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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Catharanthus roseus
In folk medicine context (distinct from pharmaceutical extraction), the leaves are used in South Asian, Caribbean, and African traditions for diabetes and hypertension at culinary doses.
Rosy periwinkle (Catharanthus roseus) leaf is used in South Asian, Caribbean, and African folk medicine primarily for diabetes and hypertension, but its alkaloid content (e.g., vincamine, ajmalicine) poses significant toxicity risks. Despite traditional use, clinical evidence is limited (Grade C), and the herb is not recommended for self-medication due to potential neurotoxicity and drug interactions. Key active compounds include loganin, secologanin, and various indole alkaloids that influence glucose metabolism and vascular tone.
The hypoglycemic effect is attributed to indole alkaloids such as vindoline and catharanthine, which may enhance insulin secretion and improve peripheral glucose uptake via AMPK activation. Hypotensive actions involve ajmalicine and serpentine, which act as alpha-1 adrenergic receptor antagonists and inhibit angiotensin-converting enzyme (ACE). Anti-inflammatory properties are linked to inhibition of COX-2 and NF-κB pathways by phenolic compounds. However, these mechanisms are derived from in vitro and animal studies; human data are scarce and inconsistent.
In folk medicine context (distinct from pharmaceutical extraction), the leaves are used in South Asian, Caribbean, and African traditions for diabetes and hypertension at culinary doses.
Rosy periwinkle (Catharanthus roseus) leaf is used in South Asian, Caribbean, and African folk medicine primarily for diabetes and hypertension, but its alkaloid content (e.g., vincamine, ajmalicine) poses significant toxicity risks. Despite traditional use, clinical evidence is limited (Grade C), and the herb is not recommended for self-medication due to potential neurotoxicity and drug interactions. Key active compounds include loganin, secologanin, and various indole alkaloids that influence glucose metabolism and vascular tone.
The hypoglycemic effect is attributed to indole alkaloids such as vindoline and catharanthine, which may enhance insulin secretion and improve peripheral glucose uptake via AMPK activation. Hypotensive actions involve ajmalicine and serpentine, which act as alpha-1 adrenergic receptor antagonists and inhibit angiotensin-converting enzyme (ACE). Anti-inflammatory properties are linked to inhibition of COX-2 and NF-κB pathways by phenolic compounds. However, these mechanisms are derived from in vitro and animal studies; human data are scarce and inconsistent.