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PubMed · Scorpion (Buthus martensii Karsch) in Chinese medicine: a review of traditional uses, chemical constituents, pharmacology, and toxicology. (2025)
PubMed · Anti-epileptic/pro-epileptic effects of sodium channel modulators from Buthus martensii Karsch. (2022)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Dernière mise à jour : April 2026
Calculer une dose sûre de Quan Xie
Calculateur gratuit de posologie — doses adultes et enfants selon le poids.
How does Quan Xie work to stop tremors and treat epilepsy?
Quan Xie contains neurotoxic compounds, primarily buthotoxin and tityustoxin, which act on sodium channels in nerve cells. These compounds help extinguish internal wind in TCM theory, which manifests as tremors, convulsions, and spasms. The neurotoxins modulate neuronal excitability, potentially reducing seizure activity and involuntary muscle movements. Evidence level C indicates limited clinical trials but some pharmacological support for these mechanisms. Traditional use spans centuries for wind-stroke conditions and epilepsy.
Can Quan Xie interact with blood thinners or anticonvulsant medications?
Quan Xie may interact with anticoagulant and antiplatelet medications due to potential effects on blood coagulation. Combining it with warfarin, aspirin, or other blood thinners could increase bleeding risk. Additionally, because Quan Xie has anticonvulsant properties, it may theoretically enhance or interfere with prescription antiepileptic drugs. Patients taking anticonvulsants should consult a qualified practitioner before adding Quan Xie. Evidence level C; clinical interaction data is limited, so caution is advised.
What is the correct dosage of Quan Xie for adults?
The typical adult dosage of Quan Xie is 2-5 grams of dried whole scorpion daily in decoction form, or 0.6-1 gram when taken as a powder. Dosage varies based on the condition being treated, preparation method, and individual factors. Because Quan Xie contains potent neurotoxins, professional guidance from a qualified TCM practitioner is essential. Self-medication is not recommended. Evidence level C is based on traditional use and limited modern research.
Is Quan Xie safe to take during pregnancy or breastfeeding?
Quan Xie is contraindicated during pregnancy and should be strictly avoided. The neurotoxic compounds, including buthotoxin, may cross the placenta and pose risks to fetal development. Traditional Chinese medicine classifies Quan Xie as unsafe for pregnant women due to its potential to affect the fetus. Breastfeeding women should also avoid this substance. Evidence level C supports this contraindication based on pharmacological properties and traditional knowledge. Always consult a healthcare provider before using any herbal medicine during pregnancy.
What conditions is Quan Xie (Buthus martensii) used to treat?
Quan Xie is traditionally used in Chinese medicine to extinguish wind and stop tremors, making it valuable for epilepsy, stroke recovery, facial paralysis (Bell's palsy), and rheumatic pain. It addresses conditions characterized by internal wind in TCM theory, which includes convulsions, spasms, and involuntary movements. The dried scorpion is also used for chronic pain conditions. Evidence level C indicates traditional use is well-established, but clinical trials are limited. A qualified TCM practitioner should prescribe it based on individual diagnosis.
What are the possible side effects of taking Quan Xie?
Quan Xie can cause allergic reactions in some individuals, particularly those sensitive to scorpion proteins or venom components. Symptoms may include skin rashes, itching, or respiratory distress. People with blood coagulation disorders may experience increased bleeding risk. Other potential side effects include gastrointestinal discomfort. Those with known allergies to scorpions or shellfish should avoid Quan Xie entirely. Evidence level C; adverse effects are documented in traditional sources and case reports. Seek immediate medical attention if severe reactions occur.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 28 articles PubMed · modèle : gemma4:31b
Résumé
Quan Xie (Buthus martensii Karsch) is a scorpion species whose venom contains bioactive peptides with potential analgesic, antitumor, and anti-epileptic properties [PMID:30858089, PMID:33178316].
Contexte
Buthus martensii Karsch (BmK) is a scorpion species from China [PMID:24577583, PMID:30858089]. Its venom is a complex mixture of proteins, including neurotoxins and other bioactive peptides [PMID:19931296, PMID:30858089].
