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PubMed · Scorpion (Buthus martensii Karsch) in Chinese medicine: a review of traditional uses, chemical constituents, pharmacology, and toxicology. (2025)
PubMed · Anti-epileptic/pro-epileptic effects of sodium channel modulators from Buthus martensii Karsch. (2022)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 28 articles PubMed · modèle : gemma4:31b
Résumé
Quan Xie (Buthus martensii Karsch) is a scorpion species whose venom contains bioactive peptides with potential analgesic, antitumor, and anti-epileptic properties [PMID:30858089, PMID:33178316].
Contexte
Buthus martensii Karsch (BmK) is a scorpion species from China [PMID:24577583, PMID:30858089]. Its venom is a complex mixture of proteins, including neurotoxins and other bioactive peptides [PMID:19931296, PMID:30858089].
Usages traditionnels
In China, Buthus martensii Karsch-analgesic-antitumor peptide (BmK AGAP) has been used to treat cancer, epilepsy, tetanus, tuberculosis, apoplexy, spasm, migraine headaches, and rheumatic pain [PMID:33178316].
Composés actifs
Active components include the analgesic-antitumor peptide (BmK AGAP), a long-chain toxin of 66 amino acids [PMID:33178316], and Martentoxin (MarTX) [PMID:38112732]. Other venom components include Na+, K+, Ca2+, Cl- and TRP channel toxins, enzymes, and protease inhibitors [PMID:31834817].
Injection of Martentoxin (MarTX) into the hippocampal region of mice significantly alleviated convulsive seizures; however, intravenous efficacy required TAT-modification to cross the blood-brain barrier [PMID:38112732]
Preuve CPain and Cancer
The BmK AGAP peptide is reported to have analgesic and antitumor properties [PMID:33178316]
Sécurité et effets indésirables
Scorpion venom can cause severe medical complications, including neurotoxicity, cardiovascular collapse, respiratory dysfunction, and death if injected into the human body [PMID:29999659, PMID:34055554]. Specific complications include myocarditis [PMID:37018229], nephropathy [PMID:25984198], and Takotsubo cardiomyopathy [PMID:38205067].
Grossesse et allaitement
Data on the effects of scorpion stings in pregnant women are very limited [PMID:28613678, PMID:27255088]. No information is available on the clinical use of Centruroides immune f(ab)2 during breastfeeding [PMID:29999659].
Synthèse des preuves
Evidence for the therapeutic use of Buthus martensii Karsch is primarily based on laboratory research (animal models) and literature reviews; there is a lack of high-level human clinical trial data for these specific medicinal applications.
Sources PubMed
1.PMID: 31834817 (2020) — Scorpion venomics: a 2019 overview. · Expert review of proteomics
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— Scorpion envenomation-associated myocarditis: A systematic review.
· PLoS neglected tropical diseases
7.PMID: 25984198 (2011) — Scorpion sting nephropathy. · NDT plus
8.PMID: 19931296 (2010) — Mining on scorpion venom biodiversity. · Toxicon : official journal of the International Society on Toxinology
9.PMID: 33178316 (2020) — The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer. · Evidence-based complementary and alternative medicine : eCAM
10.PMID: 31228480 (2019) — Scorpion envenomation and inflammation: Beyond neurotoxic effects. · Toxicon : official journal of the International Society on Toxinology
12.PMID: 27255088 (2016) — Scorpion Envenomation in Pregnancy. · Southern medical journal
13.PMID: 36567038 (2023) — Ethnomedicines for the treatment of scorpion stings: A perspective study. · Journal of ethnopharmacology
14.PMID: 34055554 (2021) — Neurological and Systemic Manifestations of Severe Scorpion Envenomation. · Cureus
15.PMID: 38205067 (2023) — Takotsubo cardiomyopathy following scorpion envenomation: a literature review. · American journal of cardiovascular disease
16.PMID: 24577583 (2014) — Overview of scorpion species from China and their toxins. · Toxins
17.PMID: 30858089 (2019) — Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch. · Peptides
18.PMID: 25701676 (2015) — Evolution of alternative methodologies of scorpion antivenoms production. · Toxicon : official journal of the International Society on Toxinology
19.PMID: 11273325 (1998) — Scorpion sting. · The Journal of the Association of Physicians of India
20.PMID: 22715546 (2012) — Scorpion sting: update. · The Journal of the Association of Physicians of India
21.PMID: 28509171 (2016) — Nephrotic syndrome after scorpion sting. · CEN case reports
22.PMID: 36641229 (2023) — Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools. · Chinese journal of natural medicines
25.PMID: 16387337 (2006) — Genetic mechanisms of scorpion venom peptide diversification. · Toxicon : official journal of the International Society on Toxinology
26.PMID: 7801339 (1994) — Scorpion envenoming and the role of insulin. · Toxicon : official journal of the International Society on Toxinology
27.PMID: 27397476 (2016) — Scorpion Toxin Polyptides as Therapeutic Agents: An Overview. · Protein and peptide letters