Robinia pseudoacacia (Robinia pseudoacacia): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Robinia pseudoacacia work as a digestive remedy?

Robinia pseudoacacia flowers contain flavonoids, tannins, and essential oils that provide anti-inflammatory and mild astringent effects on the digestive tract. These compounds may help soothe gastrointestinal irritation and support healthy digestion. The flowers have traditional carminative properties, meaning they may help relieve gas and bloating. Evidence level: C (traditional use with pharmacological plausibility).

Does Robinia pseudoacacia interact with any medications?

There are no well-documented drug interactions for Robinia pseudoacacia flowers in the scientific literature. However, research is limited, and the bark, seeds, and roots contain toxic compounds that should never be consumed. Individuals taking prescription medications should consult a healthcare provider before using any herbal preparation. Evidence level: C.

What is the recommended dosage for Robinia pseudoacacia flowers?

The traditional adult dosage for Robinia pseudoacacia flowers is 3-5 grams taken twice daily, prepared as a tea or consumed as food. The flowers can be eaten fresh or dried. This dosage is based on folk medicine tradition rather than clinical trials. Only the flowers should be used medicinally. Evidence level: C.

Is Robinia pseudoacacia safe during pregnancy and breastfeeding?

Robinia pseudoacacia flowers are considered safe for consumption during pregnancy when eaten in normal food amounts, with no adverse effects reported in traditional use. However, the bark, seeds, and roots contain robin, a toxic toxalbumin, and must be strictly avoided during pregnancy. Pregnant individuals should use only the flowers and consult a qualified healthcare provider before use. Evidence level: C.

Which parts of the black locust tree are poisonous?

The bark, seeds, and roots of Robinia pseudoacacia contain robin, a toxic toxalbumin that can cause severe gastrointestinal symptoms including nausea, vomiting, diarrhea, and potentially life-threatening toxicity. Only the flowers are considered safe for consumption. The leaves may also contain toxic compounds. Internal use of any part other than the flowers is strongly discouraged. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Robinia pseudoacacia (Black Locust) is a fast-growing tree with documented antioxidant and antibacterial properties [PMID:39134988], though it can cause hypersensitivity and toxicity [PMID:16680930, PMID:39810820].

Contexte

Robinia pseudoacacia, also known as black locust, is a non-native, invasive tree species from North America that has become common in Europe and Asia [PMID:33336522, PMID:26634550]. It is characterized by its high economic value, nitrogen-fixing root nodules, and specialized stipular spines [PMID:37765417, PMID:42169710].

Composés actifs

Identified compounds include flavonoids such as acacetin, secundiflorol I, mucronulatol, isomucronulatol, and isovestitol [PMID:21214467], as well as robinetin, myricetin, and quercetin [PMID:16132219]. Additionally, antioxidant caffeate esters of fatty alcohols (R1-R9) have been detected in the stem bark [PMID:39683834].

Mécanisme d'action

Flower exosome-like nanoparticles (RFELNs) may attenuate mucosal ferroptosis by inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation [PMID:39134988]. A complex of Robinia pseudoacacia flower extract and Ganoderma lucidum (NEPROBIN) has been shown to suppress LPS-induced activation of MAPK and NF-κB signaling pathways and reduce transcriptional activity of NF-κB [PMID:40298637].

Preuves cliniques

Preuve DGastrointestinal mucosal injury (hypoxia-induced)

Oral administration of flower exosome-like nanoparticles significantly ameliorated gastric and small intestinal mucosal injury in mice [PMID:39134988]

Preuve DKidney inflammation and fibrosis

A complex of Ganoderma lucidum and Robinia pseudoacacia flower extract (NEPROBIN) alleviated H2O2-induced oxidative stress in vitro and reduced kidney damage in mice [PMID:40298637]

Preuve DProstate cancer (PC-3 cell line)

The flavonoid acacetin demonstrated significant cytotoxicity against the PC-3 prostate cell line [PMID:21214467]

Sécurité et effets indésirables

Pollen from R. pseudoacacia can cause hypersensitivity, with 43% of patients with pollinosis showing positive skin prick test reactions [PMID:16680930]. In veterinary cases, ingestion of bark led to severe poisoning in horses, manifesting as weakness, fever, hyperammonaemia, encephalopathy, and death [PMID:39810820].

Synthèse des preuves

The current evidence is primarily based on in vitro studies, animal models (mice, horses), and botanical/ecological research; there are no human clinical trials provided.

Sources PubMed

1.PMID: 39134988 (2024) — Oral administration of Robinia pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis caused by hypoxia through inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation. · Journal of nanobiotechnology
2.PMID: 33336522 (2021) — Black locust (Robinia pseudoacacia L.) range contraction and expansion in Europe under changing climate. · Global change biology
3.PMID: 16680930 (2006) — Hypersensitivity to black locust (Robinia pseudoacacia) pollen: "allergy mirages". · Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
4.PMID: 37765417 (2023) — Diverse Interactions: Root-Nodule Formation and Herb-Layer Composition in Black Locust (Robinia pseudoacacia) Stands. · Plants (Basel, Switzerland)
5.PMID: 26634550

Robinia pseudoacacia

Sources et citations

Calculer une dose sûre de Robinia pseudoacacia

Salvia nemorosa

Opopanax chironium

Mountain Pepper

Questions fréquentes

Résumé

Contexte

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Robinia pseudoacacia

Sources et citations

Calculer une dose sûre de Robinia pseudoacacia

Plantes associées

Salvia nemorosa

Opopanax chironium

Mountain Pepper

Questions fréquentes

Résumé

Contexte

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales