [PMID:27525508]. Liposomal leaf extract was also evaluated for effects on obesity in rats [PMID:39056728, 39452080]
Preuve DAcute Pancreatitis
Alpha- and beta-amyrin significantly attenuated cerulein-induced increases in TNF-alpha, interleukin-6, lipase, amylase, MPO, and TBARS in mice [PMID:21400110]
Preuve DHypercholesterolemia/Diabetes
Alpha- and beta-amyrin reduced STZ-induced increases in blood glucose, total cholesterol, and serum triglycerides in mice [PMID:22867128]. Gum resin extract reduced cholesterol production in human hepatocytes [PMID:33800828]
Preuve DGastric Ulcer
Resin significantly attenuated ethanol-induced gastric damage in mice and reduced total acidity in pylorus-ligated rats [PMID:14643690]
Interactions médicamenteuses
Synergistic effects were noted when alpha- and beta-amyrin were associated with gentamicin against S. aureus [PMID:34528866], and when essential oil was combined with amikacin against K. pneumoniae [PMID:37667500].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (mice, rats, fish), with a focus on the pharmacological effects of triterpenes (alpha- and beta-amyrin) and essential oils. No human clinical trials were provided.
Sources PubMed
1.PMID: 30003594 (2019) — Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review. · Fundamental & clinical pharmacology
2.PMID: 28143669 (2017) — Oxidation of monoterpenes in Protium heptaphyllum oleoresins. · Phytochemistry
3.PMID: 39056728 (2024) — Effect of Liposomal Protium heptaphyllum (Alb.) March Extract in the Treatment of Obesity Induced by High-Calorie Diet. · Biology
4.PMID: 39452080 (2024) — Effects of Extended Treatment with Protium heptaphyllum Liposomes on Metabolic Parameters of Obese Rats. · Biology
5.PMID: 30499330 (2020) — Chemical composition of essential oils from different parts of Protium heptaphyllum (Aubl.) Marchand and their in vitro antibacterial activity.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Pretreatment with alpha- and beta-amyrin attenuated acetaminophen-induced increases in serum ALT and AST and replenished hepatic GSH in mice [PMID:15763370]
Preuve DBacterial Infections
Essential oils showed in vitro activity against Prevotella nigrescens, Streptococcus mutans, and Streptococcus mitis [PMID:30499330]. Synergy was observed between the essential oil and amikacin against polymyxin-resistant Klebsiella pneumoniae [PMID:37667500]
· Natural product research
6.PMID: 27041857 (2016) — Essential Oil from the Resin of Protium heptaphyllum: Chemical Composition, Cytotoxicity, Antimicrobial Activity, and Antimutagenicity. · Pharmacognosy magazine
7.PMID: 37667500 (2023) — Synergy between amikacin and Protium heptaphyllum essential oil against polymyxin resistance Klebsiella pneumoniae. · Journal of applied microbiology
8.PMID: 39336133 (2024) — Study of Liposomes Containing Extract from the Leaves of Protium heptaphyllum (Aubl.) March in Animals Submitted to a Mutagenic Model Induced by Cyclophosphamide. · Biology
9.PMID: 11543977 (2001) — Triterpenes from the resin of Protium heptaphyllum. · Fitoterapia
10.PMID: 33800828 (2021) — Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential. · International journal of molecular sciences
11.PMID: 30054835 (2018) — Phytoremediation of Brazilian tree species in soils contaminated by herbicides. · Environmental science and pollution research international
12.PMID: 34770848 (2021) — Biocidal Activity of a Nanoemulsion Containing Essential Oil from Protium heptaphyllum Resin against Aedes aegypti (Diptera: Culicidae). · Molecules (Basel, Switzerland)
13.PMID: 33800018 (2021) — Quali-Quantitative Characterization of Volatile and Non-Volatile Compounds in Protium heptaphyllum (Aubl.) Marchand Resin by GC-MS Validated Method, GC-FID and HPLC-HRMS2. · Molecules (Basel, Switzerland)
14.PMID: 42026118 (2026) — Protium heptaphyllum, a tree native to the Atlantic Forest, is a potential source of compounds against important cocoa phytopathogen. · Scientific reports
15.PMID: 39020065 (2024) — Protium heptaphyllum essential oil from the fruit as a sedative and anesthetic in Rhamdia quelen: influence in cardiac frequency, biochemical, and oxidative parameters. · Fish physiology and biochemistry
16.PMID: 33932517 (2021) — Amazonian medicinal smokes: Chemical analysis of Burseraceae pitch (breu) oleoresin smokes and insights into their use on headache. · Journal of ethnopharmacology
17.PMID: 31780877 (2019) — Chemical Composition and Mechanism of Vibriocidal Action of Essential Oil from Resin of Protium heptaphyllum. · TheScientificWorldJournal
18.PMID: 27525508 (2017) — Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses. · Planta medica
19.PMID: 16450293 (2006) — Attenuation of visceral nociception by alpha- and beta-amyrin, a triterpenoid mixture isolated from the resin of Protium heptaphyllum, in mice. · Planta medica
20.PMID: 21400110 (2011) — Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice. · Inflammation research : official journal of the European Histamine Research Society ... [et al.]
21.PMID: 14643690 (2004) — Gastroprotective and anti-inflammatory effects of resin from Protium heptaphyllum in mice and rats. · Pharmacological research
22.PMID: 15763370 (2005) — Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice. · Journal of ethnopharmacology
23.PMID: 22867128 (2012) — Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice. · Lipids in health and disease
24.PMID: 34528866 (2022) — In silico and in vitro evaluation of efflux pumps inhibition of α,β-amyrin. · Journal of biomolecular structure & dynamics