Usages traditionnels
In China, Buthus martensii Karsch-analgesic-antitumor peptide (BmK AGAP) has been used to treat cancer, epilepsy, tetanus, tuberculosis, apoplexy, spasm, migraine headaches, and rheumatic pain [PMID:33178316].
Composés actifs
Active components include the analgesic-antitumor peptide (BmK AGAP), a long-chain toxin of 66 amino acids [PMID:33178316], and Martentoxin (MarTX) [PMID:38112732]. Other venom components include Na+, K+, Ca2+, Cl- and TRP channel toxins, enzymes, and protease inhibitors [PMID:31834817].
Injection of Martentoxin (MarTX) into the hippocampal region of mice significantly alleviated convulsive seizures; however, intravenous efficacy required TAT-modification to cross the blood-brain barrier [PMID:38112732]
Preuve CPain and Cancer
The BmK AGAP peptide is reported to have analgesic and antitumor properties [PMID:33178316]
Sécurité et effets indésirables
Scorpion venom can cause severe medical complications, including neurotoxicity, cardiovascular collapse, respiratory dysfunction, and death if injected into the human body [PMID:29999659, PMID:34055554]. Specific complications include myocarditis [PMID:37018229], nephropathy [PMID:25984198], and Takotsubo cardiomyopathy [PMID:38205067].
Grossesse et allaitement
Data on the effects of scorpion stings in pregnant women are very limited [PMID:28613678, PMID:27255088]. No information is available on the clinical use of Centruroides immune f(ab)2 during breastfeeding [PMID:29999659].
Synthèse des preuves
Evidence for the therapeutic use of Buthus martensii Karsch is primarily based on laboratory research (animal models) and literature reviews; there is a lack of high-level human clinical trial data for these specific medicinal applications.
Sources PubMed
1.PMID: 31834817 (2020) — Scorpion venomics: a 2019 overview. · Expert review of proteomics
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— Scorpion envenomation-associated myocarditis: A systematic review.
· PLoS neglected tropical diseases
7.PMID: 25984198 (2011) — Scorpion sting nephropathy. · NDT plus
8.PMID: 19931296 (2010) — Mining on scorpion venom biodiversity. · Toxicon : official journal of the International Society on Toxinology
9.PMID: 33178316 (2020) — The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer. · Evidence-based complementary and alternative medicine : eCAM
10.PMID: 31228480 (2019) — Scorpion envenomation and inflammation: Beyond neurotoxic effects. · Toxicon : official journal of the International Society on Toxinology
12.PMID: 27255088 (2016) — Scorpion Envenomation in Pregnancy. · Southern medical journal
13.PMID: 36567038 (2023) — Ethnomedicines for the treatment of scorpion stings: A perspective study. · Journal of ethnopharmacology
14.PMID: 34055554 (2021) — Neurological and Systemic Manifestations of Severe Scorpion Envenomation. · Cureus
15.PMID: 38205067 (2023) — Takotsubo cardiomyopathy following scorpion envenomation: a literature review. · American journal of cardiovascular disease
16.PMID: 24577583 (2014) — Overview of scorpion species from China and their toxins. · Toxins
17.PMID: 30858089 (2019) — Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch. · Peptides
18.PMID: 25701676 (2015) — Evolution of alternative methodologies of scorpion antivenoms production. · Toxicon : official journal of the International Society on Toxinology
19.PMID: 11273325 (1998) — Scorpion sting. · The Journal of the Association of Physicians of India
20.PMID: 22715546 (2012) — Scorpion sting: update. · The Journal of the Association of Physicians of India
21.PMID: 28509171 (2016) — Nephrotic syndrome after scorpion sting. · CEN case reports
22.PMID: 36641229 (2023) — Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools. · Chinese journal of natural medicines
25.PMID: 16387337 (2006) — Genetic mechanisms of scorpion venom peptide diversification. · Toxicon : official journal of the International Society on Toxinology
26.PMID: 7801339 (1994) — Scorpion envenoming and the role of insulin. · Toxicon : official journal of the International Society on Toxinology
27.PMID: 27397476 (2016) — Scorpion Toxin Polyptides as Therapeutic Agents: An Overview. · Protein and peptide letters