Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Rhamnus purshiana
Native American sacred bark used as laxative; bark must be aged one year before use due to harsh fresh compounds.
Rhamnus purshiana (cascara sagrada) is a traditional Native American laxative derived from the bark of the buckthorn tree, primarily used as a stimulant laxative for constipation and bowel preparation. Its key active compounds are anthraquinone glycosides, including cascarosides A and B, which are converted by gut microbiota into active aglycones such as emodin and aloe-emodin. The bark must be aged for at least one year to reduce harsh purgative effects and improve tolerability.
Cascara's anthraquinone glycosides are hydrolyzed by colonic bacteria to active aglycones (e.g., emodin, aloe-emodin), which inhibit Na+/K+-ATPase in enterocytes, reducing electrolyte absorption and increasing water secretion into the lumen. This stimulates colonic peristalsis via prostaglandin E2 and nitric oxide pathways, leading to laxation within 6–12 hours. Additionally, aglycones may activate the enteric nervous system and promote colonic motility through interaction with serotonin receptors.
Native American sacred bark used as laxative; bark must be aged one year before use due to harsh fresh compounds.
Rhamnus purshiana (cascara sagrada) is a traditional Native American laxative derived from the bark of the buckthorn tree, primarily used as a stimulant laxative for constipation and bowel preparation. Its key active compounds are anthraquinone glycosides, including cascarosides A and B, which are converted by gut microbiota into active aglycones such as emodin and aloe-emodin. The bark must be aged for at least one year to reduce harsh purgative effects and improve tolerability.
Cascara's anthraquinone glycosides are hydrolyzed by colonic bacteria to active aglycones (e.g., emodin, aloe-emodin), which inhibit Na+/K+-ATPase in enterocytes, reducing electrolyte absorption and increasing water secretion into the lumen. This stimulates colonic peristalsis via prostaglandin E2 and nitric oxide pathways, leading to laxation within 6–12 hours. Additionally, aglycones may activate the enteric nervous system and promote colonic motility through interaction with serotonin receptors.