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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Pseudowintera colorata
Small tree endemic to New Zealand used by Maori for toothache, pain, and skin conditions, containing the antimicrobial compound polygodial.
Pseudowintera colorata (horopito) is a New Zealand endemic tree traditionally used by Māori for pain, infection, and skin conditions. Its primary active compound, polygodial, is a sesquiterpene dialdehyde with antimicrobial, antifungal, and analgesic properties. Evidence is limited (Grade C), primarily from in vitro and pilot studies.
Polygodial exerts its effects by activating TRPA1 and TRPV1 ion channels, leading to calcium influx and subsequent desensitization of nociceptive neurons, which underlies its analgesic action. It also disrupts microbial cell membranes by interacting with ergosterol in fungi and phospholipids in bacteria, causing leakage and cell death. Additionally, polygodial inhibits pro-inflammatory cytokines such as TNF-α and IL-6 via modulation of NF-κB pathway.
Small tree endemic to New Zealand used by Maori for toothache, pain, and skin conditions, containing the antimicrobial compound polygodial.
Pseudowintera colorata (horopito) is a New Zealand endemic tree traditionally used by Māori for pain, infection, and skin conditions. Its primary active compound, polygodial, is a sesquiterpene dialdehyde with antimicrobial, antifungal, and analgesic properties. Evidence is limited (Grade C), primarily from in vitro and pilot studies.
Polygodial exerts its effects by activating TRPA1 and TRPV1 ion channels, leading to calcium influx and subsequent desensitization of nociceptive neurons, which underlies its analgesic action. It also disrupts microbial cell membranes by interacting with ergosterol in fungi and phospholipids in bacteria, causing leakage and cell death. Additionally, polygodial inhibits pro-inflammatory cytokines such as TNF-α and IL-6 via modulation of NF-κB pathway.